UK markey cancer center receives FDA approval to test novel cancer drug
...ether to develop the next generation of a class of anticancer drugs that include the currently used drugs topotecan (ovarian and lung cancer) and irinotecan (colon cancer). At the time of DB-67's initial development and testing, pharmaceutical company Novartis licensed the drug. But after Burke died, the compan...Study finds racial differences in response to treatments for advanced colon cancer
...en known as FOLFOX4, a combination of the standard anticancer drugs 5-fluorouracil (5-FU), leucovorin (LV) and the new drug oxaliplatin. In that trial, patients were assigned to one of three chemotherapy programs. Each program called for the patient to receive two of three drugs; 5 Fluorouracil, irinotecan or...Genes raise risk of heart disease after treatment for childhood cancer
...s studied anthracyclines, a commonly used class of anticancer drugs known to cause heart damage in some patients...assify gene variations that modify side effects of anticancer drugs, they may be able to better tailor treatment plans to individual patients. Thus, knowledge of ...New treatment option breaks Leukemia's resistance to chemotherapy, radiation therapy
...provides the foundation for the discovery of novel anticancer compounds and the development of methods to sensitize previously resistant tumor cells to anti-cancer therapy," said Friesen. Researchers will now "focus on identification of novel molecular targets using gene expression technologies and high-throu...Researchers make vitamin E offshoot a potent cancer killer
... potent chemopreventive agent that has both strong anticancer and antioxidant properties," says principal investigator Ching-Shih Chen, professor of pharmacy and of internal medicine and a researcher with the OSUCCC-James. "Such an agent might help reduce the risk of prostate, colon and other cancers." Chen a...Arthritis drug might reduce fatigue in cancer patients
...Although TNF historically has been studied for its anticancer properties, recent studies indicate that TNF probably promotes tumor growth instead of hindering it. The drug etanercept is a decoy receptor that blocks interaction with TNF. The researchers hypothesized that the drug might therefore work like a spo...Inhibition of iron-metabolizing enzyme reduces tumor growth
...y by currently available drugs can represent a new anticancer tactic in the treatment of Kaposi's sarcoma and may be of potential clinical interest after more extensive investigation," says Marinissen. "The inhibitor that we used in this study is a tin-protoporphyrin. A recent clinical trial showed that the inh...Other highlights in the April 19 JNCI
...ggest ZSTK474 should be investigated further as an anticancer drug. Contact: Takao Yamori, Japanese Foundation for Cancer Research, Yamori@jfcr.or.jp...New model of p53 regulation proposed that suggests novel anticancer strategy
... has important implications for the development of anticancer drugs. This new model, published in the April issue of the journal Cancer Cell, emphasizes the independent role of two proteins, called Mdm2 and Mdm4. Both proteins are part of the tightly controlled system of checks and balances ensuring that p53 ke...Enzyme crystal structure reveals 'unexpected' genome repair functions
...In addition, NER is critical to the success of the anticancer drug cisplatin, since cisplatin works by initiating the process of DNA repair, in turn activating apoptosis or programmed cell death when the repair process fails. "Because chemotherapeutic agents like the chemotherapy drug cisplatin and radiation th...Highlights of American Chemical Society meeting in Atlanta, March 26-30
...e in Atlanta. The researchers used an experimental anticancer agent called dibenzoylmethane (DBM), a natural compound derived from licorice root that has shown promise in early cell studies for slowing the growth of prostate cancer cells. In tests with DBM, the compound inhibited growth of the Caucasian cell li...Liver cancer linked to cellular repair pathway
...ick said. "There is a desperate need for effective anticancer treatments that are safe for patients with liver disease." The results will be published in the April 4, 2006, issue of Carcinogenesis. The research was funded by the National Institutes of Health. Finding the overactivated Hedgehog pathway in liver ...'Custom' nanoparticles could improve cancer diagnosis and treatment
...roviding a more targeted and effective delivery of anticancer drugs than conventional medications or any of the ...organic materials that can contain imaging agents, anticancer drugs, DNA (for gene therapy) and other materials, depending on the intended function, DeSimone says...Light activated anticancer drug targeted to DNA using cisplatin like sub-units
...esearch to create a DNA targeting, light activated anticancer drug will be presented at the 231st American Chemi...bing PDT agents and cisplatin like units. Previous anticancer molecules created by the group have contained platinum-based molecules that bind DNA. They have also...Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin
...ng jams and jellies, but its uses are vast. It has anticancer properties, for instance, and may have a role in important biological functions including plant growth and development and defense against disease. Despite the importance of pectin as a major component in the primary walls of plants, scientists have ...New cancer therapies at international conference in Amsterdam
...eatment of cancer. Several new, so-called targeted anticancer agents are likely to be approved for use in daily ...ng the Opening Ceremony on March 16. Many targeted anticancer therapies, covering a wide variety of targets in tumor tissue or the tumor's environment, are the su...'Shuttling' protein possibly key to resilience of cancer cells
...o the cytoplasm might improve the effectiveness of anticancer treatments. "Ultimately, we are trying to figure out how to make the cancer cells more sensitive to chemotherapy and radiation treatment by keeping the ATF2 in the nucleus," Hu said. The Purdue researchers tracked ATF2 and other proteins using a fluo...Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells
...d low toxicity. There are currently eight approved anticancer antibody products on the market today and many more are in development. Unfortunately, many marketed treatments lack the desired potency against tumor cells, providing only incremental improvements in therapeutic success, and many development-stage a...MRI drug may improve cancer-killing ability of chemotherapy, study says
... Journal of the National Cancer Institute . Many anticancer drugs work by increasing the levels of tumor cell ... mangafodipir may enhance the therapeutic index of anticancer agents by both protecting normal cells and increasing antitumoral activity of these agents," the aut......art), the discovery and preclinical development of anticancer agents that show selective inhibition of certain types of cancer (Fenical), and the discovery of a neurotoxic amino acid found in certain marine algae that has been implicated in the amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PD...