Scientists find brown fat master switch
...in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating. A team headed by Bruce Spiegelman, PhD, suggests in the July issue of Cell Metabolism that turning up the equivalent switch in people might be a new strategy for treating overwei...Insulin sensitizer also serves as energy-conserving signal to the brain
...ty and obesity-linked diseases, he added. White adipose tissue (WAT) is a major site of energy storage and plays an important role in energy balance, the researchers said. It is also recognized as an important endocrine organ that secretes a number of biologically active signaling proteins, called adipoki...New blood test might offer early warning of deep belly fat
...P4 may provide a mechanistic link between visceral adipose tissue accumulation and the increased metabolic and cardiovascular risks associated with it. Kahn said her group is still investigating whether the effects of RBP4 depend on vitamin A or whether they are due to RBP4 protein itself....Researchers use adult stem cells to create soft tissue
...lls harvested from the patients own bone marrow or adipose tissue. Mesenchymal stem cells can differentiate into bone, fat, cartilage and other types of cells. Our research has shown that mesenchymal stem cells can create tissue that is biocompatible with the host and that the continuous generation of thes...University of Pittsburgh researchers culture blood-forming stem cells from human fat tissue
...ious reports that the stromal vascular fraction of adipose tissue contains stem cells that give rise to peric... isolated the stromal vascular fraction from human adipose tissue and expanded these cells by growing them in a specialized blood-culturing medium for 21 to 42...New techniques redefine assessment of liver disease
...dy, researchers examined connections between white adipose tissue (WAT, white fat) in the abdomen and medical disorders including insulin resistance (IR, inadequate response to insulin) and diabetes mellitus (DM, a metabolic disorder characterized by high blood sugar) in patients with obesity and NAFLD to ev...How does soy promote weight loss? University of Illinois scientist finds another clue
...a similar way. Leptin is a hormone produced in our adipose tissue that interacts with receptors in the brain and signals us that were full so we stop eating," said Elvira de Mejia, a U of I assistant professor of food science and human nutrition. The researchers wanted to see if soy protein hydrolysates co...'Exercise pill' switches on gene that tells cells to burn fat
... had in being able to turn on the PPAR-d switch in adipose or fat cells, activating local metabolism and increasing the amount of calories burned. As a Howard Hughes Medical Investigator at The Salk Institute's Gene Expression Laboratory, Dr. Evans discovered the role of the gene for PPAR-d, the master regul...Hot flashes -- Studies explore the role of genes, obesity and alcohol
...rised by the findings related to estrogen, because adipose tissue produces and stores estradiol, the major estrogen in humans. Most people had assumed that obese women would have higher circulating estrogen levels because of this, Flaws said. That assumption turned out to be incorrect, at least for women in ...Leanest teens are biggest energy users and consumers
...xams on 434 study participants to measure visceral adipose tissue. Visceral adiposity, found in and around organs in the abdominal cavity, is closely linked to general obesity but is considered the worst fat because it is more metabolically active, ramping up pro-inflammatory markers and dramatically increas...UCLA identifies new molecule involved in the body's processing of dietary fat
...and heart tissues that are hungry for fuel or to adipose tissue for energy storage. Molecules called prote... on the endothelial cells of capillaries of heart, adipose tissue and skeletal muscle. Interestingly, scientists found that this protein was absent from the...Newly discovered 'platform' for processing dietary fat
...nding protein is found at high levels in heart and adipose tissue, the same tissues that express high levels of the enzyme that breaks chylomicrons down, they report. The researchers conclude that GPIHBP1 is crucial for chylomicron processing. It is located on the inner surface of the capillary and binds b...Joslin study reveals how a specific fat type can protect against weight gain and diabetes
...nergy for future needs, whereas brown fat or brown adipose tissue (BAT) burns energy and generates heat. White fat, which is packed with large lipid droplets, is deposited under the skin, around internal organs and as visceral fat one of the most harmful forms of abdominal fat. Brown fat, on the other ha...Magic beans -- Anti-obesity soya could help prevent diabetes
...aving an effect on fat metabolism in the liver and adipose tissue, reducing synthesis of new fatty acids and ...lin action, mainly as a result of excess abdominal adipose tissue - so loss of weight often improves glycaemic control, says Dr Bender. Lynne Garton, a regis...JCI table of contents -- February 22, 2006
...e expression of PKC-epsilon in the liver and white adipose tissue of rats did not decrease fat accumulation f...g low levels of PKC-epsilon in the liver and white adipose tissue. This identification of PKC-epsilon as a mediator of hepatic steatosisinduced hepatic insulin...Researchers discover master metabolism regulator with profound effect on fat metabolism
... percent of their liver mass and 97 percent of the adipose or fatty tissue from their abdomens. This respons... steady liver mass and lost only 69 percent of the adipose tissue on their abdomens. One of the especially encouraging aspects of the research by Guo and Cav...New player in commitment to life as a fat cell
...tion since it is both necessary and sufficient for adipose differentiation both in vitro and in vivo, the res... exhibited increased XOR activity and urate in the adipose tissue. Urate is a salt derived from uric acid. "Our results identify XOR as a potential therapeut...Major link in brain-obesity puzzle found
... tissues of the body, including fat cells known as adipose tissue, as well as the liver, heart, pancreas and muscle. Rui and his team also explored the role of SH2B1 in fat cells, finding that the knockout mice that lacked the SH2B1 gene stored away much more fat than normal mice, and had much larger fat ...JCI table of contents: January 2, 2007
...T TITLE: Obesity induces a phenotypic switch in adipose tissue macrophage polarization AUTHOR CONTACT: Alan Saltiel University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 615-9787; Fax: (734) 763-6492; E-mail: saltiel@lsi.umich.edu . View the PDF of this article at: https://www.the-jci.org/a......enditure by altering the functions of cells in the adipose tissue (fat tissue) and brain. This study increases our understanding of the function of these two hormones and might influence the development of drugs designed to target these hormones for the treatment of type 2 diabetes. TITLE: Extrapancreatic i...