Tag: "alterations" at biology news
Links between DNA damage and breast cancer studied
... changes to DNA base and backbone structures. Such alterations
to the molecular structure can change or disrupt gene expression. The team identified a unique oxidation-induced lesion in the DNA of breast epithelium, myoepithelium and stroma and found that the highest concentrations of this lesion tended to oc...
JCI table of contents: August 1, 2006
.... They found that the high protein loss was due to alterations
in the composition of the glomerular basement membrane. In an accompanying commentary, Marilyn Farquhar from the University of California, San Diego discusses how the results of this study will change the prevailing view that another structure of t...
Pinning down a cancer threesome
...late as we age, and carcinomas are associated with alterations
in certain key genes, known as tumor suppressor genes and oncogenes. The overexpression of oncogenes disrupts complex cellular signaling pathways and leads to tumor development. However, most oncogenes also play a variety of essential roles in the no...
MicroRNA processing and cancer
...tep during microRNA biogenesis, which may underlie alterations
of microRNA expression in cancer. MicroRNAs (miRNA...an suppress miRNA production in cancer cells. "The alterations
in miRNA expression that are observed in cancer are dramatic. Our studies raise the possibility that...
New genetic findings add to understanding of OCD
...in cells. So, variations in the gene might lead to alterations
in that flow, perhaps putting a person at increased risk of developing OCD. The new findings are especially important not only because of the simultaneous discoveries reported in the papers, but also because of previous studies that show a functio...
$1.4 million grant helps professor see the light
...rugs also potently inhibit PDE6, causing temporary alterations
in vision. A better understanding of the differences between PDE5 and 6 will result in creating drugs that selectively target PDE5 but do not affect PDE6 or the visual process. While Cote does not foresee an immediate role for these drugs in combatin...
Researchers uncover genetic clues to a common form of age-related dementia
BETHESDA, Md. Researchers have found that genetic alterations
originally identified in people suffering from a r...a School of Medicine in Philadelphia reported that alterations
in the gene that codes for an enzyme called glucocerebrosidase (GBA) may contribute to the developme...
Jellyfish dominate fish in over-harvested Namibian waters
...clude slowed or attenuated fish-stock recovery and alterations
in the nature of carbon cycling. ...
Researchers get closer to preventing Alzheimer's disease
...e hippocampus. These results support the idea that alterations
in IDE might be causally related to beta-amyloid peptides accumulation, starting in the earliest stages of AD. ...
Cause of neuronal death in Down's syndrome, Alzheimer's disease could be surprisingly simple
...searchers concluded that "Our results suggest that alterations
of receptor isoform expression can affect neurotro...ignaling and consequently neuron survival." "Small alterations
in neurotrophin/Trk receptor activation like those seen in [the trisomic mouse model] may be directl...
New clues for treatment of liver cancer
...red makeup of the liver stem cells, and on genetic alterations
that occur spontaneously after they are transplant...ential to uncover the relevant spontaneous genetic alterations
and reveal the corresponding genes that, when altered, contribute to liver cancer. In one set of e...
Speeding discovery of the 'human cancer genome'
...enome" --a comprehensive collection of the genetic alterations
responsible for major cancers--is the strategic co...n the number of regions is to look for chromosomal alterations
found in both humans and in the complementary, or syntenic, regions of the mouse genome. "If you a...
Long-term changes in experience cause neurons to sprout new long-lasting connections
...ge changes in fluorescence that revealed dendritic alterations
present on the neurons. In this most recent experiment, Svoboda's team was looking to see if persistent changes in connectivity occurred after a long-term change in experience. They focused on the formation of new long-lasting spines that indicate ro...
New egg freezing technique offers hope to hundreds of women
...hat there are a number of very small but important alterations
to specific parts of numerous oocytes, which presu...ozen-thawed oocytes. "As far as the other possible alterations
are concerned, the reduction in amount and density of the cortical granules and the consequent harde...
Researchers attack tumor cells by exploiting dependency on sugar metabolism
...notype of the tumor cells. These data suggest that alterations
in glucose metabolism in cancer cells are linked with changes in mitochondrial physiology and that LDH-A plays a critical role in tumor growth. The researchers propose that inhibition of LDH-A may represent a rational and safe strategy for treatment ...
Activation of microRNA inhibits cancer gene in human cancer cells
...ned whether miRNAs can be controlled by epigenetic alterations
linked to chromatin remodeling. Cancer cells and normal cells were treated with chromatin-remodeling drugs to simultaneously inhibit DNA methylation and histone deacetylation. A subset of miRNAs was upregulated in the cancer cells but not the normal ...
Speeding the search for elusive chromosomal errors
...eam, allow more precise analysis of very small DNA alterations
throughout all of a patient's chromosomes. Gene C... in Genomic Diseases Conditions that originate in alterations
of chromosome architecture have been called "genomic diseases." The smallest of these structural def...
ADHD drug 'harmonizes' with body's dopamine system, gives hint to effect on children, adults
... direct comparison of presynaptic and postsynaptic alterations
in an age-matched patients group. ...
Beaver dams create healthy downstream ecosystems
...ns for the reduction in beaver population, such as alterations
in the flow along the Colorado River, similar hydrologic effects downstream likely affect river systems worldwide....
Genetically altered mice no longer like cocaine
...his colleagues raised laboratory mice with genetic alterations
in the gene that codes for the dopamine transporter. "By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the neurons," Gu said. The researchers tested cocaine...
1 2 3 4 5 6 7 8 9 10