Targeting tumors the natural way
...n their surfaces than do normal cells, a fact that allows scientists to pinpoint tumor cells lurking among the body's scores of cell types. A popular approach employs a cell-binding agent, such as a monoclonal antibody, that is powerfully attracted to the target receptor and holds fast to any cell displayin...... plates. The three-piece unit creates a shaft that allows the scissors to rotate and swivel. Driving the motion are two handles strapped with photo-responsive molecules called azobenzene, which not only has the ability to absorb light, but comes in two isomeric forms: a long-form and short-form. Upon expo...Simulated populations used to probe gene mapping
...eng developed during his doctoral studies at Rice, allows researchers to sample individuals from a simulated population and test whether statistical methods are up to the task of accurately identifying genes that interact to cause complex diseases. "Though they have much in common, the disciplines of stat...Study shows metabolic strategy of stressed cell
...one can be inhibited by rising levels of CoA. This allows the cell to increase or decrease CoA levels in specific locations, depending on the amount of CoA needed. These findings not only give researchers a detailed look at how the cell responds to a significant reduction in the concentration of a critic...Genetic studies endow mice with new color vision
...d color vision tests that the genetic modification allows mice to see and distinguish among a broader spectrum of light waves. The experiments were designed to determine whether the brains of the genetically altered mice could efficiently process sensory information from the new photoreceptors in their eyes...Viral enzyme recruited in fight against ear infection
... breaks apart the infected bacterial cell wall and allows the new viruses to escape and infect additional cells. The success of the new treatment, which uses a phage enzyme to kill the bacteria that cause acute otitis media, suggests that the strategy could significantly reduce the incidence of the disea...Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu
... distributed information and data storage not only allows one to collect information more effectively, but also makes the data immediately available to researchers worldwide," said Kai Nan, director of CNICs Network Technology and Applications Research Laboratory. "The end result is a dynamic research commu...Researchers find best way to detect airborne pathogens
...any total cells there are in a given sample, which allows them to determine if any cells were lost by the sampling method (they had determined the exact counts in each bacteria sample prior to using each method.) For each sampling method, the researchers evaluated the number of total, viable and culturabl...Triplex assay used to assay duplex genomic DNA
...ive minutes. The highly sensitive diagnostic assay allows for the direct detection of base sequence in human...hington, has one moving part, the syringe pump. It allows samples to be automatically quantitated, a necessary step in the Genomic Assay because samples must ...ESA's Medspiration project branches out to support biodiversity
...aps as well as a map of dry lands. Medspiration allows users to open very high-resolution maps, down to two square kilometres, anywhere in the world, as illustrated by the map of Galapagos Island. In addition to aiding conservation studies, Medspiration has been delivering SST data of European seas since...New mathematical model to add rigor to studies of disease genetics and evolution
... interacting DNA motifs. The simulation software allows scientists to compare DNA sequences to find hotspot patterns in the population, which may be important to understanding disease or evolution. His coalescent simulation computer program, available free for download at Calabrese's Web site, showed t...Study: Chest compressions without mouth-to-mouth better for out-of-hospital cardiac arrest
...est in patients whose heart is in a condition that allows paramedics to shock it back into a normal rhythm with a defibrillator. Among these patients, the SOS-KANTO researchers found the percentage surviving with a favorable neurological outcome to be 19.4 percent if bystanders administered chest compressio...Researchers use poliovirus to destroy neuroblastoma tumors in mice
...earchers constructed a transgenic mouse model that allows growth of neuroblastoma cells and carries the huma... gene for CD155, which codes for the receptor that allows poliovirus to enter cells. The mice were then vaccinated against poliovirus. Since most humans are...Darwin's famous finches and Venter's marine microbes
...en directly from the environment. "Metagenomics allows us to sample the 99 percent of all bacteria that wont grow in the lab," explains Manning. "GOS opens a huge window into biological and genomic diversity and, within this diversity, to better understand many of the fundamentals of biology." he adds. ...CSHL shows correcting RNA splicing may help treat spinal muscular atrophy
...Krainer, Ph.D. RNA splicing antisense technology allows researchers to influence the ultimate structure and function of proteins. Proteins are synthesized from instructions coded in the DNA through a multi-step process that includes RNA splicing. Information stored in the DNA of genes is transcribed into...New agreement helps protect thousands of rice varieties -- the planet's most important food source
...k $200,000 from the Trust each year. The agreement allows for inflationary increases and will remain in force "indefinitely." The money will go toward, among other things, acquiring any rice varieties not currently in the repository and making sure the storage systems for long-term conservation are up to in...When your brain talks, your muscles don't always listen
...re based on sport, but my career in this field now allows me to address a much larger population that needs our knowledge," Knight said. "Exercise is still the means for improvement, and aging is a process that unites us all."......ecular fluorescence complementation (exBiFC) which allows simultaneous monitoring of individual proteins and...Brack-Werner and her team demonstrated that exBIFC allows visualization of interactions of Rev with itself and with Exportin1 and RISP in living cells. In add...Photodynamic therapy as alternative therapy for periodontal diseases may be beneficial
...ammation of the tissues surrounding the teeth, and allows tissues to repair faster." PDT may be an alternative to antibiotic treatment, which is becoming increasingly important as antibiotic resistance increases. PDT involves two stages; first, a light-sensitive drug is applied to the area. Second, a lig......rtin 2 and urocortin 3 are part of the system that allows the body to secrete and respond to insulin as appropriate, Vale says. "We have found both ligands and their receptor that play important roles in insulin secretion and sensitivity. But they are not the only regulators in this very complex process and...