JCI table of contents -- March 22, 2007
...emic cells find protection in the bone marrow from anticancer drug As part of their therapeutic regimen, individuals with acute lymphoblastic leukemia (ALL) are treated with asparaginase a protein that breaks down the amino acid asparagine. ALL cells are sensitive to a lack of asparagine in their environmen...New drugs for cancer therapy at international conference in Amsterdam
...I) that have not been released before. Targeted anticancer agents are the subject of extensive research and development activities worldwide, often conducted in joint projects of academic research institutes and pharmaceutical companies. These drugs are characterized by the fact that they have a well-defined...Therapeutic peptide frees the protein p73 to kill tumor cells
... tumor cell death, making it an obvious target for anticancer therapeutics. However, this therapeutic approach i...than p53 for the development of broadly applicable anticancer therapeutics. In the study, which appears online on March 8 in advance of publication in the April...JCI table of contents -- March 8, 2006
... tumor cell death, making it an obvious target for anticancer therapeutics. However, this therapeutic approach i...than p53 for the development of broadly applicable anticancer therapeutics. In the study, which appears online on March 8 in advance of publication in the April...ACS News Service Weekly PressPac -- Feb. 21, 2007
..." into therapeutic cosmetics Toward powerful new anticancer drugs with new ways of targeting tumors A new ta...CLE #4 FOR IMMEDIATE RELEASE Toward powerful new anticancer drugs with new ways of targeting tumors Journal of the American Chemical Society The search for n......ounds that regulate polycomb could result in novel anticancer drugs that shrink malignant tissue, and prevent cancer recurrence, a common problem with most chemotherapies. That tumours and stem cells have much in common has been known for many years. Both self-renew and both spawn many different types of cel...HIV protein enlisted to help kill cancer cells
...laboration began between their labs to exploit the anticancer potential of TAT-Bim. "Unlike most healthy cells, ...Ph.D. professor of radiology, they are linking the anticancer proteins to tracer molecules that selectively bind to cancer cells. "Dr. Mach designed tracers to vi...Oxidative stress stimulates p38 MAPK-mediated tumor suppression
...identifies possible targets for development of new anticancer therapeutics. The MAPK p38-alpha is a signaling protein that plays a critical role in coordinating cellular responses to stress, including oxidative stress that is characterized by the accumulation of increased levels of reactive oxygen species (R...Discovery could lead to better control of hemorrhagic fever viruses
...nti-TfR1 antibodies have already been developed as anticancer therapeutics (cancer cells are also high in TfR1), and some have already been through clinical trials. Choe's lab will test these antibodies, hoping to find one that inhibits virus entry without compromising TfR1's essential function in cellular iron...ACS News Service Weekly PressPac -- January 24, 2007
...on: Toward development of an "eggshell-and-yolk" anticancer nanomedicine New method for detecting fake drugs...EASE Toward development of an "eggshell-and-yolk" anticancer nanomedicine Journal of the American Chemical Society Scientists in Hong Kong are reporting synth...Chemicals in brown algae may protect against skin cancer
...own that BAPs are strong antioxidants and may have anticancer properties. For this study, Stoner and his collaborators used a strain of hairless mice that are particularly susceptible to UVB-induced skin cancer. Nine experimental groups were used, each with 20 mice. In two groups, BAPs were applied to the...Researchers urge monitoring of bone health during chemotherapy
...ergo more intensive chemotherapy regimens in which anticancer agents are given at more frequent intervals. Studies have suggested these dose-dense therapies could prolong survival in women with breast cancer. "We are not at all advocating ending G-CSF use," says Weilbaecher, an oncologist with the Siteman Canc...Other highlights in the January 3 JNCI
...ol study. Laboratory tests of statins have found anticancer effects on colon cancer cells. One case-control study of people found that use of statins for at least 5 years reduced the risk of colorectal cancer by 50 percent. To further understand the possible association between statin use and colorectal cance...Epigenetic drugs, promising for breast cancer treatment
...rated, they would not only be added to the current anticancer armamentarium, but they will surely be affordable ...ow and middle income countries, who find the newer anticancer agents prohibitively expensive. Dr Dueas-Gonzalez's group has recently completed a couple of single ...News tips from ACS Chemical Biology
...e system. Cryptophycins are important potential anticancer agents produced by blue-green algae. Magarvey & Sh...he generation of novel cryptophycins with improved anticancer activity. The phosphoinositide 3-phosphatase PTEN is known to play a role in the regulation of i...Novel EGFR ectodomain mutations in glioblastoma
... often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblasto...A fisheye view of the deadliest breast cancer
...rs make high-resolution 3D images of two potential anticancer compounds at work: a vascular endothelial growth ...tumor behavior and as a rapid screening system for anticancer drugs. In the race against aggressive breast cancers, Stoletov and colleagues see their xenografted,...JCI table of contents: December 7, 2006
...he sensitivity of the cells to radiation and other anticancer drugs, both of which are treatments given to patients with breast cancer who fail to respond to antiestrogen drugs such as tamoxifen. Importantly, breast cancer cells from patients in whom disease recurred very rapidly after treatment with tamoxifen ...International scientists present the latest advances in RNAi and its clinical impact
...ical mechanisms of RNAi withthe aim of finding new anticancer targets. Antonio Girldez (HarvardUniversity, USA) studies the role of RNAis in zebrafish embryo development. Another topic of increasing interest is the drug delivery method of RNA molecules and how these interact with their targets. Jean-Paul Behr...Thyroid cancer discovery points to new treatments, prevention
... of the protein that may aid in the development of anticancer therapies. ...