Notorious cancer gene may work by destroying messenger
...oduction of proteins such as growth factors, which activate genes in response to a hormone or other signal. PMR1 also plays a key role in Cooley's anemia, which causes the loss of red blood cells in infants and children. For the present study, Schoenberg and coauthor Yong Peng, a research associate in S...Study: Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
...diac arrest is on the willingness of bystanders to activate emergency medical services and promptly initiate continuous chest compressions in a case of witnessed unexpected collapse in an adult," Ewy says. "It is also very interesting to find how a sizeable group of laypeople, by spontaneously performing a ...Researchers identify molecular basis of inflammatory bowel disease
...el that does not express NEMO, a protein needed to activate NF-kB, in intestinal epithelial cells. As a result, these mice developed severe chronic intestinal inflammation very similar to Colitis in humans. "A close look at the mice revealed that their gut epithelium was damaged," says Manolis Pasparakis, who...Progress toward artificial photosynthesis?
... re-formsan ideal catalyst. It can even be used to activate carbon dioxide. It was thus possible to oxidize benzene (an aromatic six-membered carbon ring) to phenol (which has an additional OH group). The by-product of the reaction is carbon monoxide (CO), which can be used directly for chemical syntheses. F...Light-activated compound silences nerves, may one day help epileptics
...light in the dysfunctional region. The light would activate the drug only when seizure-like firing patterns started to appear. Scientists in the laboratory of Douglas F. Covey, Ph.D., professor of molecular biology and pharmacology, created the drug by linking a steroid known to have anesthetic effects with ...Researchers find the mechanism by which cells resist chemotherapy
...By blocking the replication process, the mutations activate a type of enzyme, the ATR kinase, which phosphorylates (introduces phosphate groups into) histone H2AX, a protein present in the chromatin that surrounds the damaged DNA. The phosphorylated histone H2AX indicates the location of the genetic damage to...Researchers wake up viruses inside tumors to image and then destroy cancers
PHILADELPHIA -- Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to id...mbinder, M.D., Ph.D., have been working on ways to activate the reproductive, or "lytic" cycle, within the virus to make it replicate within the tumor cell. Whe...Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
...h a signal telling it to divide, it also begins to activate a "braking system" that eventually stops cell division and returns the cell to a resting state. When that braking system is faulty, uncontrolled cell division and the growth of cancer can result. Weizmann Institute scientists studied this system of ...A chemotherapy drug packs a one-two punch
...p90 on the surface of dying cells, and so couldn't activate dendritic cells to the degree that bortezomib did. And their findings aren't limited to a single cancer: After treatment with bortezomib, dying lymphoma and breast cancer cells experienced the same increase in hsp90. How well this research will t...HIV protein enlisted to help kill cancer cells
...ls to die." Hawkins says he thinks treatments that activate apoptosis mechanisms could provide new options for patients with the deadliest cancers such as pancreatic cancer which have very low rates of survival. He says he believes that clinical trials of these compounds could be just a few years away. Hawk......ersion of the BRaf gene that the researchers could activate at will both temporally and spatially. After activating BRaf specifically in the lungs of mice at 6-8 weeks of age, the researchers observed that the BRaf-mutant mice (or BRaf(VE), as they are known) developed multiple lung tumors that were patholog...Columbia scientists determine 3-dimensional structure of cell's 'fuel gauge'
... explained that researchers do not yet know how to activate AMPK without activating other proteins and causing potentially toxic side effects. However, he notes that this development in understanding the atomic resolution structure of the protein provides researchers a powerful new tool for the design of use...New role in asthma for old drug
...t, it prevented the immune cells in the lungs that activate the Th2 cell response (known as dendritic cells [D...ving the lungs and going to the site at which they activate the allergic Th2 cell response. Second, it blocked the DCs becoming activated enough to stimulate an...JCI table of contents: Feb. 1, 2007
...t, it prevented the immune cells in the lungs that activate the Th2 cell response (known as dendritic cells [D...ving the lungs and going to the site at which they activate the allergic Th2 cell response. Second, it blocked the DCs becoming activated enough to stimulate an...Central and peripheral signals set the circadian liver clock
...ng sites for the transcription factors (HSFs) that activate heat-shock proteins, future experiments will probe...cluding elevated temperature and oxidative stress, activate HSF1. Its possible that HSF1, by sensing rhythmic changes in metabolism, synchronizes peripheral clo...Novel laboratory technique nudges genes into activity
... suppressors, and using this method to selectively activate those genes might help the body fend off cancer, Dr. Janowski said. Genes are segments of DNA housed in chromosomes in the nucleus of every cell and they carry instructions for making proteins. Faulty or mutated genes lead to malfunctioning, missi...Scripps Research study reveals new function of protein kinase pathway in tumor suppression
...erapy--for future drug development to artificially activate this pathway in cancer cells." The human body has several built-in mechanisms that prevent cancer development. One is cell death, or apoptosis. Another is premature senescence, a recently identified tumor-restricting response that permanently stops......the G protein targeted so quickly and precisely to activate the channel? Reuveny and his team found that the receptor and G protein are physically bound together in a complex, allowing the process to be finely tuned. When the receptor receives a chemical message from the neurotransmitter, it is already hoo...Scripps Research study reveals new activation mechanism for pain sensing channel
...e many noxious and pungent compounds were known to activate this pain receptor, we discovered that they do so ...ons. In fact, any cysteine reactive agent seems to activate TRPA1, although we don't know exactly how cysteine binding translates into ion channel activation." ......ulate the production of the ligands which bind and activate EGFR," Kenny said. "We reasoned that this binding... ligands, called Amphiregulin and TGF-alpha, which activate EGFR. Bissell and Kenny found that by targeting TACE (also known as ADAM17) with either molecular ...