JCI table of contents, March 9, 2006
...d in the future to treat the recurring symptoms of allergy in humans. Specifically, the authors suggest that strategies aimed at stimulation of CD137, which has previously been shown to induce tumor rejection, may represent a clinical target for allergic inflammatory responses and other disorders characteriz......pid antigens. "In the past, most of the focus in allergy and asthma has been on protein antigens," Umetsu says. "Our current studies suggest that other classes of antigens may be involved. And since NKT cells have a receptor that varies little between mice and humans, we believe that the antigens they reco...JCI table of contents, March 16, 2006
...o dampen the immune response in conditions such as allergy and organ transplantation, which are characterized... hairy solution to the problem of inflammation and allergy During the immune response T cells attack foreign antigens directly. However, a specialized subset ...Diabetes and cancer: Alpha connection
...tion, not only in cancer but also in inflammation, allergy and auto-immunity. These mice mimic the effect of systemic administration with a p110 alpha-specific drug," According to Dr. Vanhaesebroeck, traditional mouse models investigating the function of PI3K proteins have been engineered to completely remov...Patient's generosity after death leads to possible clues for lung disease
...stitial Lung Disease in the division of pulmonary, allergy and critical care medicine at the University of Pittsburgh School of Medicine and senior author of the PLoS essay, "Lessons from Our Patients: Development of a Warm Autopsy Program." Warm autopsy a practice involving retrieval of organs within six h...Airborne mold spores increase kids' risk for multiple allergies
...face--including wood, drywall and cement. Previous allergy studies focused on visible mold or total mold conc...l particulates on childhood respiratory health and allergy development. Air samples were collected for a total of 48 hours in the child's primary activity roo...Producing flu vaccines will be faster and cheaper, thanks to MSU technology
...t of flu vaccine is lost. Plus, anyone with an egg allergy can't have the vaccine. "By growing cell culture-based flu virus, the cost and the time needed to produce the vaccine will be much lower," Coussens said. "We'll also be able to produce much more vaccine in a smaller space. And the virus that is gro...Allergy battle could be won in five years, says scientist
...fective because their effects do not 'travel' with allergy sufferers. "ADIs promise to be significantly better because taking a medicine is easier than rigorous housework and pills are portable." Professor Garrod, who is based within Manchester's Faculty of Life Sciences, said work on the first ADI chemi...Dartmouth researchers find key player in immune system regulation
...ers found that mast cells, known for their role in allergy reactions such as watery eyes and runny noses, are connected to the activity of regulatory T cells, which suppress immune responses. The researchers say theirs is the first study to find that mast cells mediate immune system suppression. "Our find...ActoGenix raises 11.5 million in series A stock financing
...ncluding gastrointestinal diseases, auto-immunity, allergy and metabolic diseases. The Company's lead product for the treatment of Crohn's disease has already been successfully tested in patients. Dr. Mark Vaeck, who joined the company as CEO, brings considerable experience in the start-up and growth of bi...Researchers receive $12.8 million NIH grant to improve diagnosis/treatment of chronic lung disease
...e need to determine is why and how some develop an allergy to it, and others do not," said Kolls, chief of Pu... be critical in determining which patients develop allergy and which patients do not develop lung damage. "Our ultimate goal is to learn if mobilization of ...Histamine tied to changes in blood pressure during exercise-recovery period
... works against H1, reducing the occurrence of such allergy symptoms as sneezing and runny nose. Ranitidine, or Zantac, acts against H2 in the treatment of acid reflux. For the study, 28 sedentary and endurance-trained men and women were monitored closely throughout a session that covered a pre-exercise per...Children of allergy sufferers prone to same problem
...ngs in a 2004 Swedish study. Using the skin-prick allergy test, the Swedish group found that in their general population--which included children whose parents did not suffer from allergies--7 percent had allergic sensitivity at age 1. The Swedes tested five allergens, two of which were food allergens. The...Friendly bacteria in alcoholic milkshake could fight food allergies
...sed to wean babies, as it is easily digested. Food allergy prevalence is especially high in children under the age of three, with around 5-8% of infants at risk. Currently the only treatment is avoidance of the problematic food. "Friendly" bacteria in kefir may play a role in blocking the pathway involved ...Key molecular signaling switch involved in allergic disease identified
...eolytic enzyme called ADAM10 that releases a major allergy regulatory protein from the surface of cells and thereby promotes a stronger allergic response. The identification of drugs that inhibit ADAM10's ability to release this molecule could revolutionize treatment of asthma and allergic disease. "Our re...Colorado company to sell medical food products based on Wake Forest discovery
...ces known to play a significant role in asthma and allergy attacks. "Through our research and clinical trials, we have learned that allergic individuals have a unique dietary need for two fatty acids, GLA (gamma-linolenic acid) and EPA (eicosapentaenoic acid)," Chilton said. "Our studies also show that incr...Infants wheeze less in homes with multiple dogs
...l particulates on childhood respiratory health and allergy development. Researchers collected dust samples...mold and second-hand smoke. Environmental and food allergy development was monitored through annual skin prick tests. Previous studies have addressed the rol...All itches not created equal -- Different parts of brain activated depending on cause
...hat different reactions in the brain to two common allergy triggers -- allergens (pollen and dust) and histamine (allergy cells within the body caused by foods, drugs or infection) -- may shed some light on the itch-scratch cycle. The Study The study is entitled Itch and Motivation to Scratch: An Inv...Other highlights in the December 20 JNCI
...iabetes, and cancer. A drug called cromolyn, an allergy and asthma treatment, has been shown to bind to proteins similar to S100P. To test cromolyns effects on S100P in pancreatic cancer cells, Thiruvengadam Arumugam, Ph.D., Vijaya Ramachandran, Ph.D., and Craig D. Logsdon, Ph.D., of the University of Tex......, they found that there was no association between allergy and the development of non-Hodgkin lymphoma. "Allergy may not be causally associated with the risk of non-Hodgkin lymphoma. The inverse association observed in some case-control studies may arise because non-Hodgkin lymphoma suppresses the immunolo...