Mouse study: 'Critical' Down syndrome region isn't
...e of its other common traits. Down syndrome, which affects roughly 1 in 700 live births, is the most common g...just one of the hundreds of genes on chromosome 21 affects development no longer holds up," says Roger Reeves, Ph.D., professor of molecular biology and geneti...Single genetic defect links many risk factors for heart disease and stroke
...erol, and other metabolic disorders. The mutation affects the genes of the mitochondria the energy-producing power plants of the cell that are passed from mother to offspring. The researchers are hopeful their discovery could help unravel the complex genetic and environmental factors that cause a range of ...Latest buzz in research: Intoxicated honey bees may clue scientists into drunken human behavior
... on human behavior, a new study suggests. "Alcohol affects bees and humans in similar ways it impairs motor ...el for learning more about how chronic alcohol use affects humans, particularly at the molecular level. "The honey bee nervous system is similar to that of ver......disease. Autism is a devastating disorder that affects two to six of every 1000 children--mostly boys. Autism actually encompasses a wide array of symptoms--called autism spectrum disorder (ASD)--including various degrees of behavioral, developmental, and sensory deficits. Many people first became aware ...Early life stress harms mental function and immune system in later years
...ats that stress during the last third of pregnancy affects the ability of adult offspring to respond to challenges to their immune system. Heather Richardson, PhD, and her colleagues Soon Lee, PhD; Dong Seo, PhD, and Catherine Rivier, PhD, at the Salk Institute in La Jolla, Calif., found that the changes in ...Pesticides may promote Parkinson's disease and exercise may offer protection
...f this serious and disabling brain disorder, which affects about 1 million people in the United States. Knowledge of the environmental factors and genetics of this illness has allowed investigators to create models of disease that are being used to examine potential causes of neuron disease and to test exper...Immune system in a bottle could help prevent flu vaccine shortage
...reign invaders. "The uniformity of the environment affects the way the cells are developing," Kotov said. "This is particularly relevant for stem cells and other cells that can differentiate. These scaffolds offer a very good control over the environment." The final goal of the DARPA project will be replicat...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
... with diabetes develop neuropathy, which generally affects the sensory neurons within the peripheral nervous system and is characterized by such symptoms as numbness, tingling, pins and needles or loss of sensation, most often to the legs and feet. As a result, patients may be unaware of the presence of ulce...Stress impairs thinking via mania-linked enzyme
...tive symptoms, as occurs in bipolar disoder, which affects two million Americans. Abnormalities in the cascade of events that trigger PKC have also been implicated in schizophrenia. Amy Arnsten, Ph.D. and Shari Birnbaum, Ph.D. of Yale University, and Husseini Manji, M.D., of NIMH, and colleagues, report on ...Gene found to defend against environmental pollutants and pulmonary emphysema
...hronic obstructive pulmonary disease (COPD), which affects more than 16 million Americans and is the fourth highest cause of death in United States. COPD, the only disease among the top 10 causes of death with a rising incidence rate in the United States, is predicted to reach worldwide epidemic proportions....Gene that blocks free radical damage protects against emphysema
...station of chronic obstructive lung disease, which affects more than 16 million Americans and is the fourth highest cause of death in the United States. This disease is primarily cigarette smoke induced, but oxidative stress, a harmful condition that occurs when there is an excess of free radicals, has recen...JCI table of contents November 1, 2004
...station of chronic obstructive lung disease, which affects more than 16 million Americans and is the fourth h...at SEMA3F is a strong inhibitor of metastasis that affects both tumor and stromal cells, which suggests that it may have therapeutic potential. TITLE: Semaphor...Food shortages threaten Antarctic wildlife
...ich feed on krill. By knowing how the environment affects this unique food web, we can predict how it will respond to future change....Researchers discover transport molecule that allows boron into cells
...d leave the cell. The movement of these molecules affects numerous essential cellular functions. Like other nutrients, cells must transport boron across the membrane to control its concentration within the cell. The discovery of NaBC1 may help scientists understand how cells control internal boron concen...Cell enzyme may help suppress cancer development
...p in the level of the PTPRO enzyme. That, in turn, affects certain proteins that PTPRO acts on, furthering the cancer process. When the loss or silencing of a gene contributes to cancer, the gene is called a tumor-suppressor gene. That is, the normal activity of the gene suppresses cancer development. ...International marine survey of coral death
... populations. They have begun to learn how disease affects coral community structure and diversity. "Ultimately this concerns the human community," says Susan M. Merkel, a Cornell microbiologist and coordinator of the project. "If we find that improvements in waste-water treatment, solid-waste disposal and ...Asymmetric organs and microRNA-directed DNA modification
...er the microRNA complementary site in the PHB mRNA affects the chromatin state of the PHB gene, we assayed the PHB gene for the extent of methylation in wild-type and in phb-1d mutants," explains Dr. Barton. The researchers found that PHB and PHV coding sequences were heavily methylated downstream of the mi...Genetically engineered corn poses no immediate threat to Mexican crops
...rmine how transgene accumulation through gene flow affects the fitness and yield of the plants receiving these transgenes. Educating Mexican citizens about possible benefits and risks of GM corn. Encouraging better international coordination of regulatory policies, so GM crops that are released in our co...Study links polycystic ovary syndrome with early vascular changes of heart disease
...cterized by metabolic and endocrine abnormalities, affects millions of women in the United States alone and e...th and illness." PCOS is a common disorder that affects up to 7 percent of the female population, or about 10 million women in the United States. Some estim......es. "We'd like to develop a drug that only affects the Notch2 pathway, since blocking other members of the Notch family may actually have the opposite effect and encourage cancer growth," says Xing Fan, M.D., Ph.D., first author of the study and postgraduate fellow at Johns Hopkins. In 25 of 30...