Doernbecher Children's Hospital scientist earns coveted Javits award
...his appears related to a molecule calledhyaluronic acid (HA) that builds up in the damaged white matter andprevents the normal production of myelin. "The oligo-cells are blocked at a critical period in their celldevelopment before they are able to make myelin. The fact that thesecells appear normal and ...JCI table of contents: Aug. 9, 2007
...ing feeding behavior in mice. TITLE: Brain fatty acid synthase activates PPAR-alpha to maintain energy homeostasis AUTHOR CONTACT: Clay F. Semenkovich Washington University School of Medicine, St. Louis, Missouri, USA. Phone: (314)-362-4454; Fax: (314)-362-7641; E-mail: csemenko@wustl.edu . View the...Sugar and spice and everything nice: Health differences in newborn girls and boys
...tudy has determined that the rapid accumulation of acid in newborn female livers may shed light on why pediatric liver transplants are less successful when the livers are donated from infant girls. The studies were conducted by Danny Quaglietta, Department of Physiology, Michael P. Belanger, Departmen...Other highlights in the Aug. 7 JNCI
... retinol and zinc; riboflavin and niacin; ascorbic acid and molybdenum; beta-carotene, alpha-tocopherol, and selenium; or placebo pills. After 5.25 years, none of the vitamin-mineral combinations caused a statistically significant reduction in liver cancer deaths overall. However, some combinations red...Taking a supplement of glycine helps prevent degenerative diseases such as arthrosis or osteoporosis
...>Spanish . Glycine is a non-essential amino acid used by the organism to synthesise proteins and is...lycine, since supplementing a diet with this amino acid leads to a notable improvement in symptomology without the need to take pain-killers. A very comm...ASU researchers partner with UOP to make biofuel for military jets a reality
... similar to other vegetable oils in terms of fatty acid composition, the oil yield of algae is projected to be at least 100 times that of soybean per acre of land on an annual basis. ASU, UOP LLC, Honeywell Aerospace, Southwest Research Institute and Sandia National Laboratories researchers will be wor...New strategy for treating allergic disorders
...ntake of allergens or auto-antigens via the lactic acid bacterium Lactococcus lactis might be a new strate...llergens can be administered orally via the lactic acid bacterium. Based on this principle, which has been patented by VIB, ActoGeniX − a spin-off fro...A low expression of MX2 gene exists in the white blood cells of narcoleptics
...nducted the study from a pool of total ribonucleic acid (RNA) a nucleic acid polymer that plays several important roles in the processes that translate genetic information from ...Altering a protein makes mice less fearful
...loss or chemical inhibition of a protein, known as acid sensing ion channel protein (ASIC1a), reduces innate fear behavior in lab animals, making normally timid mice relatively fearless. The findings might provide useful insight into anxiety disorders and may even point the way to a new therapeutic target...Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
...ch consists of the agents: 5-fluorouracil, folinic acid and oxaliplatin. Through the course of the study, the researchers monitored the patients for an immune response to 5T4. Eleven of the 17 patients who received the complete course of vaccinations (six injections) mounted strong immune responses to ...Chickens dieting to help Delaware waterways
...wo-thirds of the phosphorus in this food is phytic acid or phytate, which is a form of phosphorus that poultry and pigs can't digest, so it goes right through them, he noted. Phytase is an enzyme that is added to poultry feed at the mill that helps broilers and other poultry utilize more indigestible ph...Negative effects of plastic's additive blocked by nutrient supplements
...esearchers discovered that administration of folic acid or genistein, an active ingredient in soy, during ...antly, when pregnant mothers were also given folic acid or genistein, the epigenetic influence of BPA was counteracted, she added. BPA is a synthetic estr...Research shows NPD1 protects a key component of vision
... is DHA (docosahexaenoic acid), an essential fatty acid (must be provided by the diet) of the omega-3 fatty acid family enriched in RPE cells in the retina and brain. DHA is a target of oxidative stress in patholo...Call for EU to launch major project to map out all our proteins
...to separate out the individual proteins. The amino acid sequence of each protein can be determined after separation, from the relationship between electric charge and mass. As Aebersold noted, the biggest prize of proteomics will be a much simpler and efficient technique for identifying individual protein......dimensionally cross-linked polymer containing many acid groups. This polymer network is so heavily soaked in liquid that it forms a solid, gelatinous mass. The second surface is a silicon chip onto which a polybase has been deposited. This polybase consists of polymer chains that stretch brush-like from t...Enzyme discovery sheds light on vitamin D
...the discovery reveals that changing a single amino acid in the hydroxylase enzyme will cause it to take a ...ngly, they discovered that altering a single amino acid completely changes the enzyme from a human pattern to an opossum pattern. This change can be flicked...Eat fish -- especially if you drink high levels of alcohol
...two types, Brenna noted: the omega-6 PUFA linoleic acid (LA), also called n-6 fats, and the omega-3 PUFA linolenic acid (ALA), also called n-3 fats. "Most Americans consume adequate amounts of LA in their diets through ...Coming soon -- Protein synthesis without amino acids?
...y formed by the linking of an amino group with the acid group of individual amino acids. Like pearls on a string, the amino acids then line up. However, to get to such a structure, it isnt absolutely necessary to start from amino acids. Imines, compounds with a carbon-nitrogen double bond, could be an ide...Scientists a step closer to understanding how anaesthetics work in the brain
... The new research has identified a specific amino acid in the potassium channel which, when mutated, bloc...used to identify the location of the precise amino acid to which the anaesthetic binds on the potassium channel, giving the team a clearer picture than ever...Protein pulling -- Learning how proteins fold by pulling them apart
...ar chains, like strands of pearls, with each amino acid representing a bead on the strand. However, knowin...ape, scientists hope to learn more about how amino acid sequences affect protein function and how folding goes awry, as with some diseases. At the halfway...