Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...s proteins to prevent and clear pathogenic protein aggregates in Alzheimer's disease" Dr. Graefs research focuses on the creation of a molecule that is able to attach itself to a chaperone, an abundant cellular protein that helps other proteins to fold properly. These new compounds can tether bulky chaperones ...Microbes at work cleaning up the environment
...itially occurred rapidly to 100-nanometer diameter aggregates but then slowed or ceased after one week. However, zinc-sulfide nanoparticles in the presence of cysteine displayed more extensive and prolonged aggregation, accumulating up to 1-10 micron (1/1000th of a millimeter)-sized structures. Potentially w...In nature, proteins sweep up nanoparticles
...d spectroscopy, the team analyzed the zinc sulfide aggregates and detected the characteristic signal of proteins. Next, to further zero in on this intriguing signal, they examined the sample using an extremely high-spatial-resolution imaging tool called secondary ion probe spectrometry, which is located at th...Assumption of function not always correct
...mbination. In this kind of repair, one chromosome aggregates with a partner chromosomeusually its twin chromoso...hen disaggregates following repair. If the repair aggregates are not unzipped, the chromosomes can't separate for reproduction. The yeast and human Werner syndro...New studies link the environment to Parkinson's disease
...ion of harmful proteins. Intraneuronal protein aggregates as markers of Parkinson's pathology, based on work...at The Parkinson's Institute indicating that these aggregates could be formed as a consequence of toxic exposure. The importance of targeting a specific prote...Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
...ly new finding is that PH domain proteins can form aggregates through their PH domains. PH domain aggregation may enhance the membrane binding process." Sauer suggests models for how IP4 might augment the binding of PIP3. In one, IP4 binds to a PH domain, changing its structure to one with a high affinity fo...JCI table of contents -- March 8, 2006
... mice were stimulated in vitro they formed smaller aggregates than platelets from normal mice. This study therefore identifies a new function for SHIP1 in regulating platelet function to sustain normal hemostasis. TITLE: Deficiency of Src homology 2 domaincontaining inositol 5-phosphatase 1 affects platelet r...Proteasome activator enhances survival of Huntington's disease neuronal model cells
...ity is inhibited and intraneuronal nuclear protein aggregates of mutant huntingtin in HD brains indicate dysfunction of the UPS. From these results, we hypothesized that enhancing UPS function would improve catalytic degradation of abnormal proteins in HD. We first genetically engineered proteasome activators i...NIH funds innovative alzheimer's research initiated at UCSB
...c discoveries indicate that these large, insoluble aggregates might merely be markers of the disease they do not cause the disease. Rather, smaller soluble oligomers, or peptide complexes, are now felt to be the causative agents, and I find that very interesting. He explained that now the hunt is on for the...Wiley Foundation announces recipients of 6th annual Wiley Prize in Biomedical Sciences
...pe, thereby preventing the accumulation of protein aggregates that underlie many diseases, such as Alzheimer's and Parkinson's. "The Wiley Prize is being awarded to Dr. Hartl and Dr. Horwich for their significant contribution in protein folding," said Dr. Gnter Blobel, Chairman of the awards jury for the Wil...Destructive enzyme shows a benevolent side
...e cell survives. Stress granules are short-lived aggregates of mRNA and proteins, and they accumulate when cells are subjected to conditions such as starvation, low oxygen (which can occur within large tumors), chemotherapy or radiation therapy. The study, led by researchers at Ohio State University's Compr...A fisheye view of the deadliest breast cancer
...ells homed in on blood vessels, forming tumor-like aggregates and tapping into the fishs circulatory system by inducing an angiogenic response. A separate fluorescent labeling allowed the researchers to simultaneously monitor the parental MDA cancer cells and the RhoC-overexpressing tumor cells in the contex...Researchers study role of natural organic matter in environment
...e same ion, creating much larger aggregates. These aggregates are responsible for the formation of bio-fouling layers on membrane surfaces. In addition to clogging filters, natural organic matter can change the mobility of certain toxic metals in soil and water. "We performed our experiments and computer si...Yeast model shows promise as Alzheimer's test
...lzheimer's, recent research points at much smaller aggregates of the peptide as the culprit. "We've developed a...of Alzheimer's disease is to prevent these smaller aggregates from forming," said Liebman. "Disruption of these small aggregates rather than the larger fibers see...Scientists design simple dipstick test for cocaine, other drugs
...ption. The appropriate aptamer-linked nanoparticle aggregates are placed on the conjugation pad, streptavidin is... wicking pad carries the fluid to the nanoparticle aggregates on the conjugation pad. The rehydrated aggregates then migrate to the edge of the membrane, which th...News tips from the Journal of Neuroscience
...ellular dopamine concentrations and an increase in aggregates containing -synuclein. Mutations in the gene encoding -synuclein are responsible for some cases of familial PD. A number of factors can affect the initiation of synuclein fibril formation. In cell-free systems, dopamine interacts with -synuclein and ...UW-Madison work on stem cells, cardiac health to be presented at ACS
...with a substance that absorbs protein, so the cell aggregates will grow inside the wells, while the area outside...ferent sizes and shapes, so that larger or smaller aggregates can be cultured. "When you culture stem cells in these very small microwells, we can actually contr...Scientists discover age-regulated cellular activities that protect against protein aggregation
...otective mechanism enables the formation of larger aggregates from smaller ones that appear to be more toxic. ...selectively inhibited DAF 16, there were almost no aggregates observed," Kelly says. "That clued us in to the fact that these two transcription factors must be co...New research points toward mechanism of age-onset toxicity of Alzheimer's protein
...trous consequence of aging or if the toxic protein aggregates that cause the disease simply take a long time to ...hat aging is what's critical. Harmful beta amyloid aggregates accumulate when aging impedes two molecular clean-up crews from getting rid of these toxic species. ...UCLA scientists strengthen case for life more than 3.8 billion years ago
...a "signature of life," Mojzsis said. The carbon aggregates in the rocks have a ratio of about 100-to-one of 12C (the most common isotope form of carbon, containing six protons and six neutrons) to 13C (a rarer isotopic form of carbon, containing six protons and seven neutrons). The light carbon, 12C, is more...