Pediatric ritalin use may affect developing brain, new study suggests
...ected by ADHD, and Ritalin, a stimulant similar to amphetamine and cocaine, remains one of the most prescribed drugs for the behavioral disorder. "The changes we saw in the brains of treated rats occurred in areas strongly linked to higher executive functioning, addiction and appetite, social relationships and...OHSU lab finds meth receptor that could lead to therapy
...be considered a real target of methamphetamine and amphetamine in rodents and probably humans, too." Grandy add...n the Grandy laboratory demonstrated that meth and amphetamine stimulate the production of an important second messenger known as cyclic adenosine monophosphate, o...News tips from the Journal of Neuroscience
...onsistent with Fos expression patterns after acute amphetamine stimulation. Although hurdles remain, such methods offer new possibilities for assays of gene transcription. 2. An RNA-Binding Protein and the Stability of AChE Transcripts Julie Deschênes-Furry, Kambiz Mousavi, Federico Bolognani, Rachael L...Researchers find not all drugs are equal in treating teen drivers with ADHD
...ed-release stimulant, rather than extended release amphetamine salts (se-AMPH ER). The findings, which reinforce the use of OROS MPH to improve driving performance in teens with ADHD, will appear in the Sept. issue of Pediatrics. "Car collisions are two to four times more likely to occur among teens with AD...News tips from The Journal of Neuroscience
...g stimulus. In the Adcyap1−/− mouse, amphetamine normalized PPI responses and diminished hyperlocomotive behavior. Although the dopamine receptor antagonist haloperidol had no effect on PPI, a 5-HT 1A receptor antagonist blocked the antihyperkinetic effect of amphetamine. There also was an ampheta...New mechanism found for neurodegenerative effects of amphetamines in mice
...d whose effects manifest and linger long after the amphetamine has left the body. "The question of whether amphetamines like ecstasy (MDMA) or methamphetamine (METH) cause neurodegeneration in humans is one of the most controversial areas in science today," says Professor Peter Wells of the Leslie Dan Faculty o...Grabbing addiction by the tail
...ues tested the peptide in rats that had been given amphetamine once every other day for 20 days. During this period, the animals displayed stereotypical behavior such as repeated sniffing, licking, and grooming, indicating a craving for the drug. Such behavior parallels the compulsive thought patterns that peopl...Amphetamine-related drugs ameliorate symptoms of Parkinson's
...ion to L-DOPA-related treatments, drugs related to amphetamine were effective in ameliorating muscle rigidity, tremor, and impaired movement in these mice. Most effective was methylenedioxymethamphetamine HCl (MDMA), commonly known as ecstasy. It has been shown that amphetamines can trigger release of neurotrans...Amphetamines reverse Parkinson's disease symptoms in mice
... treating mice lacking dopamine with high doses of amphetamine derivatives including methamphetamine and MDMA, o...rent therapy. "The locomotor stimulating effect of amphetamine and its derivatives are classically thought to result from a massive flood of dopamine," said Sotnik......ations and delusions experienced in schizophrenia, amphetamine drug abuse or Alzheimer's disease. In drug abuse, the reaction is temporary; in schizophrenia, it recurs. "This research brings together two worlds: the psychosis of drug abuse and schizophrenia," says Seeman. "There's a common denominator based on ...