Tag: "activate" at biology news

Beyond batteries: Storing power in a sheet of paper

...es in human sweat, blood, and urine can be used to activate the battery device. Its a way to power a small device such as a pacemaker without introducing any harsh chemicals such as the kind that are typically found in batteries into the body, Pushparaj said. The materials required to create the paper ...

Abnormal fat metabolism underlies heart problems in diabetic patients

...xcess lipids. But as these lipids enter cells they activate lipid-digesting enzymes. In previous studies, Gross and colleagues identified a particular lipid-digesting enzyme that becomes more active in diabetic heart muscle and contributes to the breakdown of cardiolipin. Recently, Gross and his colleague Da...

Weizmann Institute scientists discover a control mechanism for metastasis

...r, which, in addition to controlling movement, can activate a number of processes in the cell including division and differentiation. The growth factor attaches to a receptor on the cell wall, initiating a sequence of changes in the cellular structure. The cells internal skeleton an assembly of densely-packe...

Discovery of new protein could provide new understanding of male fertility

...T10. Surprisingly, the enzyme they found could not activate FAT10 but instead activated ubiquitin itself. The researchers then tested whether this enzyme, which they called UBE1L2, also helped degrade proteins by working with E2 and E3 enzymes. They confirmed that this was indeed the case. Groettrup and his...

Identified mechanism in the malaria parasite to help it adapt to infected individuals

..., the scientists have found that P. falciparum can activate and deactivate the expression of 7 of these genes (and their corresponding proteins) without compromising the parasites ability to enter normal or modified red blood cells. According to Corts, this suggests that the varied expression of these genes m...

News tips from ACS Chemical Biology

... How the sex hormones estrogen and testosterone activate cell signaling pathways Helper peptides that can influence the opening of calcium channels in cell membranes A new technique called the double barrel shotgun approach that helps pinpoint key cellular proteins How tricking cells w...

Marijuana component opens the door for virus that causes Kaposi's sarcoma

...at by bonding to these receptors, low doses of THC activate two proteins responsible for maintaining a cells internal framework, or cytoskeleton. By altering the cytoskeleton, THC effectively opens the door for KSHV, allowing the virus to more easily enter and infect the cell. We can take away that effect by ...

Discovery in plant virus may help prevent HIV and similar viruses

...ne in the protein complex that retroviruses use to activate transcription. These organisms die if that gene is completely blocked because of its essential role during transcription. This makes it difficult to analyze the function the gene may have in the organisms' growth, development and survival. Unlike tho...

MIT model could predict cells' response to drugs

...es of signals in which proteins, known as kinases, activate other cell machinery to achieve a specific result, e.g., expression of certain genes, or actions of cytoskeletal proteins. While the same stimuli can produce diverse responses in different types of cells, the researchers believe they can use the same...

JCI table of contents -- July 26, 2007

... sensing increases in cholesterol, these receptors activate signaling pathways that remove diet-derived choles...rugs. However, the effects of synthetic drugs that activate these two receptors have not been well studied. In a study appearing online on July 26 in advance of...

Boston Univeristy bioengineers devise 'dimmer swith' to regulate gene expression in mammal cells

...hat can be used to turn on, shut off, or partially activate a genes function. Professor James Collins, Professor Charles Cantor and doctoral candidate Tara Deans invented the switch, which can be tuned to produce large or small quantities of protein, or none at all. The research detailing their new switch...

Scientists find stem cell switch

... ethylene provides signals from the environment to activate cell division when the conditions are right. The research was carried out in the mustard-like plant Arabidopsis, but it is thought to apply to other plant species....

UCLA study links air pollution to clogged arteries

...articles and oxidized fats had worked in tandem to activate the genes that promote cellular inflammation a major risk factor for atherosclerosis, said Dr. Jesus Araujo, UCLA assistant professor of medicine and director of environmental cardiology at the Geffen School of Medicine. The interaction left a ge...

Study identifies new gene therapy tools for inherited blindness

...wly discovered elements can be used as switches to activate blindness therapies. "This result is significant because the number of cis-regulatory elements previously available for gene therapy was quite limited," Corbo explains. By some estimates, photoreceptors are the most energy-intensive cells in the hu...

'Preconditioning' helps protect brain's blood vessels from stroke

...s -- such as the ischemia that occurs in stroke -- activate certain enzymes that produce NO. This process also produces destructive, oxidative byproducts called free radicals. According to the new study, NO combines with these free radicals to produce low levels of another molecule, called peroxynitrite. ...

JCI table of contents: July 19, 2007

...al expression of this mutated protein was found to activate the ERK1/2 pathway and further studies confirmed that activation by mutant SHP2 was necessary and sufficient to cause the heart abnormalities. The authors went on to show that prevention of ERK1/2 activation was able to prevent the development of car...

One man's junk may be a genomic treasure

...ulatory signals and other information necessary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence are bracketed by punctuation marks. The researchers data suggest that repeated genomic sequences might be a...

JCI table of contents: July 12, 2007

...the protein Src, which cooperates with estrogen to activate ER-alpha breakdown via proteolysis. In line with this finding, Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis. The data raise the possibility that for at least a subset of ER-alphanegative breast cancers, Src may stimulat...

Tracing Parkinson's lethal mechanism

.... They also found evidence that calpains, in turn, activate a cellular switch called Cdk5. The question, however, was how this abnormal activation ultimately kills neurons. In their new studies, the researchers analyzed neurons to determine that Cdk5 regulates yet another enzyme called Prx2. This enzyme is ...

Cell receptor may lead to new 'biomarker' for pancreatic cancer

...e kinases are proteins on the cell surface used to activate specific body functions -- for example cell growth...he protein HGFL (hepatocyte growth factor-like) to activate the RON receptor. Although stimulating the RON receptor had no effect on pancreatic cell growth, blo...

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