Tag: "androgen" at biology news
New findings may redirect strategies for treatment of prostate cancer
...surprising new information about modulation of the androgen
receptor (AR), a key determinant of prostate cance... metastatic disease and receive treatment to block androgen
production and the AR itself. Unfortunately, although this treatment may work for some time, the dis...
Army-funded effort examines androgen's role in bone loss
... effort examining the role of the male sex hormone androgen
in bone formation has piqued the interest of the U...ding of the molecular and cellular events by which androgen
influences the skeleton. "It turns out that one of the most common injuries sustained in basic tr...
Seeking better cancer treatments
...RDES carried out essential research with the human androgen
receptor to understand the mechanism of the mode of action of androgens. The human androgen
receptor (hAR) binds the male sex steroids and regulates genes for male differentiation and developm...
Component of plastic stimulates growth of certain prostate cancer cells
...men who develop BPA-susceptible mutations in their androgen
receptor genes during the course of prostate cance...ting testosterone synthesis. Patients with mutated androgen
receptors may not respond to this therapy and according to this new study, exposure to BPA among the...
Study provides insights on why some prostate cancer becomes resistant to hormone withdrawl therapy
...und that certain mutations in a protein called the androgen
receptor cause advanced and invasive prostate cancer when put into otherwise healthy mice. The androgen
receptor's normal function is to control growth of the prostate gland in response to cues from male ...
Defining male and female
...s when a mutation of the gene that encodes for the androgen
receptor results in resistance to androgen's masculinizing effects during development. Depending upon the timing of exposure to androgens in the uterus, a host of other conditions may result in ambiguous genitalia. Through his clinical work with some...
A more accurate screening test for prostate cancer?
... with other genitourinary diseases. Men receiving androgen
deprivation therapy (an indication they had aggressive prostate cancer) were 12 times more likely than the healthy controls to have elevated thymosin 15. Notably, nearly half of cancer patients whose PSA levels were considered normal tested posi...
Gene associated with breast cancer may play major role in prostate cancer recurrence
...ence of prostate cancer is the reactivation of the androgen
receptor, which normally requires the presence of androgen, and this reactivation of the androgen
receptor underlies tumor progression of prostate cancer despite hormonal therapy. Exactly how this o...
Tendency to hair loss inherited from the mother
...st contribution was suspected lay the gene for the androgen
receptor. "One variant of this gene was found amon...of hair when over 60," Professor Nthen says. More androgen
receptors in the scalp Probably the genetic variant results in more androgen
receptors in the scalp...
A novel model to pinpoint human androgen receptor targets developed
A novel computational model to pinpoint androgen
receptor targets within the human genome was recen...Maryland, USA ( www.cpdr.org ). Identification of androgen
receptor target sites is crucial for the understanding of prostate cancer that is the second leading...
New treatment options for patients with prostate cancer
...apy. Data was presented on a new compound to treat androgen
independent prostate cancer. An Australasian study reviewed the benefits of administering maximal androgen
deprivation treatment before radiotherapy. The Dutch study, a multicentre randomised Phase III trial...
Recycled or revamped therapeutics find novel anti-cancer applications
...ternative to hormonal ablation therapy." Long-term androgen
suppression therapy (more than one year) can lead to significant side effects, including bone density loss, anemia, breast enlargement, hot flashes, impaired memory, and impotence in some patients, especially among elderly men. "Existing hormone abla...
Pesticide combinations imperil frogs, probably contribute to amphibian decline
...e frogs by blocking the action of the male steroid androgen
and feminizes them by stimulating the production o...ons in frogs by administering estrogen or blocking androgen
at the proper time of development. "One week of exposure at the critical time is all that's required...
Inflammatory reaction drives hormone resistance in cancer, study suggests
...to particular cancer drugs." Androgens, acting via androgen
receptors, are essential for normal growth and fun...d in the progression of prostate cancer. Selective androgen
receptor modulators (SARMs) --drugs intended to inhibit the activity of androgen
Pepper component hot enough to trigger suicide in prostate cancer cells
...wth of prostate cancer cells through regulation of androgen
receptors, the steroid activated proteins that con...ate, called G0/G1. Prostate cancer cells that are androgen
independent reacted to capsaicin in a similar manner.Capsaicin reduced the amount of androgen
Understanding the life of C. elegans
...speculates that this may resemble how estrogen and androgen
hormones similarly govern human maturation....
Like mother, like cubs
...udy shows that alpha females have higher levels of androgen
during the final stages of pregnancy than lower-ra... Young males exposed to higher levels of prenatal androgen
exhibit mounting behaviors more often than the males born to lower-ranking females. In other words, ...
Hyena mothers give their cubs a helpful dose of hormones
...ith her colleagues, spent almost 10 years sampling androgen
levels from free-ranging hyenas in Kenya. Androgen...vior. The team found that alpha females had higher androgen
levels late in pregnancy when compared to the subordinate, pregnant females in the pack. Consequentl...
Hormonal male contraception reversible after few months for all men
... women, sperm production can be fully inhibited by androgen
or androgen-progestagen treatment combinations in ...hieved. Currently, a large phase III study with an androgen
treatment and a large, multicentre phase II study of androgen-progestagen combinations are being com...
Novel enzyme offers new look at male hormone regulation
...rotein plays a role in gene activation mediated by androgen
receptor, a protein that responds to androgen
hormones. In this regard, the novel protein may figure in the development of prostate cancer. Androg...