Fruit fly reveals a potential connection between dementia and cancer
...cle was genetically blocked or when flies were fed anticancer drugs. Cell-cycle activation depended upon a hyper...these causal connections, this study suggests that anticancer drugs are potential therapies for Alzheimer's disease and related disorders. More broadly, the resul...Five European laboratories forms a concerted effort to understand tumor-host interactions
...project is to unravel and validate new targets for anticancer therapy, and new strategies for delivering therapy to tumors. "We are studying the molecular and cellular interactions between the normal, benign cells of the tumor microenvironment, and the cancer cells. These interactions represent an attractive t...Tips from the Journals of the American Society for Microbiology
...ers to examine the effect of infection with EBV on anticancer drug treatment. In the study biopsy specimens of ..., the impact of EBV infection on the efficiency of anticancer treatment might be of importance," say the researchers. (H. Arbach, V. Viglasky, F. Lefeu, J.M. Guin...Stopping the clock: Genetics of tumor latency in skin cancer
...f Gli protein stability may thus represent a novel anticancer therapy. "We hope our studies will lead to ways to enhance the cell's ability to get rid of Gli and halt cancer development," adds Dr. Oro....Academy honors 15 for major contributions to science
... synthesis of carbohydrates for the development of anticancer vaccines." The award, supported by The Merck Company Foundation, has been presented since 1979. NAS AWARD FOR INITIATIVES IN RESEARCH a prize of $15,000 awarded annually to recognize innovative young scientists and to encourage research likely to ...Tumor cells that border normal tissue are told to leave
... also has developed a robotic system for screening anticancer drugs, and they plan to use this system to look for drugs that will affect the metastatic process in their fruit fly model. "A drug that can prevent metastasis would be an important adjunct for cancer treatments," Cagan says. "It could cut a patient...Loosen leash on cancer protein 'watchdog,' researchers say
...k before this becomes a routine part of medicine's anticancer toolkit. "Essentially, this study validates Mdm2 as a potentially powerful chemopreventative for some kinds of hereditary cancer, and, if used properly, it might perform well without elevating the risks of aging that other groups have found. The bene...p53, tumor suppression and aging
...lays a critical role in cancer formation, and many anticancer strategies aim to activate p53 in order to curb tumor formation. Mdm2 is a key inhibitor of p53 and therefore an attractive target to modulate p53 activity in cells. However, conflicting evidence exists regarding whether or not p53-mediated tumor sup...'Computer-chemistry' yields new insight into a puzzle of cell division
...division. Solving the docking puzzle could lead to anticancer drugs to block the runaway cell division behind some cancers, said the researchers. Significantly, their insights arose not just from meticulous biochemical studies, but also from using sophisticated simulation techniques to perform "chemistry in th...Other highlights in the December 7 JNCI
...esearchers think that the compound displays potent anticancer activity, and they suggest that research move toward animal toxicity studies before clinical testing. Contact: Laura Sussman, Communications Office, M.D. Anderson Cancer Center, 713-792-0655, lsussman@mdanderson.org Also in the December 7 JNCI: ...Purdue biologists clarify how a cellular 'spacecraft' opens its airlock
...nts as to how. "Many cancer cells are resistant to anticancer drugs because the ABC proteins are overabundant and get too good at pumping the drugs out before they can work," she said. "Future therapies might exploit what we are finding out about these proteins' operation. It's too soon to talk about specific t...Plant gene related to cancer treatment may foster new oncology drugs
...istance process in which human cancer cells reject anticancer treatments," Murphy said. Results of the two studies suggest a previously unknown relationship between two protein families involved in this process, he said. Working together, the proteins apparently move molecules of the plant growth hormone auxin ...Innovative research set to push boundaries of cancer care
...o. Both of these compounds resemble the well-known anticancer chemotherapy drug doxorubicin, but have properties that are also unique, according to Priebe. In mice studies, one of the compounds, WP744 entered the brain and effectively treated cancer, increasing the survival time of the animals. This compound, n...Muscular dystrophy and cancer-associated muscle wasting share dystrophin dysfunction
...could also be considered as an option in designing anticancer cachexia therapies," concludes Dr. Guttridge....New European legislation impacts on both cancer trials and drug approval
...ures allowing early access to new drugs, including anticancer drugs. One of these measures is the 150 days accelerated procedure (instead of 210 days) for drugs that are of major public health interest, particularly in terms of therapeutic innovation. Moreover, renewable conditional authorisations may be grante...Gene therapy improves gemcitabine effects in experimental glioma model
...eutic efficacy and radiotherapy-sensitivity of the anticancer agent, gemcitabine, using gene therapy have yielde... by local tumour irradiation. As gemcitabine is an anticancer agent with established efficacy, use of gene therapy to increase its enzymatic activation was hypoth...Complementary new titles offer comprehensive view of antibiotics and resistance
...ique examination of the state of antimicrobial and anticancer drug resistance. Written by acknowledged experts...ding a comprehensive overview of antibacterial and anticancer drug resistance, with special emphasis on those areas where Levy stimulated scientific advances thro...Fetal exposure to toxins could be behind rise in asthma
...or autoimmune diseases and comprised antiviral and anticancer responses in later life. In his talk, Dietert pointed out the types of errors that can occur by relying on adult-safety data only. For example, far lower doses of toxins induce chemical changes in a fetus's immune system compared with an adult's, and...Inherited gene change also found in spontaneous tumors
... that the variant could be an important target for anticancer drugs. The research focused on the gene for type ...sts that the molecule would make a good target for anticancer drugs that block the action of the 6A molecule....$16 million grant advances nanomedicine at Washington University
...nano-scale sensors for rapidly screening potential anticancer drugs in single cells. "The investment in cancer-related nanotechnology by the NCI is a show of confidence that this technology will truly advance cancer treatment," says Larry J. Shapiro, M.D., executive vice chancellor for medical affairs and dean ...