Protein in urine may warn of preeclampsia risk in pregnant women
...chers have discovered that diminished levels of an angiogenic protein associated with preeclampsia can be detect...clampsia was caused by an imbalance of circulating angiogenic growth factor molecules, which enable the growth of small blood vessels. "In a normal pregnancy, the...Study shows naturally occurring proteins protect against rapid tumor growth
... of healthy individuals Kalluri hypothesized that angiogenic inhibitor molecules were acting as tumor suppressors to control the rate of cancer progression. "For several decades now, autopsies have shown that many people [between ages 40 and 50] who have died of trauma [i.e. automobile accidents, suicide] hav...JCI table of contents March 1, 2005
...iversity, delve into the mechanisms underlying the angiogenic effects of BDNF in adult blood vessels. The resear...diseases of vascular insufficiency. The selective angiogenic activity of BDNF compared to other growth factors, could lead to the development of organ specific a...Boosting blood vessels with BDNF
...iversity, delve into the mechanisms underlying the angiogenic effects of BDNF in adult blood vessels. The resear...diseases of vascular insufficiency. The selective angiogenic activity of BDNF compared to other growth factors, could lead to the development of organ specific a...Gene mutation protecting against malaria linked to prostate cancer incidence in African-American men
...occurs when tumor cells release small compounds or angiogenic factors that cause existing blood vessels to grow into the tumor. One class of angiogenic factors released by prostate tumors are chemokines, small proteins that promote angiogenesis by bind...JCI table of contents May 2, 2005
...s have increased vascular remodeling and increased angiogenic activity. The latter was due to elevated levels of proteins called chemokines, namely CXC chemokines. Blocking CXC chemokine action by inhibiting receptor interactions was beneficial in mice and reduced BOS. In an accompanying commentary, Ivor Do...MIT tissue engineers implant viable, vascularized 3D muscles
...ays. "The differentiated fibroblasts expressed the angiogenic growth factor, VEGF, which further stimulated vessel growth." The constructs measured 5mm by 5mm by 1mm. For implantation in living animals, the lab used immunodeficient mice and rats that would not reject the human-derived endothelial cells. At the ...Does gene therapy work? Nuclear medicine may provide the answers
...ted a beneficial effect of Cyr61--a cysteine-rich, angiogenic inducer protein--in rabbits submitted to ischemic limb disease. However, no data have been available on using Cyr61 in vivo for fighting chronic myocardial ischemia (insufficient blood flow and oxygen to the heart muscle). "Cyr61 gene transfer appear...Unique interplay between tumor and blood vessel cells promotes angiogenesis and tumor growth
...ulated with a known growth factor. They found that angiogenic factors stimulated the mitogen-activated protein kinase (MAPK) pathway to induce the Notch ligand Jagged1 in head and neck squamous cell carcinoma cells. Jagged1 triggered Notch activation in neighboring blood vessel cells and promoted formation of n...New lead reported in tumor angiogenesis
...t. "Still unanswered was exactly how HGF sets the angiogenic process in motion," said Dr. Qinghua Zeng, lead author on the paper and a researcher at the University of Michigan, noting that HGF also has a pro-angiogenic effect in other tumor types. "We needed to connect the molecular dots." Zeng and his collea...Studies find possible drug targets for improving vascular health
...lary formation and vascular leakage induced by the angiogenic factor vascular endothelial growth factor (VEGF) requires Akt1. VEGF is produced by ischemic tissue, as well as tumor cells, to stimulate the formation of new blood vessels. The data also suggest that inhibition of Akt1 signaling may be an effective ...Other highlights in the September 7 JNCI
...l-cell lung cancer (NSCLC), appears to inhibit the angiogenic activities of NSCLC and head and neck squamous cel...cells. They found that SCH66336 appears to inhibit angiogenic activity of NSCLC and HNSCC cells by inhibiting the interaction between hypoxia-inducible factor 1 a...A novel mechanism of action for anti-tumor agent, CA4P
... months. Therefore, identification of unrecognized angiogenic pathways that selectively support tumor neo-vessel assembly will increase the efficacy of anti-angiogenic or anti-vascular therapy. The prototypical vascular targeting agent combretastatin A4 phosphate (CA4P) exerts its anti-angiogenic effect by tar...JCI table of contents November, 2005
... months. Therefore, identification of unrecognized angiogenic pathways that selectively support tumor neo-vessel assembly will increase the efficacy of anti-angiogenic or anti-vascular therapy. The prototypical vascular targeting agent combretastatin A4 phosphate (CA4P) exerts its anti-angiogenic effect by tar...Group proves it's possible to grow new lung alveoli by growing new blood vessels
...ment of the lung, and that angiopoeitin-1, another angiogenic growth factor is crucial for blood vessel maturation, the team attached the proteins to an adenovirus and administered it through an aerosol directly into the lungs. In effect, the virus carried the protein to the heart of millions of lung cells. Onc...The American Association for Cancer Research provides support for promising cancer scientists
...s a potentially novel biomarker and/or therapeutic angiogenic target for renal cell cancer AACR-MedImmune Fellowship for Research on Biologics-Based Therapies for Cancer Recipient: Robert R. Jenq, M.D., Memorial Sloan-Kettering Cancer Center, New York, N.Y.Project: Augmentation of immune responses to melano...Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
...lts suggest that SCF is a potent glioma-associated angiogenic factor that plays a prominent role in pathological angiogenesis both through direct tumor cell expression of SCF and by normal neurons that are damaged by the growing tumor. The researchers point out that the clinical significance of these findings e...Schepens scientists are first to discover angiogenesis switch inside blood vessel cells
... delicate retinal tissues when uncontrolled. The angiogenic process is triggered by what the body perceives as a need for additional blood flow. In the case of disease, it is a mistaken need. In response, the body sends growth factors (such as VEGF) to blood vessels in the "needy area" to bind to receptors o...Researchers identify protein associated with severe preeclampsia
...luble endoglin are inhibiting the functions of two angiogenic growth factors vascular endothelial growth factor [VEGF] and transforming growth factor beta," explains Karumanchi. "The diminished signaling of these growth factors in the vasculature adversely affects the health of the mother's small blood vessels......gnificantly over-expressed gene was cysteine-rich, angiogenic inducer 61 (Cyr61), well-established for its role in the formation of new blood vessels. "Our findings provide the first evidence that laeverin is abundantly expressed in synovial tissue," notes the study's leading author, Joseph Holoshitz, M.D. "...