Highlights of chemical society national meeting in San Diego, March 13-17
...RESENTATION, UNLESS NOTED OTHERWISE SAN DIEGO An antioxidant mixture that may help prevent skin cancer , efforts to genetically engineer bacteria for the mass production of antibiotics, and novel gene therapy vectors that employ the herpes simplex virus to help fight chronic pain and brain cancer are amon...Antioxidant blood levels key to MnSOD gene
...tase (MnSOD), an important enzyme that works as an antioxidant in human cells to defend against disease. The MnSO...th the AA genotype seemto be more sensitive to the antioxidant status," said Li. "Men with the AA genotype are moresusceptible to prostate cancer if their antioxi...Defenseless plants arm themselves with metals
...duction of a molecule called glutathione, a potent antioxidant that protects plants from metal. Because the production of glutathione is tied to the production of salicylic acid, most plants normally have fairly low glutathione levels and, consequently, can't tolerate metals. Thlaspi, on the other hand, is brimm...Protein delivers selenium for normal sperm development
...own, although it was believed to play a role as an antioxidant and to transport selenium throughout the body. Dietary selenium is essential for normal sperm development and male fertility. Selenoprotein P, or SEPP1, carries about 60 percent of the selenium in blood plasma. To understand the physiological functio...UT Southwestern researchers see hope for treating blindness in preemies
...xygen environment by stimulating the production of antioxidant molecules and promoting blood and blood vessel for...h-needed oxygen. Biochemical tests revealed that antioxidant genes turned on by HIF-2a were inefficiently activated when HIF-2a was missing. In addition, the ge...Drought reduces nitrogen-fixing in legumes
...posed to water stress of abscisic acid - a natural antioxidant was decided upon. Treatment with exogenous abscisic acid, carried out under conditions of water stress, played a beneficial role on the protein content of the plant. Likewise, a recovery in the total activity of the metabolism carbonand nitrogen enz...Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
...n of glutathione. Glutathione, part of the plant's antioxidant system, may be buffering the impact of the contaminants, said the researchers. The ECS and GS lines absorbed 2.8 times and 2.3 times more selenium respectively than the wild plants. Moreover, the GS plants seemed particularly tolerant of the contami...Don't count on vitamin C to boost your exercise performance
...ult of increased production of ROS, a reduction in antioxidant defenses, or both. Recent evidence suggests that i...cute intra-coronary administration of the powerful antioxidant ascorbic acid." However in the current experiment, Bell et al. found that after a month of ingesting...Oxidants link obesity to diabetes
...und that treatment of these mice with apocynin an antioxidant that inhibits NADPH oxidase reduced ROS production in fat cells, restored adipocytokine production to normal, improved diabetes, and reduced the levels of fat present in the blood and liver. The results suggest that accumulated fatty tissue is a maj...JCI table of contents, December 15 2004
...und that treatment of these mice with apocynin an antioxidant that inhibits NADPH oxidase reduced ROS production in fat cells, restored adipocytokine production to normal, improved diabetes, and reduced the levels of fat present in the blood and liver. The results suggest that accumulated fatty tissue is a maj...Discovery about Vitamin C explains its metabolic value
...s Pauling Institute. "We knew that vitamin C is an antioxidant that can help neutralize free radicals. But the new discovery indicates it has a complex protective role against toxic compounds formed from oxidized lipids, preventing the genetic damage or inflammation they can cause." Some earlier studies done in...Red wine lovers, take heart: More evidence points to the drink's cardiac heath benefits
...arch on rat heart cells suggests that a well-known antioxidant found in red wine, called resveratrol, may benefit heart tissue by limiting the effects of a condition called cardiac fibrosis. Diseases such as hypertension and heart failure can cause fibrosis, a hardening or stiffening of the heart tissue. This co...Study: Eat leafy green veggies to help prevent cataracts
...the effects of these antioxidants to vitamin E, an antioxidant also thought to reduce the onset of eye diseases. ...ective effect. "The lens is equipped with antioxidant defense mechanisms designed to guard against the harmful effects of ultraviolet radiation and oxidat......PE) trial of 2000, designed to study the effect of antioxidant therapy such as vitamin E on cardiovascular risk. ...ants. Furthermore, haptoglobin 2-2 is a very poor antioxidant when compared to the other haptoglobin types. This combination means that diabetics with haptoglobi...Cardiovascular and neurological benefits of high antioxidant foods and beverages
...e cardiovascular and neurological benefits of high antioxidant foods and beverages, will present a briefing for j...gical benefits of grape juice, wine and other high antioxidant foods and beverages. WHEN: Thursday December 2nd, 2004, 3:30-5:00pm WHERE: The Algonquin...Concord grape juice increased HDL, lowered inflammatory marker linked to heart disease
...ave seen that Concord grape juice has shown strong antioxidant and platelet-inhibitory effects. This is the first study to show its positive effect on soluble CD40 ligand, an emerging marker of cardiovascular inflammation, even in subjects on a daily aspirin regimen." The double blind, placebo-controlled study ...By impounding iron, FHC foils cell suicide, fuels inflammation
...ogrammed cell death. "The data indicate that the antioxidant activity of FHC involves iron sequestration and that this sequestration is crucial for suppression of death of white blood cells induced by proinflammatory factors," the authors note. These findings identify FHC as the mechanism "by which NF-kB cont...JCI table of contents November 1, 2004
...lysis provided evidence of about 50 Nrf2-dependent antioxidant and cell-protective genes in the lung that might function together to protect the lung from cigarette smoke-induced emphysema. These data suggest that the Nrf2 pathway provides protection from emphysema by turning on antioxidants and suppressing infl...Gene that blocks free radical damage protects against emphysema
...lysis provided evidence of about 50 Nrf2-dependent antioxidant and cell-protective genes in the lung that might function together to protect the lung from cigarette smoke-induced emphysema. These data suggest that the Nrf2 pathway provides protection from emphysema by turning on antioxidants and suppressing infl...Gene found to defend against environmental pollutants and pulmonary emphysema
...uch as cigarette smoke, and then turns on numerous antioxidant and pollutant-detoxifying genes to protect the lun... to an anticancer agent--Sulforaphane--can turn on antioxidant genes, but little was known about Nrf2-regulated genes and their role in lung inflammatory diseases ...