Tag: "adjuvant" at biology news

JCI table of contents, December 15 2004

...ncer and infectious diseases. TITLE: Utilizing the adjuvant properties of Cd1d-dependent NK T cells in T cellmediated immunotherapy AUTHOR CONTACT: Vincenzo Cerundolo Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. Phone: 44-1865-222412; Fax: 4...

FDA approves ABRAXANE(TM) for metastatic breast cancer

...r metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included ...ior chemotherapy; 27% received chemotherapy in the adjuvant setting; 40% in the metastatic setting, and 19% in both metastatic and adjuvant settings. Of the pa...

Readers of genome decipher signatures of cancer patient outcomes

...of skin cancer. "In cutaneous melanomas, no active adjuvant therapy has been fully demonstrated so far," Spatz said. "The identification of new potential therapeutic targets is crucial and overcomes the importance of prognostication methods. "Some of the genes in our signature belong to the same cellular pat...

Romond heads up study and reduces breast cancer recurrence

...fit of combining trastuzumab with chemotherapy for adjuvant treatment of women with HER-2 positive breast cancer," said Romond. The clinical trials were sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and conducted by a network of researchers led by NSABP and the ...

Wake Forest scientists find new combination vaccine effective against plague

...ve also established that flagellin is an effective adjuvant in monkeys immunized with flagellin and a Yersina ...g foundation for the future use of flagellin as an adjuvant in humans," Mizel said. He said the research shows that the mice were protected for at least three ...

Anti-fungal drug may help treat cancer

...d along with more powerful anticancer agents as an adjuvant in cancer chemotherapy." The authors found that the drug inhibits the proliferation of cancer cells by affecting mitosis, or cell division, and mitotic spindle microtubule function. They conclude: "A mild suppression of microtubule dynamics by gris...

JCI table of contents August 1, 2005

...nd show that it ameliorates the autoimmune disease adjuvant arthritis in rats. This study not only adds to our understanding of the mechanisms of HIV pathogenesis, but it also shows that the FP molecule, independent of HIV, may provide a novel way to decrease undesirable immune responses. Title: HIV-1 Fusion ...

HIV domains take on new functions in mediating immunity

...nd show that it ameliorates the autoimmune disease adjuvant arthritis in rats. This study not only adds to our understanding of the mechanisms of HIV pathogenesis, but it also shows that the FP molecule, independent of HIV, may provide a novel way to decrease undesirable immune responses....

Effective Alzheimer treatment: The nose knows

...latiramer acetate) plus a recently developed nasal adjuvant that has been shown to be safe in humans and activates microglia, cells which then clear beta-amyloid in the brain without evidence of toxic effects. The findings have both basic and clinically relevant implications. The discovery of a non-antibody...

JCI table of contents September 1, 2005

...latiramer acetate) plus a recently developed nasal adjuvant that has been shown to be safe in humans and activ... Title: Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer's disease. AUTHOR CONTACT...

Other highlights in the August 17 JNCI

...l oncologists, but they do not receive recommended adjuvant treatment at the same rates after this consultation, according to a new study. Studies have shown that black patients are less likely than white patients to receive screening and diagnostic tests and some treatments. A 2001 study, published in the Jo...

Microarray technology for tailoring breast cancer therapy

...edict a patient's response in the five years after adjuvant therapy for breast cancer. Identifying patients wh...d to predict which patients would not benefit from adjuvant therapy, and avoid patients being given therapies with the potential of causing more harm than good....

New monoclonal antibody therapies offer significant survival advantage for breast cancer patients

...FS) in HER-2 positive breast cancer patients after adjuvant chemotherapy, have shown that Herceptin affords a ...pleted at least four cycles of an acceptable (neo) adjuvant chemotherapy regimen. For women with hormone receptor positive disease, adjuvant endocrine therapy (...

Other highlights in the November 2 JNCI

...ndomly assigned to be treated with 2 or 5 years of adjuvant tamoxifen therapy. Among those who received 5 years of therapy, all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, but the incidence of endometrial cancer was higher compared with tho...

ECCO 13 offers new insights into patients' perceptions of cancer

...ut the ways in which cancer patients use CAM as an adjuvant to conventional treatment, and to identify the perceived value of this complementary approach, a study of 304 recently diagnosed cancer patients was undertaken with funding by the Department of Health. Patients attending two cancer centres were surve...

New treatment options for patients with prostate cancer

... evaluated which patients would benefit from early adjuvant anti-androgen therapy. Data was presented on a new compound to treat androgen independent prostate cancer. An Australasian study reviewed the benefits of administering maximal androgen deprivation treatment before radiotherapy. The Dutch study, a mul...

Optimal adjuvant radiation therapy associated with improved survival, meta-analysis shows

A new analysis of adjuvant radiation therapy in women with breast cancer following mastectomy is associated with better survival as measured at 10 years when appropriate doses and fields of radiation are used. The study was published in the January 4 issue of the Journal of...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

...uch as tetanus, are typically administered with an adjuvant and can confer immunity for years. Dr. Smallshaw is currently determining whether the vaccine protects against aerosol and oral administrations in mice. "In a recent series of experiments, we have shown that the vaccine protects mice against lethal ...

Botox could help target resistant tumors for treatment

... cosmetic treatment Botox may have a new use as an adjuvant to cancer therapy, providing an open door for chemotherapy and radiation treatments, according to a study published in the Feb. 15 issue of Clinical Cancer Research. The study in mice, led by Bernard Gallez, Ph.D., professor of pharmacy at the Unive...

Study finds shifts in treatment trends prior to publication of study results

...a were presented suggesting that use of taxanes as adjuvant therapy could improve survival in women with lymph...Leukemia Group B (CALGB) Study 9344 suggested that adjuvant treatment with the taxane drug paclitaxel is associated with improved survival in women with lymph n...

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(Date:8/27/2014)... Gamblers are greedy bird-brains, University of Warwick research finds ... when they make risky decisions, new research has shown. ... University of Warwick,s Department of Psychology, conducted tests that ... more likely to gamble for high-value than low-value rewards. ... argue that the test results show the important role ...
(Date:8/26/2014)... a colony of harmful bacteria, biofilms make the ... in a biofilm pose a significant health risk ... treatment, and biofilm-protected bacteria account for some 80 ... are 50 to 1,000 times more resistant to ... we may have stumbled onto a magic bullet," ...
(Date:8/26/2014)... pressure from policymakers, consumers, and suppliers has prompted ... reducing the pollutants they emit from their smokestacks ... must also assess environmental performance at every step ... materials to the use and recycling of their ... the discipline known as life cycle engineering, which ...
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