Tailored treatments: Promising designer drug provides new insight into cancer biology
...ical ABT-737 is emerging as a unique and effective anticancer agent. The studies also demonstrate that pharmacological manipulation of specific signaling molecules can make resistant cancer cells sensitive to treatment with ABT-737. These studies provide support for the idea that examination of the molecular pr...Two drugs may stabilize plaques in atherosclerosis
...ronary events." SAHA already is being tested as an anticancer drug, and TSA is an antifungal antibiotic also being tested against cancer. The research is part of a larger project, supported by a $1,793,750 grant from the National Institutes of Health, to further develop the HDI class of drugs for the treatment ...Bacteria in small sea life yield new way to make potential cancer drugs
...em against predators. Many of these chemicals have anticancer properties, but harvesting them in quantities for large-scale testing and production has been impractical. The new method uses genetic pathways in the bacteria to produce the small chemicals and to manipulate them to invent new potential drugs. Th...Grape seed extract halts cell cycle, checking growth of colorectal tumors in mice
...toxic doses, by which grape seed extract can offer anticancer benefit in mice....Yale and NFCR launch Research Center for Cancer Drug Design and Discovery
...ology platform for more effective and long-lasting anticancer drugs. "This new center provides a vital link a...ug design that will undoubtedly lead to new, novel anticancer drugs that will help save lives," said Franklin Salisbury, Jr., President of the National Foundation...Study reveals mechanism for cancer-drug resistance
...e to undergo mutations that make them resistant to anticancer drugs," said Dr. Michael Roth, professor of biochemistry and senior author of a paper published this week in the online edition of the Proceedings of the National Academy of Sciences . One way that cancer cells resist multiple drugs is through th...Super chow, laced with semi-synthetic vitamin E derivative, inhibited spread of cancer in mice
...these synthetic derivatives, but they show amazing anticancer properties, and they selectively target tumor cells," Akporiaye said. To make the synthetic vitamins water soluble (not fat soluble like natural vitamin E), researchers have added sodium hydroxide. In this way, these vesiculated forms, called V-T...Chemical genomic screening identifies novel therapeutic strategies for cancer
...ing strategy that serves as a tool for identifying anticancer compounds may significantly enhance the drug discovery process. Two research papers that describe using this exciting gene expression-based chemical genomic strategy to identify therapeutics for cancer phenotypes previously associated with a poor pro...Researchers image molecular motor structural changes
...rgo unchecked cellular division, might lead to new anticancer therapies. The team, from Duke University Medical Center, the National Institute of Advanced Industrial Science and Technology in Japan, and the Medical Research Council's Laboratory of Molecular Biology in the United Kingdom, reported its findings ...Over the edge: New therapeutic strategy takes advantage of stressed cancer cells
...ant cells that are often resistant to conventional anticancer drugs may be sensitive to compounds like PEITC because of their high intrinsic ROS stress," says Dr. Huang....UW-Madison researchers find new way to 'sweeten' key drugs
...d on nature's chemical creativity to make critical anticancer agents and antibiotics. Writing this week (Sept. ...s Thorson. "There are a number of antibiotics and anticancer agents this can be applied to." In nature, plants and other organisms such as bacteria make many che...Dartmouth research points to protein S14 in treating breast cancer
...Because of this, Kinlaw explains, S14 may be a new anticancer target for breast cancer patients. Second, in the July 2006 issue of Breast Cancer Research and Treatment, Kinlaw and fellow Dartmouth researchers Bernard Cole, Peter Morganelli, Gary Schwartz, and Wendy Wells published a study that connected the a...Other highlights in the August 16 JNCI
... tumors is one factor that determines their actual anticancer activity. Kevin O. Hicks, Ph.D., of the University of Auckland in New Zealand, and colleagues measured the ability of tirapazamine, a drug activated in oxygen deficient cells, to penetrate cell layers of a type of colon cancer. With this informatio...Novel pathway identifies rapamycin as tumor angiogenesis inhibitor
...an immunosuppressant and under investigation as an anticancer therapy. The findings appear in the August issue of Cancer Cell, published by Cell Press. Compared to normal blood vessels, blood vessels associated with tumors are large, twisted, and leaky. Previous research has shown that overexpression of the c...Experimental RNA-based drug kills prostate cancer cells effectively and safely
... attempts to transform silencing RNAs into natural anticancer agents, but such development has been challenging," said Paloma Giangrande, Ph.D., co-leader of the study and an assistant research professor in experimental surgery. Scientists have encountered major obstacles when trying to deliver silencing RNAs...Boosting killer cells might improve breast-cancer drug
...he effectiveness of Herceptin, and perhaps similar anticancer drugs." ...AACR awards $2.6 million in grants for metastatic colon cancer research
...own to cause up-regulation of IL24 - a very potent anticancer protein. SC144 will be fully evaluated in mouse models and then, potentially, trials will be extended to humans. Boris C. Pasche, M.D., Ph.D., Northwestern University, "Targeting the TGFBR1*6A in Metastatic Colon Cancer." This study will use a...Other highlights in the June 21 JNCI
...ouse model of pancreatic cancer to investigate the anticancer activities of tolfenamic acid and related compounds. Contact: Stephen Safe, 979-845-5988, ssafe@cvm.tamu.edu KGF and FGFR2b Are Players in Cancer and Cancer Therapy Keratinocyte growth factor (KGF) is used to limit epithelial tissue damage fro...Activation of microRNA inhibits cancer gene in human cancer cells
...atment with chromatin-remodeling drugs may have an anticancer effect. "Taken together, our results suggest an effect of epigenetic treatment that couples inhibitors of DNA methylation and histone deacetylation to induction of some miRNAs. These miRNAs can potentially regulate expression of target genes that ar......en randomly assigned to receive treatment with the anticancer drug paclitaxel, imatinib, imatinib and paclitaxel or water (control). Treatment with imatinib or with imatinib plus paclitaxel resulted in prostate bone tumor regression and inhibited lymph node metastasis. Contact: Laura Sussman, 713-745-2457, ls...