Full-year results from Oxford Open show wide variation in open access uptake across disciplines
... Open to help foster a better understanding of the advantages and disadvantages of open access and subscription-based business models. These results show that while open access is beginning to be embraced in some subject areas, the level of uptake is generally quite low. These results continue to suggest that ...GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
...nior scientist at GlycoFi. Yeast offers numerous advantages as a recombinant protein expression system when compared to mammalian cell culture. These include the capability of producing higher recombinant protein titers, shorter fermentation times, and the ability to grow in chemically defined media, without ...Dartmouth and GlycoFi report full humanization of therapeutic proteins from yeast
...rt the researchers, the technology offers numerous advantages over the conventional use of mammalian cell cultures, namely reduced risk of contamination by pathogens and infectious agents along with improved drug performance and manufacturing efficiency. "Humanizing glycosylation in yeast was a tour de force...Do green markets actually lead to improvements in environmental quality?
...e them out, provide new insight into the potential advantages and disadvantages of green markets as a decentralized mechanism of environmental policy." Many governments, nongovernmental organizations, and industries promote green markets as ways to encourage private giving to environmental causes. Kotchen fin...Transplant cures rats' type 2 diabetes without need for immune suppression drugs
...rk just like a normal pancreas," says Rogers. The advantages of transplanting insulin-producing cells has also led to decades of research into transplantation of human pancreas and islets, the cells that produce insulin. Unfortunately, donor organs are so scarce that transplantation is an option for only a ten...Penn to host Herbal Medicine Symposium
...tion. "This is an excellent chance to explore the advantages and disadvantages of herbal medicine in a scientific way," said Dr. Arthur Rubenstein, MBBCh, Dean, School of Medicine, Executive Vice-President of the University of Pennsylvania for the Health System, and whose remarks will open the second day of sy...News tips from the Journal of Neuroscience
...s system in Caenorhabditis elegans provides some advantages in elucidating the molecular and cellular underpinnings of learning and memory. At least in captivity, worms memorize their cultivation temperature and move toward it when placed in a temperature gradient, but they learn to avoid that temperature if ...Test helps identify patients with breast cancer who will likely benefit from chemotherapy
...mor cells, then, may have both growth and survival advantages if p66 Shc levels are low." Chemotherapy-mediated killing of tumor cells, however, does not require p66 Shc, Frackelton said, suggesting that patients whose tumor cells have low p66 Shc might respond well to chemotherapy. To test this idea, the re...ESA's microsatellite playing major role in scientific studies
...tellite missions. The need to better promote the advantages of the mission to a still wider scientific audience, since the CHRIS/Proba community is relatively small and select, was also highlighted at the workshop. To this end, Proba Scientific Investigators are invited to submit their contributions to the 20...ACS News Service Weekly PressPac -- Sept. 20, 2006
...actions, even though the isonitriles have distinct advantages over other ingredients. In addition, existing recipes for making isonitriles require use of hazardous compounds. Michael C. Pirrung and Subir Ghorai, of the University of California at Riverside, now are reporting development of a new family of ison...Scientists use an 'ice lolly' to find polar bacteria in their own backyard
...ht to be tolerant to cold and could therefore have advantages for snow-making in artificial environments such as ski centres and in waste-water purification. "Selecting for rare microbes that seem to stick to ice has been fun, but now the real work begins to find out what genes are responsible for this attract...Bacteria for better ice cream and artificial snow no longer depends on trek to poles
...ht to be tolerant to cold and could therefore have advantages for making snow in artificial environments such as ski centres, and in waste-water purification. "Selecting for rare microbes that seem to stick to ice has been fun, but now the real work begins to find out what genes are responsible for this attra...Discovery of the first resistance gene to rice yellow mottle virus
...l gene by transgenic techniques does not bring any advantages compared with the use of natural resistance. This research can find applications in ways of improving rice production in countries hit by RYMV. Already, the IRD has transferred the gene Rymv1, by crossing, into some agronomically important varieties...Researchers make nanosheets that mimic protein formation
...ials and devices, self-assembly offers substantial advantages over traditional manufacturing approaches, if we can design the building blocks appropriately. This is what we're trying to do."...Dartmouth researchers find a neural signature of bilingualism
...netic resonance imaging or 'fMRI,' but has several advantages over fMRI," says Shalinsky, the study's electro-neurophysiologist who created the analysis programs to use NIRS technology in this new way. NIRS technology is quiet, small and portable. It's only about the size of a desktop computer. It's child frien...Study offers innovative profile of enzyme that aids tumor growth
...cer. According to the study, one of the primary advantages of the functional proteomic technology employed (activity-based protein profiling) is that it can be used to identify inhibitors for uncharacterized enzymes like KIAA1363. Moreover, because inhibitors are screened against many enzymes in parallel, bo...New biochip helps study living cells, may speed drug development
...stroyed in the process, he said. There are several advantages to retaining live cells, he said, such as being able to conduct additional tests or monitor them as they grow. "The current technology being used in research labs is very slow and difficult," said Porterfield, who believes the new chip could help d...Orexigen reports positive phase II results for Excalia Combination-Therapy to treat obesity
...ary treatment interval Excalia was associated with advantages over both the individual components and placebo (see table below). Study completers had lost in excess of 9% of their baseline body weight by week 24. Completer Analysis Excalia: -9.2% Zonisamide + Placebo: -6.6%(p=0.025) Bupropion + Placebo: -3.4...New study warns against linking ethnic identity to breast cancer genes
.... While the authors recognize the public health advantages of focusing genetic research on ethnic groups, "Our major concern is the largely unacknowledged disadvantages," Rothman said. "Serendipity may initiate a scientific quest, but should it continue to drive it--and to whose benefit?"...Research linking Ashkenazi Jews and breast cancer genes beset by problems
...e. While the authors recognize the public health advantages of focusing genetic research on ethnic groups, "Our major concern is the largely unacknowledged disadvantages," Dr. Rothman said. "Serendipity may initiate a scientific quest, but should it continue to drive it--and to whose benefit?"...