Pushing the envelope to overcome HIV drug resistance
... the way these drugs work. Protease inhibitors are all small-molecule, competitive, active-site inhibitor...fine the three-dimensional shape that is shared by all the substrates as they are bound in the active site. They then go on to define an "inhibitor envelop...The long road to a promising malaria vaccine started at NYU School of Medicine
...e response against the CS protein, which occurs in all of the various species of the parasite called Plasmodium causing malaria. They found that the CS protein coats the parasite when it is in the salivary glands of the Anopheles mosquito. At that stage it is a crescent-shaped and called sporozoite, a st...Scientists identify new cause of obesity
... no single treatment is likely to be effective for all obese people. Still, MC4R must be a central player, he says, since mutations that cause even subtle changes in this protein now appear sufficient to increase food intake, ultimately leading to obesity. "Clearly, this receptor is crucial to the body's...Research gaining momentum by silencing genes
... contribute to the elucidation of the functions of all the genes in this model organism. Furthermore, thi...ng on a collection of 'inactivating' fragments for all Arabidopsis genes. The current collection contains fragments designed to inactivate more than 20,000...Multi-species herbivore outbreak follows El Nio drought in Panama
Plant-eating insects inhabit all forest ecosystems, but sometimes their numbers explode, resulting in massive tree defoliation. In the October issue of the Journal of Tropical Ecology researchers from the Smithsonian Tropical Research Institute (STRI) associate a severe moth outbrea...Researchers redrawing the Tree of Life
...e 270,000 species of flowering plants that include all our food plants. The NSF grant allows scientists ...ers, including Hilu's work on the mat-K gene. Then all the data generated at the seven labs will be combined and computer analyzed, a tree of life for flow...Hepatitis C virus linked to non-Hodgkin's lymphoma
...ety of NHL, comprising approximately 30 percent of all NHL patients. Compared to Europe and Japan, incidence of hepatitis C viral infection is fairly low in North America, and previous studies from Canada and the United States have not shown an association between the virus and development of NHL, said ...Study confirms link between head and neck cancer and common Asian nut
...ted by the act of chewing betel quid, can be found all over the ground and on public buildings. Also con...he other hand, usually reflect factors that affect all age groups equally at a given period of time, such as introduction of new diagnostic or therapeutic ...UCLA scientists discover new way to fix defective gene
...rmal cells that can't function properly, producing all of the neurological and immune problems that afflict A-T patients," said Lai, the study's first author. Lai and Gatti noted that A-T patients whose cells contain no ATM protein suffer from a severe form of the disease, while patients whose cells ho...Rutgers is on the 'NIH Roadmap'
... and very urgent needs remain. NIH is now drawing all fields of science together in a concerted effort to meet these challenges head-on." In this spirit, one of the new grants was awarded to a group of 34 Rutgers and UMDNJ faculty members from the BioMaPS (Biological, Mathematical, and Physical Science...Biomedical engineers at case develop first sliver-sized sensor to monitor glucose levels
...elf that a sensor like a sliver would be ideal for all kinds of biomedical applications since the skin would heal very quickly above it and after that no track infection can occur. The associate professor of biomedical engineering and researcher at the Case School of Engineering has developed for the fi...Zebrafish may offer researchers powerful new tool for studying innate immunity
... -- For the first time, researchers have sequenced all 36 genes of novel receptors that appear to play a critical role in the innate immune protection of zebrafish an achievement that could lead to a better understanding of infectious diseases and certain cancers. Their paper, titled "Resolution of the...Peakadilly nv biopharmaceutical firm created
...roteomics technology Proteins are responsible for all life processes in our cells - regulating the diges...ce for this. The technology enables one to uncover all the differences between the proteome of a sick person and that of a healthy person, and between the ...Manipulation of epigenome turns off as many genes as it turns on
...Hopkins has discovered. "We don't know what effect all these changes might have, but it's clear that when... While the number of affected genes differed, all of the methods turned off as many genes as they turned on, including entire gene families that might...Hormone therapy's effect on breast density is not the same for all women, Group Health study finds
...asn't been clear whether this increase happens for all women, or whether it differs based on various breast-cancer risk factors, the type of HT a woman uses, and the length of time she takes it. A new study, conducted by Erin Aiello, MPH, and colleagues at Group Health Cooperative's Center for Health Stu...High fiber intake reduces estrogen levels in Latina women, according to researchers
...who had the highest and lowest intake levels among all the Mexican-American women. In the end, Monroe and her colleagues--including Laurence N. Kolonel and Suzanne Murphy, professors at the Cancer Research Center of Hawaii, Brian E. Henderson and Malcolm Pike, professors of preventive medicine at the ......la term for more than 100 medical conditions. What all forms of arthritis have in common is that they affect our joints--places where two or more bones meet. In healthy joints, the ends of the bones are covered with cartilage, a tough but smooth tissue that, like the oil in a car engine, reduces friction...Two UT Southwestern physicians elected to National Academy of Sciences' Institute of Medicine
...ry," Dr. Hobbs said. "I am especially thankful for all the support I have had from my colleagues here at UT Southwestern and for the work of the individuals in my lab." Dr. McConnell, an internationally recognized authority in prostate disease, is responsible for the overall management of univers...Experimental lupus drug may also work against atherosclerosis
...Elene Boudyguina, B.S., and Doris R. Brown, Ph.D., all at Wake Forest Baptist, and Samantha Laclair. B.S., and Uwe Schonbeck, Ph.D., of Brigham and Women's Hospital of Harvard Medical School in Boston. ...To save dolphin's dorsal fin experts combine medical technology and teamwork
...hins in the future and many, many other animals of all kind, as Liko's story helps introduce the concept ...e sequence of fin-saving treatments to follow. But all agree the most important member of the dolphin's expert medical team is Liko, himself. The young dol...