Purdue scientists treat cancer with RNA nanotechnology
...ery vehicles that can carry anticancer therapeutic agents directly to infected cells, offering a potential w... an efficient system to bring multiple therapeutic agents directly into specific cancer cells where they can perform different tasks," said research team lead...Molecular pathway linked to breast cancer recurrence
...ieve that treatment of patients with pharmacologic agents that block Snail expression or function may be a promising approach to preventing breast cancer relapse. Snail may thereby represent an important target for a new generation of cancer therapeutics directed against specific molecules involved in breas...Study in Royal Society journal on possiblity of human organ regeneration
...t medical researchers can identify the appropriate agents (scaffolds, small molecules, etc.) that awaken the early foetal response to injury. The emerging field of Regenerative Medicine is based on this new treatment that leads to organ regeneration and provides an outlook toward increased longevity. Contac...Gene therapy to lower blood pressure just enough
... reducing the manner in which the vessels react to agents that can constrict those vessels. ANP also improves the manner in which the kidney eliminates sodium or salt from the body and inhibits other systems, such as the sympathetic nervous system, believed linked to development of high blood pressure. "T...Engineered molecule amplifies body's immune response
...immune system in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. Recently, interferon has also been shown to play a role in the body's surveillance against the development of cancer. Because of this role, recombinant interferon is often used for the treatment o...Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
...ody's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis. "Essentially, we found a way to grease the gears that drive the interferon signal," says Mich...Phytochemicals may protect cartilage, prevent pain in joints
...hase 2 enzymes can detoxify certain cancer-causing agents and damaging free radicals in tissue, including cells that line blood vessels. He has isolated compounds in edible plants that boost production of phase 2 enzymes. These phytochemicals can be found in cruciferous plants, including broccoli. Talalay p...Burnham Institute to collaborate in NCI funded Center of Cancer Nanotechnology Excellence
... be use as a postal address for delivering imaging agents and cancer therapeutics. The project directed by Dr. Ruoslahti aims to develop nanodevices that can act as mailmen for delivering these payloads directly to the blood vessels of cancer cells. Dr. Tomas Mustelin, Professor and Director of the Institut...$16 million grant advances nanomedicine at Washington University
...or site, the nanoparticles can deliver therapeutic agents to destroy the tumor. To advance this promising te...s that can home in on tumor cells to carry imaging agents and drug therapies directly to tumor sites. Lanza is associate professor of medicine and a cardiolog...A novel mechanism of action for anti-tumor agent, CA4P
Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only se...Egg's energy stores key to preserving fertility
...ents oocytes from dying, even in response to toxic agents like chemotherapy drugs, said Seth Margolis, Ph.D., a study co-author and postdoctoral researcher in Duke's department of pharmacology and cancer biology. Also, female mice missing the gene to produce caspase-2 are born with an excess number of oocyt...JCI table of contents November, 2005
... ACTION FOR LEAD ANTI-TUMOR AGENT Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only se...Report focuses on challenges to unlocking future promise of vaccines
... The report identifies over 40 infectious agents that pose significant human health problems in the...st significant of which is HIV. Of the infectious agents identified, only 12 currently have effective vaccines. In addition, the report also identifies a nu...W.M. Keck Foundation grant advances study of biocompatible liquid crystals
...re used for controlled drug delivery and reporting agents of certain biological activities. Serious scientific inquiry evaluating the relationship between liquid crystal properties and biological function began in the 1970s but was abandoned in favor of emerging research and economic opportunities presen...Fetal exposure to toxins could be behind rise in asthma
...es later in life. Yet, the same low doses of these agents do not impair an adult immune system, Dietert said. "I think this goes a long way toward explaining the epidemic rises in allergies and autoimmune disorders," said Dietert. When an infant's immune system remains biased toward Th2 responses because of...AIBN researcher granted top fellowship
...racting funding for their research into novel drug agents involved in the development of blood vessels. Professor Campbell also won another grant with a vascular surgeon collaborator, Dr Jon Golledge, from James Cook University in Townsville....Cowpeas could add sustainability to cropping systems
...k with producers and (Texas Cooperative) Extension agents to see how it works into a production system," he said. "Timing of pasture availability will be important. We want to try to time its availability with the greatest demand, so there are still things to work out."...Complementary new titles offer comprehensive view of antibiotics and resistance
...ylococcus aureus. Also examined are antimicrobial agents that are in advanced states of development, products that are used on animals, agents that are as yet unexplored, and those for which development has ceased. All existing chapters have ...Humble yeast sheds light on promising anti-cancer drug
...less prone to resistance than the chemotherapeutic agents that target the tumour cells. While GSAO would not "cure" people of the cancer, it should stop most types of tumours in their tracks. This means that the focus of cancer treatment and research could move away from curing the disease to one of manag......ment--and discuss their effectiveness as antitumor agents in phase I-III clinical trials. The authors point out areas for future research and emphasize the need to develop assays for genome-wide and tumor-specific DNA methylation to maximize the therapeutic efficacy of these compounds. Contact: Julia Rauten...