Gene linked to greater risk of heart disease in type 2 diabetes
...levels of free fatty acids and triglycerides. When all five variants were factored together, a strong link emerged -- the highest levels of fatty acids and triglycerides occurred in people with a specific variant combination. Using this new knowledge as a basis for a second study, they studied 518 people...Gene-altered mouse is model for rare autoimmune syndrome
... Indeed, he said, the mice lacking the gene had all the characteristics of the disease, including reduced tear and saliva secretion and infiltration of lymphocytes into their tear and salivary glands. The animals also showed production of the antibodies that indicated the immune system was activated t...Promising new preventative treatment option for population of men at high risk of prostate cancer
...ention Research, scientists found that patients at all dose levels for toremifene had a lower cumulative incidence of cancer after 12 months of treatment, with the 20 mg dose contributing the greatest effect. All participating patients had high-grade prostatic intraepithelial neoplasia or PIN, charac...Leading scientists to discuss research applications for therapeutic cloning
...the Magee-Womens Research Institute. "But a ban on all forms of human cloning sends the wrong signal to t...e U.N., the United States is pressing for a ban on all forms of human cloning, while Belgium heads a faction seeking a ban on reproductive cloning but with...Mice thrive despite massive genetic makeover
...of the human genome, a question still lingers: is all the non-coding DNA (sometimes called "junk DNA")--which makes up nearly 98 percent of the genome--required, or is some of it potentially disposable? "In these studies, we were looking particularly for sequences that might not be essential," said ...Genetic data crunching achieves milestone at Stanford
...rieve and compare data with other experiments were all required. New information about genes spotted on t... a completely revamped database, and by April 2000 all 5,000 experiments from the old database had been transferred to the new database, officially known a...International human genome sequencing consortium describes finished human genome sequence
... analyze the human genome is the identification of all genes, which are generally defined as stretches of DNA that code for particular proteins. According to the new findings, researchers have confirmed the existence of 19,599 protein-coding genes in the human genome and identified another 2,188 DNA segm...DFG research training groups become increasingly international
...rticularly highly qualified doctoral students from all scientific disciplines since 1990. Between 15 and ...esearch and teaching. Approximately six percent of all doctoral students in Germany complete their doctorates within a Research Training Group. Graduates o...Babies born after surgery on eggs
...rred into donor eggs before fertilisation, meaning all the children's mitochondria would have come from the donor, had they survived (New Scientist, 18 October 2003, p 12). Last week, Doug Turnbull and Mary Herbert at the University of Newcastle upon Tyne in the UK applied for permission to use nuclear ...For inferring the biological tree of life, simple is better
...various parts of a gene evolve at the same rate in all species. So they evaluated, for the first time, t...yonic development among species, their conclusions all depend upon accurate knowledge of the evolutionary tree. Thornton and Kolaczkowski performed their e...OHSU study: Bacterial switching mechanism key to survival
...in's structure through X-ray crystallography helps all biomedical scientists to better understand its fun...rowing very slowly, if at all. Often times, that's all you need for the human body to mount a counter-attack to overcome a bacterial infection."...New DNA repair enzyme makes mistakes to save lives of cells
...he production of proteins, which in turn determine all aspects of a cell's structure, function and moveme...one it inserted, thereby extending the chain as if all is normal. "POL-Q's two-step actions of insertion and extension, essentially the work that would be...Mitochondrial mutation linked to blood pressure and cholesterol problems
... further, this finding raises the possibility that all features of the metabolic syndrome may be attribut...ion, the presence of the mutation does not produce all of the symptoms in each individual. While this study focuses on a rare mutation in mitochondria ...Molecular mechanism sheds light on neurodegenerative diseases
...ior. Misfolded and damaged proteins are common to all human neurodegenerative diseases. They clump together to form toxic aggregates that destroy cell function and cause disease. Morimoto's team is the first to demonstrate in living human cells and in real time that the toxic protein aggregates, in this...ENCODE consortium publishes scientific strategy
...nd its quest to produce a comprehensive catalog of all parts of the human genome crucial to biological fu...g its ambitious goal of building a "parts list" of all sequence-based functional elements in the human DNA sequence. The list will include: protein-coding ...Mouse study: 'Critical' Down syndrome region isn't
... this replicated segment is found in triplicate in all people with segmental trisomy and Down syndrome's ...e with only two copies of DSCR but three copies of all other genes on mouse chromosome 16. That "hybrid" mouse was similar to its Down syndrome parent but ...Single genetic defect links many risk factors for heart disease and stroke
..."Not everybody who has any one of these traits has all of the others. The pattern of inheritance is compl...ggested that she might have a new disease, because all the known genetic causes of low magnesium were autosomal recessives that would not occur so widely."...Are yeast cells bringing us a step closer in treating obesity?
...ort sugar in the blood, is of major importance for all the cells in the body. Glucose is not only absorbed and metabolized by the cells - it also regulates many cellular reactions. When too much or too little glucose is present in the blood - as in diabetes, for example - this process can break down. The...Researchers discover gene mutations for Parkinson's disease
...fied a small region of the chromosome 12 shared by all of the Basque families and then systematically assessed each gene in this region for mutations that might cause disease. The investigators identified two mutations in the same gene, one associated with Parkinson's disease in the Basque families and t......be science to bedside care. "We would like to link all this information so that a person doing an experiment that mimics the immune response in cell culture can integrate the gene expression and proteomics data with results from other investigators focused on clinical trials research." BioHealthBase coll...