NHGRI seeks next generation of sequencing technologies
... develop the next generation of DNA sequencing and analysis technologies. "These projects span an impressive s..., commercial availability of reagents and existing analysis software, this group will push Sanger-based sequencing toward its performance limit in a completely ...Using fruitflies to examine alcohol tolerance
...l genetic tools that enable the identification and analysis of genes. Additionally, flies can be grown for experiments relatively rapidly and inexpensively." For this study, researchers exposed flies to either a single intoxicating dose of alcohol (rapid tolerance), or to a low concentration of alcohol cont...Purdue chemists give an old laboratory 'bloodhound' a sharper nose
... the time and effort needed to prepare samples for analysis have made it difficult to use them in the field. W...This backpack-size device will be useful for field analysis of chemicals, filling a need in airport baggage security and drug detection," said Wiseman, a gradua...Biological importance of basal activity of appetite suppressor
...at it is required for this basal activity. Further analysis proved that this domain func-tions as an intermolecular self-activating ligand that does not mimic manner in which a-MHC activates MC4R. The work here suggests that in devising therapies for obesity that target MC4R, designing a molecule that provide...Peakadilly nv biopharmaceutical firm created
...t into the origin and progression of diseases. The analysis of the effect of a drug on the proteome enables researchers to understand which protein(s) the drug acts upon. Until recently, however, there was no efficient way to study the proteome systematically. Pioneering research under the direction of Jol Va...Medical geneticists elected to Institute of Medicine
... is a national resource for independently informed analysis and recommendations on issues related to human health. With their election, members make a commitment to devote a significant amount of time as volunteers for IOM committees, which conduct a broad range of studies on health policy issues. "We are t...Common gout drug shown to reduce risk from colorectal cancer
...f Michigan, Ann Arbor. Results were based on the analysis of 1,781 patients from Northern Israel who were prescribed allopurinol and enrolled in the Molecular Epidemiology of Colorectal Cancer (MECC) Study group between 1998 and 2004. Use of the drug was measured by a structured, in-person interview, with r...Men with prostate permalignant lesions have increased likelyhood of invasive prostate cancer
...being diagnosed with prostate cancer. A sub-set analysis of the placebo patients in a year long, chemopreventive toremifene study, which was also presented at the AACR meeting here, confirmed that men with high-grade PIN have an increased, cumulative risk of being diagnosed with prostate cancer after one y...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
... Next, the team used a technique called DNA array analysis to identify which genes in the CD4+ T cells are activated in cells that develop into regulatory T cells. The investigators found that the Lag-3 gene was "expressed" (being used by the cell to make protein) to a much greater extent in regulatory T cel...Gene-altered mouse is model for rare autoimmune syndrome
...response. Importantly, said Zhuang, genetic analysis can be further applied to this animal model. For example, the defect in Id3 may cause different effects in different strains of mice with other genetic deficiencies -- offering even further opportunity for understanding the intricacies of immune sys...Incentives for US farmers reduce water waste
...by shortages of water, three facts stand out in an analysis by Cornell University ecologists: Less than 1 perc... led nine student ecologists through an exhaustive analysis of research conducted at other institutions and government agencies. "We learned, for example, that ...Citizen environmental monitoring in Appalachia
...) is the repeated collection of, and in some cases analysis of, environmental data by local volunteers. Ecological parameters measured by volunteers should be selected to answer questions of interest to the community and can be used for a variety of purposes including setting background levels, establishing e...International human genome sequencing consortium describes finished human genome sequence
...00 to 35,000 genes, which surprised many. This new analysis reduces that number even further and provides us w...hat are predicted to be protein-coding genes. "The analysis found that some of the earlier gene models were erroneous due to defects in the unfinished, draft se...New genomic method can identify disease-causing genes
...roach, another innovation in computational genetic analysis from Roche scientists, promises to accelerate mark...range of human diseases and toward pharmacogenetic analysis of how various drugs that are used commonly to treat disease work in humans. The paper, entitled...New method studies living bacterial cells
...tal. The results indicated that X-ray fluorescence analysis had distinguished living bacterial cells from dead cells for the first time. The analysis also showed that a bone-like mineral deposit had formed around the surface of the adhered cells. Thi...Cars, not crops, should be chief targets in reducing greenhouse gases
...ording to two Duke University ecologists. In an analysis to be published the week of Oct. 25, 2004, in the ...e chose a 10 percent reduction as the basis of our analysis to place it in the realm of possibility." Their calculations showed that converting all U.S...New center to map DNA of key lab mice
... begin translating research findings to population analysis and to toxicology testing. These studies will also influence the development of curative treatment and regulatory decisions. "Before genetic mapping, we were able to expose a mouse to environmental toxins and see 'if' a disease developed, but with ge...Emory study details dolphin brain evolution for the first time
...y gone unanswered. In the first-ever comprehensive analysis of its kind, a new Emory University study maps how brain size changed in dolphins and their relatives the past 47 million years, and helps to provide some answers to how the species evolved in relation to humans. The study, which will appear in the ...Stimulating nerve cells with laser precision
...ot" and other inaccurate data in the recording and analysis of the procedure, making it tedious and difficult to locate the exact nerve. Optics, on the other hand, can deliver laser precision by stimulating only the nerve cell of interest. The idea of optical stimulation started as the sc...Munching microbes could cleanse arsenic-contaminated groundwater
...c which generally requires a sensitive laboratory analysis testing for sulfate is simple and straightforward," Bethke said. "If all waters containing sulfate are safe, as in our dataset, then measuring sulfate level would be an easy but reliable field test to identify safe drinking water from unsafe." Addi...