Neutralizing a protein linked to tumor development
...olecules - called aptamers - may have potential as anticancer drugs. Aptamers - single-stranded nucleic acid molecules that are 50100 bases long and can be selected for their ability to bind directly and tightly to specific proteins - are less likely to be targeted and destroyed by the body's natural defenses t...Highlights of chemical society national meeting in San Diego, March 13-17
...roducts Many antibiotics, immunosuppressants and anticancer agents are based on a class of natural compounds called polyketides, small but complex molecules produced in bacteria and fungi in tiny amounts. Limited yields from natural sources and the difficulty of making them synthetically has limited their sup...TAT2005 - 3rd International Symposium on Targeted Anticancer Therapies
...ncerning the new generation of rationally designed anticancer agents with well defined molecular targets in the ...neers in the development of this new generation of anticancer agents. Another highlight of the TAT 2005 program will be a Plenary Session on Friday, March 4 (8:30...Purdue proves concept of using nano-materials for drug discovery
...he cells to become progressively more resistant to anticancer drugs. Engineers and scientists in the Purdue center are trying to find drugs that deactivate the pumps, which would make the chemotherapy drugs more effective. The researchers are developing synthetic cell membranes to mimic the real thing and then ...New drug may be formidable adversary for hard to treat leukemia
...nt cancer cases. Despite the resounding success of anticancer drug imatinib (Gleevec) as a treatment of chronic myeloid leukemia (CML), a small but growing number of patients develop resistance to the drug and relapse. Imatinib inhibits the activity of Bcr-Abl, a protein that is abnormally active in most CML p...Promising anti-TB compound finally can be synthesized with ease
...against TB and are potential anti-inflammatory and anticancer agents. "We're poised now to make them all and to develop new analogs as potential medications," said Huw Davies, Ph.D., Larkin Professor of Organic Chemistry at UB and co-author. Once thought to be nearly eliminated, tuberculosis is ag...Chemists create 'Superbowl' molecule; May lead to better health
...will be able to encapsulate compounds such as [the anticancer drug] taxol in the near future," he says, but cautions that the superbowl molecule has not yet been tested in animals or humans. Until then, no one knows yet when this experimental molecule will actually enter the consumer market, but any useful appl...Scientists find common roots for thousands of plant compounds
...o make thousands of compounds, from molecules with anticancer properties to the active ingredient in catnip, according to a team of researchers at Purdue University and the Max Planck Institute for Chemical Ecology. This finding challenges long-held assumptions about how plants produce these commercially import...New cancer gene identified by Memorial Sloan-Kettering scientists
...ein's function in the same way could be a powerful anticancer agent. "Pokemon is a main switch in the molecular network that leads toward cancer," Dr. Pandolfi added. "If we could turn Pokemon off, it may block this oncogenic circuitry and stall the malignant process." The investigators confirmed Pokemon's can...Combination therapy boosts effectiveness of telomere-directed cancer cell death
...s, and has been identified as a logical target for anticancer therapeutics. However, recent studies indicate that for this therapy to be effective, telomeres must be in a critically short state, requiring an extended treatment duration that can lead to drug resistance and other problems. Dr. Hiroyuki Seimiya fr...JCI table of contents, December 15 2004
...iculty in translating these results into effective anticancer therapies is the need to consider the important role that platelets play in arresting bleeding, for example in the event of a nosebleed or following injury or surgery. In an accompanying commentary, Gaorav Gupta and Joan Massagu from Memorial Sloan-K...Vitamin E in plant seeds could halt prostate, lung cancer, says Purdue scientist
... cells unaffected, which could give it value as an anticancer agent. "This is the first time gamma-tocopherol...t form of vitamin E that alone does not have these anticancer properties, it may be better to supplement the diet with mixed forms of vitamin E. The study shows t...Purdue scientists hunt for 'secret X' to treat liver cancer
...ences liver cell behavior could be harnessed as an anticancer therapy, turning the X protein's presence in the liver to patients' advantage. "Instead of chemotherapy, drugs that influence the X protein's behavior might become an alternative cancer therapy," said Andrisani, a professor of basic medical scienc...Cloned gene from sea animal may prove key in cancer drug development
...p solve problems associated with the production of anticancer agents originally discovered in the marine invertebrate Bugula neritina. "To be able to show that this gene really exists has been the Holy Grail for the last 10 years," said Scripps Professor Margo Haygood, a coauthor of the paper. "This takes us be...Other highlights in the November 17 JNCI
... resistant to cisplatin to become sensitive to the anticancer drugs. They suggest that this strategy may be useful for treating human solid tumors that are drug resistant or even for increasing the efficacy of antitumor drugs in drug-sensitive tumors. Contact: Mirella Taranto, Press Office, Instituto Superiore ...Signal for inflammation linked to Ras-induced tumor growth
...hemokine and its receptors may serve as attractive anticancer therapeutic targets." Anke Sparmann and Dafna Bar-Sagi: "Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis" ...Structure of new DNA enzyme family member found
...y riboside kinase as a laboratory tool for testing anticancer drugs and other pharmaceuticals. The group also is working to get the structure of other riboside kinase family members in order to be able to predict the proteins' function....Gene found to defend against environmental pollutants and pulmonary emphysema
... to show that activation of Nrf2 in response to an anticancer agent--Sulforaphane--can turn on antioxidant genes, but little was known about Nrf2-regulated genes and their role in lung inflammatory diseases caused by chronic exposure to environmental agents. By exposing mice to cigarette smoke, the researchers ...Discovery might improve design, effectiveness of anti-cancer drugs
...ive in blocking that enzyme's action in destroying anticancer drugs," said Dr. Richard V. Wolfenden, Alumni Dist...r, this specific enzyme is known to inactivate the anticancer agent cytarabine," he said. "That inactivation limits the effectiveness of cytarabine in cancer tiss...S1P1 essential for tumor growth and is blocked by RNA interference
...RNA interference technology may be of great use in anticancer therapies. TITLE: Requirement for sphingosine 1phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference AUTHOR CONTACT: Timothy Hla University of Connecticut Health Center, Farmington, CT 06030, USA Phone: (860) 679-4128;...