Tag: "amyloid" at biology news
Anti-cholesterol drug treats Alzheimer's disease in mice
...l drastically reduces the levels of brain-clogging amyloid
plaque in mice engineered to have a human form of the amyloid
protein. According to Dora Kovacs and her colleagues, the findings suggest that such inhibiting drug...
Trojan-horse therapy blocks buildup of Alzheimer's plaque
... in culture by drastically reducing the neurotoxic amyloid
protein aggregates that are critical to the develo...Alzheimer's disease develop through the buildup of amyloid
protein chains from individual units called A peptide. "There have been many attempts by pharmaceuti...
Research uncovers role of Apolipoprotein E in Alzheimer's disease
...tein E (ApoE) contributes to both the formation of amyloid
brain lesions and the memory loss associated with ...protein ApoE can speed the buildup in the brain of amyloid
plaques, the major pathological hallmark of Alzheimer's disease. These deposits of plaques are compo...
A new species of amyloid peptide
...cientists have identified a new, longer species of amyloid
β-peptide that has the potential to be a new ...atures of Alzheimer's disease is the deposition of amyloid
β-peptides in the brain. These amyloid
β-peptides are derived from a large amyloid
Findings show how toxic proteins rob Alzheimer's patients of memory
... be reversible. Although both are a form of amyloid
beta, ADDLs and their properties differ significantly from the amyloid
fibrils (known as plaques) that are a diagnostic hallmark of Alzheimer's. ADDLs found in human brain...
Fewer calories may slow Alzheimer's
...id. Made up of proteins and polysaccharides, amyloid
plaques aredeposited in the brain during Alzheimer's disease. Specifically,plaques accumulate in the hippocampus and frontal cortex ofAlzheimer's sufferers - areas responsible for memory. In the diet-restricted mice, both the amount and size of...
Gene vaccine for Alzheimer's disease shows promising results
...lating the immune systems of mice to fight against amyloid
proteins that cause the devastating plaques that a...ms of mice to potentially fight off plaque-causing amyloid
protein in the brain. Their findings appear in today's issue of the Archives of Neurology . "Pr...
Healthy cleavage: How statins protect against Alzheimer disease
...heimer disease is characterized by accumulation of amyloid
deposits in the brain. These deposits are composed...e, a protein fragment that is cleaved off from the amyloid
precursor protein APP. APP can be cleaved in two different ways. Amyloidogenic ("amyloid generating"...
Reduced calorie and carbohydrate diet slows progression of Alzheimer's disease in mouse model
...ineered to developthe disease. The diet eliminated amyloid
plaque development, which isthe underlying patholo...d peptides in the brain, resulting in formation of amyloid
plaques which are known to be the fundamental problem in Alzheimer' disease. Of the mice fed ad-libi...
Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...antibody for a key component of brain plaques, the amyloid
beta (Abeta) peptide. In areas of the brain where .... One, utilized by scientists at Eli Lilly, causes amyloid
plaques to build up, creating the Alzheimer's-like condition. The second, developed by scientists at...
Neuronal 'traffic jam' marks early Alzheimer's disease
... that underlies Alzheimer's pathology, called beta amyloid
precursor protein (beta-APP), triggers defects in ...of beta-APP is cleaved to form an aberrant form of amyloid
beta (A-beta) peptide that makes up the plaques that surround the neurons of people with Alzheimer's...
UCI researchers identify trigger for onset of Alzheimer's, aiding search for new therapies
...earchers have studied the association between beta amyloid
and memory, the UCI research team is the first to identify that early beta amyloid
accumulation within neurons is the trigger for the onset of memory decline in Alzheimer's. "This fi...
MGH study identifies potential Alzheimer's risk gene
...ound in four genes. Three of these involving the amyloid
precursor, presenilin 1 and presenilin 2 proteins ...on of A-beta," the protein that accumulates in the amyloid
plaques found in the brains of Alzheimer's patients. Tanzi is a professor of Neurology at HMS. The...
Enriched environment delays onset of Alzheimer's in mice
...ttings also had more of an enzyme that breaks down amyloid
as well as increased activity of several genes inv...e enriched environment had a dramatic reduction of amyloid
deposits in their brains, including less than half the volume of amyloid
deposits in the hippocampus...
Nobel laureates to open ASBMB annual meeting in San Diego
...lipid biosynthesis. Pathologically, it creates the amyloid
peptides of Alzheimer's disease. The Goldstein and Brown laboratory uncovered RIP through study of SREBPs, transcription factors that regulate the synthesis and uptake of cholesterol and fatty acids in animal cells. SREBPs are synthesized as transme...
Busy brains may stave off Alzheimer's signs
...urnished cages had the most dramatic reductions in amyloid
peptides and deposits. At least among this small g...e appears to play a significant role in modulating amyloid
deposition," Sisodia and colleagues write. The researchers caution, however, that it will take more ...
Fish oil holds promise in Alzheimer's fight
...-the high-DHA group had 70-percent less buildup of amyloid
protein in the brain. This sticky protein makes up the plaques, or patches, that are a hallmark of Alzheimer's. A similar study by Cole's group published in Neuron last fall showed that DHA protected against damage to the "synaptic" areas where bra...
Fibril shape is the basis of prion strains and cross-species prion infection
...otein, which aggregate into fibrous tangles called amyloid
fibrils and cause fatal wasting of brain tissue. T...rions were brought into contact with hamster prion amyloid
fibrils, a new strain of mouse fibrils emerged with the ability to infect hamsters but not humans. T...
Why do amyloid diseases strike different tissues?
...oscopic fibrils, which then cluster to form larger amyloid
plaques that deposit in peripheral nerves, organs,...tissues like the brain are more susceptible to the amyloid
plaques because they are specifically targeted by misfolded TTR proteins, but rather because cells t...
JBC study shows that bigger isn't necessarily better for amyloid proteins
...sputes the popular belief that the long, insoluble amyloid
fibrils found in amyloid-related diseases are what causes neurotoxicity. By comparing amyloid
protein aggregates of different lengths, the researchers have shown that it is actually the smaller,...
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