Researchers discover inherited mutation for leukemia
... important to look for both genetic and epigenetic alterations when identifying problem genes," he says. CLL is the most common form of adult leukemia, with 15,300 new cases and 4,500 deaths from the disease expected this year in the United States. The leukemia is slightly more common in men than women, and t...New mouse model closely mimics human cancers
...c instability in the mouse cancer cells caused DNA alterations that in many cases were identical to such changes .... "We found a rather striking overlap of genetic alterations in the mouse and human cancers, which should greatly help us sort out genetic events that drive canc...New adult brain cells may be central to lifelong learning
...r a nerve impulse in the receiving neurons. Subtle alterations in receptor populations are the means by which the brain wires the preferred pathways in the process of learning and memory. The researchers also observed in the new adult neurons anatomical evidence of the same kind of formation of new connections...Study identifying alteration in gene associated with uterine cancer
...announced the discovery of previously unrecognized alterations in a gene called FGFR2 in a subset of endometrial cancers, the most common gynecologic cancer in the United States. The mutations in FGFR2 result in uncontrolled cell division, a hallmark of cancer. The findings, reported by TGen and research colleag...Caspase-14 protects our skin against UVB and dehydration
...hat go along with them. UV rays cause functional alterations in the most important components of our skin: the keratinocytes. In addition to causing normal sunburn and suppressing our immune responses, UVB damages the DNA in our cells, which can lead to cancer. In the last 15 years, the number of new cases of ...Effect on breast tumors of DNA alternations in 3 genes described
...mors. "It is well known that mutation in genes -- alterations in their sequence -- is one of the characteristics of tumors responsible for some of their disease properties," said Menghua Tao, Ph.D., research assistant professor of social and preventive medicine in the UB School of Public Health and Health Profe...Berkeley Lab Life Sciences division awarded NIH grants for fruit fly, nematode studies
...sed, or activating them in unusual contexts. These alterations may reveal the biological significance of the functional element. "We are making great strides in identifying functional elements in the human genome, but we still don't know much about their biological relevance," says Francis Collins, director o...'Might have been' key in evaluating behavior
.... These blood flow changes in the brain reflect alterations in the activity of nerve cells in the vicinity. In this case, they measured the brain's response to "what could have been acquired" and "what was acquired." This newly discovered "fictive learning" signal was measured, localized and precisely parsed ...University of Pittsburgh discovers genetic 'shut down' trigger in healthy immune cells
...filiated Magee-Womens Research Institute. "Harmful alterations in the code mutations can produce genetic disorders and play an important role in the development of cancer. Normal cells such as monocytes, lymphocytes and natural killer cells have many mechanisms to recognize and repair mutations, but a stop-cod...Scientists identify prion's infectious secret
...ly, the prions behavior could be altered by subtle alterations in the recognition elements amino acid sequence. While this prion is a laboratory construct not found in nature, these findings provide researchers with a new way to approach old questions, such as why some prion diseases can jump from one species...A rainbow of methods promises insights into biological processes and diseases
...PRING HARBOR, N.Y. (Tues., May 1, 2007) Physical alterations of DNA in chromosomes can cause serious diseases s...ble methods for marking molecules to identify gene alterations and metabolic shifts. The first method ( http://www.cshprotocols.org/cgi/content/full/2007/10/pdb....New understanding of schizophrenia could lead to new treatment approaches
...ts action. But until now it hadn't been shown that alterations in these genes lead to psychiatric disorders. Work... Program now demonstrate, for the first time, that alterations in NRG1-erbB signaling induce pathologic changes in the brain's white matter. They further show that...Scientists find major susceptibility genes for Crohn's disease
...hat genetic variation in the ATG16L1 gene leads to alterations in how the body uses autophagy and therefore may result in increased persistence of both cellular and bacterial components, leading to inappropriate immune activation and increased risk of Crohn's disease" adds Dr. Rioux. The findings reported in t...Scientists find new genes for Crohn's disease
...hat genetic variation in the ATG16L1 gene leads to alterations in how the body uses autophagy and therefore may result in increased persistence of [toxic] cellular and bacterial components. This may lead to an inappropriate immune activation and increased risk of Crohn's disease," says co-author Dr. Ramnik Xavie...Scientists find major susceptibility gene for Crohn's disease
...hat genetic variation in the ATG16L1 gene leads to alterations in how the body uses autophagy and therefore may result in increased persistence of both cellular and bacterial components, leading to inappropriate immune activation and increased risk of Crohn's disease," says co-author Dr. Hillary Steinhart, Head ...UT Metroplex institutions to collaborate on biomedical research
...changes in DNA expression can result in behavioral alterations mimicking debilitating diseases such as schizophrenia and autism spectrum disorder. Funded projects involving faculty from UT Southwestern and UT Dallas are: "Attachment of magnetic particles to kidney stone fragments for improved retrieval" ...Leading researchers honored for progress in cancer prevention, detection and treatment
...nnovative contributions to understanding molecular alterations in breast cancer. The AACR established this award in 1979 to recognize a young investigator for meritorious achievements in cancer research. Dr. Polyak's lecture, "Breast tumor progression: the role of stem cells and the microenvironment," will ta...Trends in bird observations reveal species' changing fortunes
...erns prompt Valiela and Martinetto to suggest that alterations in the northern part of the ranges of migrant birds dominate over the effects of changes further south, an effect that is so far unexplained. ...Healthy coastal wetlands would adapt to rising oceans
...mans -- including sea-level rise, sinking land and alterations to sand and silt supplies that anchor the wetland plants -- are "affecting coastal marshes worldwide," the scientists said. The research was funded by the National Science Foundation and the Andrew W. Mellon Foundation. The team's model, which wa......gh the researchers have identified a number of DNA alterations in the DARC gene, they did not pinpoint the spec...predict that changes in the amino acid sequence or alterations in regulatory regions of the DARC gene may lead to key functional changes. "There are interestin...