deCODE discovers cause of major subtype of glaucoma
...ed to the identification of the two risk variants allele G of rs1048661 and allele G of rs3825942 strongly linked to XFG in Icelandic and Swedish case-control cohorts. A combined tot...Gene variant is associated with brain anatomy, clinical course of ADHD
...s studies have suggested that carriers of the risk allele [alternate form of a gene] may also have a unique ...ns, with subjects with ADHD with the DRD4 7-repeat allele having the thinnest cortex, followed by subjects with ADHD lacking the 7-repeat allele, healthy 7-re...U-M, Israeli scientists report major advance in search for genes associated with colon cancer
...cancer deaths. The specific marker is called the C allele of rs10505477. Three other research teams are reporting similar findings today in the journal Nature Genetics, having simultaneously found their way to the same small area of chromosome 8, called 8q24, in the search for colon cancer genetic links. ...Illinois researchers presenting at ASPB Annual Meeting in Chicago, July 7-11
...ndings from their Survey of splicing variation and allele specific expression in natural accessions of Arabidopsis thaliana using SNP-tilting array. Rick Williams, also a University of Chicago Ecology and Evolution lab researcher, completed research with several local and nationally-based colleagues on ano...Gene variant increases risk for alcoholism following childhood abuse
... males, says Dr. Ducci. The MAOA-LPR low activity allele appears to confer increased vulnerability to the adverse psychosocial consequences of childhood sexual abuse. Dr. Ducci and her colleagues suggest that the effect of MAOA on the hippocampus, a brain region which is involved in the processing of emo...Banding together: RAS signaling of circadian output
...cloned the band gene, and have found that it is an allele of ras-1. This finding posits RAS signaling as a key mediator of circadian output. The fungus Neurospora crassa is one of the best studied laboratory systems for circadian rhythms. However, over the past 50 years, almost all of the work done on Neu...JCI table of contents: May 24, 2007
... authors went on to show that loss of a single Shh allele in Gas1-/- mice exacerbated the facial deformities, providing evidence that Shh and Gas1 interact. The study suggests that GAS1 in humans may act as a modifier of other genes in some human craniofacial malformations. TITLE: Gas1 is a modifier for h...Major genetic study identifies clearest link yet to obesity risk
...udy found that people carrying one copy of the FTO allele have a 30% increased risk of being obese compared ...pies. However, a person carrying two copies of the allele has a 70% increased risk of being obese, being on average 3kg heavier than a similar person with no ...Researchers find gene mutation that causes infertility in male mice
...ts tracks, preventing sperm production. The mutant allele (one version of the pair of genes we inherit from ...ed the DNA of the sterile males and identified the allele that caused the infertility. While most studies on the genetics of fertility stem from analyses of m...News tips from the Journal of Neuroscience
...d by CNS glia, is perhaps best known because its 4 allele is a risk factor for late-onset Alzheimer's disease. This week, Hayashi et al. outline a signaling pathway by which these apoE-containing lipoproteins can inhibit apoptosis. The authors induced apoptosis in cultured rat retinal ganglion cells by remo...A form of the alcohol dehydrogenase gene may protect Afro-Trinidadians from developing alcoholism
...abolism. New findings indicate that the ADH1B*3 allele may protect against the development of alcoholism. At the same time, the ADH1B*3 allele may be a risk factor for liver disease most likely because it increases levels of acetaldehyde if an...The G allele of the mu-opioid receptor gene is linked to craving for alcohol
... New findings show that heavy drinkers with the G allele of the A118G polymorphism of the mu-opioid recepto...mozygous for the A allele. Individuals with the G allele may have more problems resisting the urge to drink. The study of genes and their influence on alcoh...Mutant mouse provides insights into breast cancer
...rning that one might have this cancer predisposing allele [DNA codings at a given site] because the mice live normally," said Schimenti, who is also director of the Center for Vertebrate Genomics. The researchers plan to study further the other Mcm genes to see if they, too, play a role in cancers. The Mcm ...Genetic study of Neanderthal DNA reveals early split between humans and Neanderthals
...ncy derived alleles in Europeans where the derived allele matches Neanderthal. No site in the data set appears to be of this type." However, Pritchard said, "We do not exclude the possibility of modest levels of genome admixture." Pritchard's team suggests that human and Neanderthal shared a common ancest...Genes offer researchers a 'crystal ball' to help them prevent, diagnose and treat cancer
...TM1 positive, which is more efficient than another allele type of the GSTM1 gene at detoxifying carcinogens. They found that patients with a null type at this gene were four times more likely to die within two years as were matched patients who had the positive variant. The researchers also found that...Blue eyes -- A clue to paternity
...gene (or allele) is dominant, whereas the blue eye allele is recessive. It then follows that if a child born to two blue-eyed parents does not have blue eyes, then the blue-eyed father is not the biological father. It is therefore reasonable to expect that a man would be more attracted towards a woman dis...Early family experience can reverse the effects of genes, UCLA psychologists report
...PR had two short alleles (s/s), a short and a long allele (s/l) or two long alleles (l/l) for the serotonin transporter gene. (An allele is any of several forms of a gene.) The research showed that a person's likelihood of developing ...Discovery of the first resistance gene to rice yellow mottle virus
...ice was modified by transgenically introducing the allele for susceptibility of this gene. The descendents of transformed plants that manifested restored susceptibility always showed the presence of the transgene (fig. 2). Viruses are built with a small genome coding for a limited number of proteins (5 in ...When two mutants collide: How XPD disorders can be partially rescued in compound heterozygotes
... the XPD gene, two copies of the individual mutant allele are needed for disease manifestation. However, und...terozygote mice that have the recessive mutant TTD allele on one chromosome, and a different mutant allele on the other. They linked physical traits to differ...Genetic variant is associated with higher rate of premature delivery in African-American women
...ers compared amnion samples carrying the minor "T" allele to samples carrying the major "C" allele. The minor "T" allele is a genetic variant that occurs with greater frequency among those with African ancestry. A reducti...