Iron exporter revealed that may explain common human disorder
...h issue of Cell Metabolism. Hemochromatosis--which affects one in every 200 to 300 people in Western populations --causes tissues of the body to become overloaded with iron. Left untreated, the hereditary disease can lead to organ failure. The new work, led by researchers at the Children's Hospital Boston an...... regulate gene expression in the testis apparently affects the ability of those organs to produce and maintain levels of sperm needed for fertility in mice, according to research done by investigators at Baylor College of Medicine (BCM) in Houston. In a report that appears today in the journal Genes & Devel...Desert plant may help treat insidious tropical diseases
...ake a person prone to infection."Sleeping sickness affects people in mostly rural areas of sub-Saharan Africa. The disease usually begins with a high fever, a rash and swollen glands and, if left untreated, can progress into the brain, where it causes inflammation, coma and, eventually, death. "The primary d...JCI table of contents April 1, 2005
...l Oncology Cholesterol adrift on a lipid raft affects cancer progression Lipid rafts are small regions in the membranes of cells that contain high levels of cholesterol. In a study appearing online on March 17, in advance of the April 1 print edition of the Journal of Clinical Investigation , Michael ...Institute for Medical Research scientists identify gene critical to type 1 diabetes
...common form of the disease, type 2 diabetes, which affects an estimated 16 million Americans. Developing the compound into a long-acting oral drug for people and testing its safety and effectiveness would take years, the scientists caution, as would gene therapy....Chemists identify key gene in development of type 1 diabetes
...lin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they say could lead to new drug interventions and possibly gene therapy, today at the 229th national meeting of the American Chemical Society, the...Leaders in sickle cell research meet in Cincinnati
...l 1 by calling 513-281-4450.) Sickle cell disease affects approximately 72,000 Americans, most of who are of...le Eastern descent. The disease disproportionately affects African Americans one in every 400 as compared to one in every 1,000 to 1,400 Hispanics. Researche...NASA study finds soot may be changing the Arctic environment
...d sunlight. Airborne soot also warms the air and affects weather patterns and clouds. Koch and Hansen?s results suggest a possible mechanism behind the satellite-derived observations of Arctic climate change. They found the timing and location of Arctic warming and sea ice loss in the late 20th century are...Wine, music and schizophrenia genes
...res. Schizophrenia is a chronic brain disease that affects more than 2 million Americans and as many as 51 million people worldwide. Dr. Linda Brzustowicz, an associate professor of genetics at Rutgers, The State University of New Jersey, a board certified psychiatrist and an associate professor of psychiat...Gene variations explain drug dose required to control seizures
...e time to determine because of the drug's variable affects on patient metabolism and its potential neurologic side effects. The team identified genes considered to be obvious candidates underlying patients' drug response, based on their known roles in the metabolism or transport of one or both anti-epileptic...Separate genes influence speed, accuracy in decoding written words in dyslexia
...lts. Dyslexia is a complex learning disorder that affects 5 to 10 percent of school-age children in the United States. It typically is characterized by early difficulties in learning to name letters and associate sounds with letters. Later on, children with dyslexia have difficulty pronouncing real words ...Two-part blood pressure control suggests new approach to hypertension therapy
...ed methods for treating high blood pressure, which affects nearly one in three American adults. The findings further suggest how the underlying causes of high blood pressure may vary among patients, with some cases resulting from kidney abnormalities and others from abnormalities in other areas, such as the ...JCI table of contents April 1, 2005
...uthors use mice lacking Ikaros to show that Ikaros affects the development and function of the stress systems in the brain. This function of Ikaros parallels its already known role in immune cells. In an accompanying commentary, George Chrousos and Tomoshige Kino write, "the findings of Ezzat, et alsuggest...Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
... it work, and why? Necrotizing enterocolitis (NEC) affects some 10,000 infants annually in the U.S., and over 90% are formula-fed before onset of NEC. At greatest risk are small, premature infants, and infants fed concentrated formulas. Estimates of mortality vary widely, up to 40%. International rates of ...SERPINE2 identified as novel candidate gene for COPD, especially with smoking
... this line of investigation will show how SERPINE2 affects the risk of developing COPD and how smoking contributes to this process," he added. In the future, Srisuma will pursue a project identifying potential biomarkers in COPD patients from New England and also in his native Thailand. When he completes hi...Estrogen, SERMS reduce asthma impact by halting constriction
...ymptoms, strongly suggesting that perhaps estrogen affects airway smooth muscle function by preventing the hyperresponsiveness characteristic of asthma and other chronic lung diseases. Now, scientists at the Medical College of Georgia have shown that elevated estrogen levels may reduce the severity of asth...In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage
...t the inflammation associated with asthma directly affects the heart's recovery from a heart attack, confirming the growing body of evidence that indicates asthma may directly, and negatively, impact the cardiovascular system. "The findings are clinically important because they provide the first evidence of ...Pediatric burn victims' recovery, diabetes, metabolism aided by fenofibrate (Tricor)
...t metabolism. However, acute burn trauma seriously affects both glucose and fat metabolism, and our results show that by increasing cell mitochondrial fat metabolism with fenofibrate (marketed as Tricor by Abbott Laboratories), glucose metabolism can also be improved," Cree reported. *Paper presentation: "F...14 highlighted physiology papers from IUPS 2005: From 'genomics to functions'
...t the inflammation associated with asthma directly affects the heart's recovery from a heart attack, confirming growing evidence that asthma may directly, and negatively, impact the cardiovascular system. If the clinically important findings are confirmed, asthma could be identified as a potential risk facto...Researchers pioneer new gene therapy technique using natural repair process
...acy means that, in practice, the gene therapy only affects the mutant gene. Homologous recombination is a fairly rare event that occurs when DNA strands of one chromosome break, creating a damaged section. Cells have two copies of nearly every chromosome (one each from the mother and father) and they must...