Immune system 'escape hatch' gives cancer cells traction
...igate the binding receptors of MDCSs and different anticancer drugs for their ability to lower levels of MDSCs and to explore the role of MDSCs in suppressing the immune response to stress, bacterial and viral infections, organ transplantation and autoimmune diseases. Their goal, researchers say, is to find so...A compound from olive-pomace oil gets 80 percent slowing down of HIV spread
...acid is a pentacyclic terpene with antioxidant and anticancer effects found in wax from olive skin, alongside oleanolic acid. The effects of this compound in the fight against AIDS are simultaneously being studied in the UGR and in Hospital Carlos III in Madrid by a team headed by Prof. Vallejo Njera. Masli...American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
...opment of more generally applicable platinum-based anticancer drugs. These include analogues of the widely used and extremely potent drugs cisplatin, carboplatin, and oxaliplatin. The report is scheduled for the July 11 issue of the Journal of the American Chemical Society , a weekly publication. The Massac...Other highlights in JNCI, June 12
...d before the further development of deguelin as an anticancer therapeutic agent, the authors write. Contact: Laura Sussman, press office, M. D. Anderson Cancer Center, 713-745-2457, lsussman@mdanderson.org Also in the June 12 JNCI: http://www.eurekalert.org/emb_releases/2007-06/jotn-ab060707.php ht...Sensitivity to diverse range of chemotherapeutic drugs linked to common pathway
...siveness of cancer cells to drugs commonly used as anticancer therapeutics. The research, published in the June issue of the journal Cancer Cell, published by Cell Press, identifies individual genes that are associated with resistance to chemotherapeutic drugs and sets the stage for future studies that may sign...Tumor vessels identified by unique molecular markers
...or development of more selective vascular-targeted anticancer therapeutics. A major strategy for destroying cancer cells has been to disrupt the growing blood vessels that support tumor growth. However, current vascular-targeted therapies may also damage normal growing blood vessels. This is a concern because...ChemGenex reports successful personalized dosing of Quinamed at ASCO
...able side effects, and (iii) there was evidence of anticancer activity in several solid tumor types. Dr. John ...ects of therapy. We are encouraged by the signs of anticancer activity across a range of tumor types in patients who had failed multiple prior therapies, and loo...Manchester researcher wins Libyan award
...studies deals with the synthesis and evaluation of anticancer drugs. There are many clinically approved anticancer drugs, and new anticancer drugs in various stages of preclinical and clinical development. These dru...New designer lipid-like peptide with lipid nanostructures for drug delivery systems
...f biological active materials. Currently, many anticancer drugs are difficult to deliver to patients due to their difficulty to be soluble in water. This is a systematic study to combine with lipid molecules, Shuguang Zhang of MIT, a co-author said, people have been curious about if these similar molecules...Combining NSAIDs with chemotherapy, radiation may improve cancer treatment
...I studies show that the NSAID celecoxib has potent anticancer activity, which is associated with the drug's abil...studies have systematically evaluated the relative anticancer activity of different NSAIDS. In one study, published in the April 5 online issue of Molecular Car...Other highlights in the May 16 JNCI
...sibility that FLIP is a potential target for novel anticancer therapies," the authors write. Contact: Jane Finlayson, senior public affairs advisor, Princess Margaret Hospital, (416) 946-4501 ext. 2846, Jane.Finlayson@uhn.on.ca...Einstein's Dr. Vern Schramm elected to the National Academy of Sciences
...as designed, known as Immucillin-H, is a promising anticancer agent for treating T-cell malignancies. It is currently in a pivotal phase IIb clinical trial (specifically targeted to study efficacy) at sites in the U.S., eastern and western Europe, and South America. Another transition-state inhibitor develop...News tips from the Journal of Biological Chemistry
...fruits, vegetables, and red wine, is known for its anticancer properties, but the details of how it works at the... cells. These results could be used to develop new anticancer drugs, the scientists concluded. Article: Cyanidin-3-Rutinoside, a Natural Polyphenol Antioxidant...Knocking out survival protein could aid leukemia treatment
...bundance of the protein are also more resistant to anticancer drugs such as rituximab, which has revolutionized the treatment of certain chronic and acute leukemias. The study by researchers at the Ohio State University Comprehensive Cancer Center is published online in the journal Clinical Cancer Research. ...News tips from the Journal of Biological Chemistry
...th the anthrax bacterium. This compound is a known anticancer agent with well-studied pharmacological properties...elps synthesize CTP, was inhibited by acivicin, an anticancer drug previously tested in humans and animals but now abandoned. The scientists tested the action of ...Popular herbal supplement hinders the growth of pancreatic cancer cells
... "Our results demonstrate that triphala has strong anticancer properties given its ability to induce apoptosis in pancreatic cancer cells without damaging normal pancreatic cells," said Dr. Srivastava. "With follow-up studies, we hope to demonstrate its potential use as a novel agent for the prevention and trea...Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
...otential to be effective in combination with other anticancer agents," the authors concluded. Vladimir Khazak, Ph.D., now director of biology at NexusPharma, Inc., in Langhorne, Pa., and formerly a postdoctoral associate in the Fox Chase laboratory of molecular biologist Erica A. Golemis, Ph.D., presented the r...... study, and they also may be potential targets for anticancer medicines, he adds. ...Light-activated therapy targets DNA components
... The groups previous work included delivering the anticancer drug cisplatin and improved compounds to a disease site. In the process, the coupling of the drugs to the designed molecule increased water solubility. The improved selectivity along with photoinitiation reduce damage to healthy tissue. The paper, ...Blood's clotting cells harbor 'ticking time bombs,' finding may help extend blood supply
...d by the researchers was a BH3 mimetic, a class of anticancer therapy that is now under development, Huang explained. The drugs work by targeting Bcl-xL and related prosurvival genes in tumor cells. Bcl-xLs newfound role reveals that the new cancer drugs will likely lead to a decline in platelet numbers. Howe...