Leading lampreys to slaughter: Pheromone for scourge of Great Lakes identified
...vel steroid akin to a shark steroid that possesses anticancer activity. This is the first migratory attractant to be identified in any fish. The work is the cover story for the November issue of Nature Chemical Biology and will be published online in the journal Sunday, Oct. 2. The lamprey is one of the earlie...NIH renews network focused on how genes influence drug responses
... variation in the molecular pathways that regulate anticancer drug responses. (Howard L. McLeod, Pharm.D., Washi...amine how genetic variability affects responses to anticancer drugs, including those used to treat childhood leukemia and colorectal cancer. (Mark Ratain, M.D., U...Molecular pathway linked to breast cancer recurrence
...entifies a potential target for development of new anticancer therapeutics. The research makes use of a unique mouse model of breast cancer that provides insight into the molecular and cellular events that lead not only to tumor development, but also to recurrence of the disease. The findings are particularly s...Purdue scientists treat cancer with RNA nanotechnology
... constructed tiny delivery vehicles that can carry anticancer therapeutic agents directly to infected cells, offering a potential wealth of new treatments for chronic diseases. The vehicles look nothing like delivery trucks, though that is their function once inside the body. Instead, these so-called nanopartic...Cancer drug target Chk1 may also be source of drug resistance
...in, known to be activated by an important class of anticancer drugs, may play crucial roles in both the hamperin...tressful conditions induced by hypoxia and certain anticancer drugs. Furthermore these same conditions target Chk1 for eventual destruction. Ironically, stimulat...Blocking a premature aging syndrome with anticancer drugs
A class of anticancer drugs currently being evaluated in phase 3 clinical trials may also be an effective treatment for Hutchinson-Gilford progeria syndrome (HGPS), a fatal genetic disorder that causes premature aging. If upcoming studies in a HGPS mouse model validate th...USC researchers find drug is tough tumor fighter
...y Schnthal and colleagues, showed that celecoxib's anticancer activity appeared to be independent from its COX-2 inhibition. Schnthal's team then went on to show that the analog in question-2,5-dimethyl-celecoxib or DMC-retains the ability to stop cancer growth despite the fact that it doesn't inhibit the acti...Cancer therapies during childhood can damage developing teeth
...owledge about the dental consequences of high-dose anticancer therapy preceding stem cell transplantation has so... of Helsinki, has studied the effects of high-dose anticancer chemotherapy and total body irradiation on the development of permanent teeth. Tooth development is...Virginia Tech group adds tools to DNA-targeted anti-cancer drugs
...e. For instance, they added platinum, a metal with anticancer activity because it binds to DNA inhibiting cell replication. "Using platinum assures that we are activating complexes that are already attached to the target," Brewer said. "The previous systems had an association with DNA but could release, which m...Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
...ated at the blood brain barrier that usually keeps anticancer drugs out of the brain, intercepted some of the JV-1-36 that was injected into mice but let much of it pass into the brain to treat cancer. "The blood brain barrier is set up to very carefully patrol what it lets into the brain and what it keeps out....Anti-fungal drug may help treat cancer
... in a manner that is similar to much more powerful anticancer drugs such as taxol and vinblastine," said Wilson....man use and could be used along with more powerful anticancer agents as an adjuvant in cancer chemotherapy." The authors found that the drug inhibits the prolif...The making and breaking of microtubules
...he journal Nature. "Tubulin is a major target for anticancer drugs, which can prevent the transition from growing to shrinking states or vice versa," says Nogales, who is also a member of Berkeley Lab's Physical Biosciences Division, an associate professor of biochemistry and molecular biology at the Universit...JCI table of contents, July 1, 2005
...o treat the infertility that arises as a result of anticancer treatment for childhood leukemia. A number of issues surrounding the harvest of such material from prepubertal children with leukemia, that could be safely stored and retransplanted into chemotherapy-damaged testes, have not yet been solved. These in...Physical and functional interaction of key cell growth molecules linked to cancer
...on of cancer will be useful for development of new anticancer therapeutics. In the current study, Dr. Mien-Chie ... This research may open new avenues for designing anticancer therapies against EGFR, STAT3, and iNOS/NO....MSKCC researchers uncover structure of key protein complex in cells
...ving SUMO's function could potentially yield novel anticancer therapies. "If sumoylation (when SUMO attaches to a protein) is promoting cell division, then inhibitors of SUMO may be a pretty good agent to block the cell cycle," said Dr. Lima. Postdoctoral researcher David Reverter, PhD, collaborated with Dr. L......p than that targeted by other clinically important anticancer drugs. "It uses a different mechanism to any known drug, it's unlike anything else," Molinski said. Chemists are now investigating phorboxazole and related compounds to see if they can be made more efficiently. "It's excited a lot of chemists and can...USC researchers determine mechanism of action of chemotherapy drug
...ellular zinc levels have potential applications as anticancer therapeutics."...Use of PET can reduce, may eliminate more strenuous drug development trials with animals
...rocesses to drug development and early response to anticancer and gene therapy. In addition, small animal imaging significantly reduces the preclinical evaluation time for therapeutic pharmaceuticals, possibly speeding the way for innovative drugs to patients, said Welch. Since there is no public registry of an...Chemokines orchestrate more than migration for immune cells
...useful for rational design of future antiviral and anticancer therapies.......ed a novel compound with promising potential as an anticancer agent. From the library of screened compounds, Sho... reductase 1 (CBR1), that acts on xenobiotics like anticancer drugs and is thought to cause the heart damage associated with daunorubicin chemotherapy. The author...