Tag: "alterations" at biology news
Increasing norepinephrine stabilizes breathing patterns in a mouse model of Rett Syndrome
... to note that individuals with drastic respiratory alterations
can spontaneously display transient periods of normal breathing and that breathing can normalize during sleep. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure. At birth, the...
Low-level exercise delays heart failure, markedly extends lives, even with hypertension
...of the classic cellular and systemic physiological alterations
normally associated with the development of overt ...ity, the exercise regimen "prevented or suppressed alterations
in myosin heavy chain isoform expression, cardiac cell morphology, proteinuria, plasma ANP, and body...
Biotechnology's newest chemical tool
...ill not only help reveal the impact of biochemical alterations
to DNA, but could have far-reaching implications for DNA-based medical diagnosis and nanobiotechnology. Combining chemistry with biotechnology, Saulius Klimasauskas, a Howard Hughes Medical Institute (HHMI) international research scholar at the Ins...
Study of domesticated foxes reveals changes in gene expression as a basis for tame behavior
...an important mechanism for evolutionary behavioral alterations
that arise in the course of domestication....
New gene marker may identify need for intense AML therapy
...nts whose cancer cells show none of the chromosome alterations
that help doctors determine the probable prognosis... AML patients have cancer cells showing chromosome alterations
at the time of diagnosis. Doctors rely on these alterations
to help determine the best therapy for t...
Why children of parents with type 2 diabetes are at risk themselves
...o two recent studies, the authors did not find any alterations
in PGC-1a or PGC-1b or other downstream regulators of mitochondrial gene expression. These results provide new insights into the earliest defects that may be responsible for the pathogenesis of type 2 diabetes. Moreover, reduced mitochondrial conten...
Technique offers new view of dynamic biological landscape
...east have half-lives of ten minutes or so, but our alterations
destabilized them to have only a half-life of a couple of minutes. Consequently, they produce five- to ten-fold less protein," he said. In developing E-MAP, the researchers faced a significant hurdle: Even yeast's relatively modest 6,000 genes would...
Scientists crack code for motor neuron wiring
...ns. In a key set of experiments, Dasen showed that alterations
in Hox expression patterns in specific neurons res...lesion. "Or, it could be that injury causes subtle alterations
in the wiring of spinal circuits, and these alterations
may constrain the capacity for full recovery...
Forgotten by evolution?
...for heritable modifications of the DNA others than alterations
of the base sequence like DNA-methylation and changes of the chromatin). In the differentiation toward skeleton musculature, the scientists indeed saw characteristic features of the skeletal muscle cells. It never came, however, to the point that tru...
ECCO 13 - Chernobyl legacy sheds light on link between thyroid cancer and radiation exposure
... link between the patterns of molecular biological alterations
observed post-Chernobyl in thyroid cancer might actually be related to the age of the patients under study, rather than radioiodine exposure. Only one child out of the 52 studied had a specific gene mutation, known as BRAF, which is typically present...
Newly recognized gene mutation may reduce seeds, resurrect plants
...Another somewhat similar mutant Arabidopsis showed alterations
only in wax and seed development, but not in the other mutated RST1 traits. This was a major clue that changes in lipid synthesis were somehow altering seed development. Scientists already know that lipids play an important role in signaling developm...
U-M scientists say fused genes trigger the development of prostate cancer
...se of cancer-related deaths in men. "Studying gene alterations
in prostate cancer is difficult, and as a result there has never been a clear identification of recurrent, non-random genetic rearrangements," says Jacob Kagan, Ph.D., program director for the Cancer Biomarkers Research Group at the National Cancer I...
Modifications render carbon nanotubes nontoxic
...In both cases, the researchers identified specific alterations
that reduce toxicity. Cytotoxicity refers to toxic effects on individual cells. In cytotoxicological studies, identical cell cultures are exposed to various forms and concentrations of toxins. In order to compare the toxicity of different compounds, ...
Studies on human genome variation provide insight into disease
...e right places Geneticists rely on variation, or alterations
in DNA sequence, for disease-association studies. Hereditary traits such as heart disease, arthritis, and Alzheimer's can be assigned to specific genomic regions based on their association with DNA markers. The success of disease-association studies...
NIH awards nearly $30 million for research facilities improvement projects
...roups in this state." RFIP funding can be used for alterations
and renovations, additions to existing buildings, and completion of "shell" space, but do not support construction or land acquisition. FY 2005 Research Facilities Improvement Program Grants: Massachusetts General Hospital (Boston, Mass.) $1,279...
UT Southwestern researchers find alterations in brain's circuitry caused by cocaine
DALLAS Oct. 21, 2005 Cocaine causes specific alterations
in the brain's circuitry at a genetic level, including short-term changes that result in a high from the cocaine, as well as long-term changes seen in addiction, researchers from UT Southwestern Medical Center have found. Such findings suggest possib...
A new turn-on for genes
...sign of targeted treatments that can correct these alterations
will require a deep knowledge of the basic cellular mechanisms that regulate gene expression." The scientists studied a group of proteins known as histones, which form disk-like structures called nucleosomes when they are wrapped by genes. Under a...
NIH joined by advocacy groups to fund research on autism susceptibility genes
...peated (some many times over). Theseextensive gene alterations
may contribute to the range of Autism SpectrumDisorders. The Emory project seeks to explore forms of familial inheritance through theX chromosome - because more males than females are diagnosed with autism.Zwick will use a highly innovative technolo...
JCI table of contents November, 2005
...genes in the signature. Finally, they screened for alterations
of the E1A-induced genes in naturally occurring cancers. This led to the identification of a cancer-specific signature composed of 5 genes induced by E1A that are overexpressed in a large fraction of cancers, correlating with tumor progression and un...
Muscle of obese 'programmed' to amass fat, genetic study finds
...ansient environmental stress can trigger permanent alterations
in metabolic control. Thus, our findings could reflect an epigenetic phenomenon in which obesity-induced modifications in gene activity provoke irreversible perturbations in SCD1 gene regulation." "While these findings may be somewhat discouraging ne...
1 2 3 4 5 6 7 8 9 10