ENCODE map changes view of the human genome landscape
...tified and validated promoters were located on the antisense strand of annotated transcripts, mostly in terminal exons. The authors speculate that these promoters may regulate transcription that occurs in the reverse direction (antisense) to protein-coding genes. Future research will be necessary to determi...Almac Diagnostics announces pioneering genetic research on colorectal pre-malignancies
...tabase 7% of the content represents expressed antisense transcripts to annotated genes To date, Almac Diagnostics has launched Colorectal Cancer DSA and Breast Cancer DSA. Lung Cancer DSA will be launched in June, and Ovarian Cancer DSA and Prostate Cancer DSA will be launched later this year. A pipe...Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription
... more stable sense RNA/DNA duplexes than potential antisense RNA/DNA duplexes. "The difference between stability of sense and antisense mRNA/DNA is a property that can aid gene discovery," explains Stoynov. "Thermodynamic stability of...CSHL shows correcting RNA splicing may help treat spinal muscular atrophy
Cold Spring Harbor, New York -- RNA splicing antisense technology studied at Cold Spring Harbor Laborator...SHL Professor Adrian Krainer, Ph.D. RNA splicing antisense technology allows researchers to influence the ultimate structure and function of proteins. Proteins...Scientists discover role for dueling RNAs
...overed that in the case of a gene called IME4, the antisense RNA blocks the sense RNA. In other words, the gene...ase where a specific function in a higher cell for antisense RNA has been found," says Fink, senior author on the paper. "This points to an entirely new process...American Andrew Z. Fire shares Nobel Prize for discovering RNAi
...researchers mixed sense RNA with a small amount of antisense RNA, and the two strands together generated the si... earlier experiments had included trace amounts of antisense RNA, thus causing the RNA interference. The Man behind the Prize Fire, a California native, rece...Researchers discover that sheep need retroviruses for reproduction
...on of the envelope of the enJSRVs using morpholino antisense oligonucleotides, which inhibit translation of specific messenger RNA. When production of the envelope protein was blocked in the early placenta, the growth of the placenta was reduced and a certain cell type, termed giant binucleate cells, did not ...JCI table of contents: July 27, 2006
...rier via the blood, therapeutic molecules known as antisense oligonucleotides can be delivered to the brain and...Smith, and colleagues delivered effective doses of antisense oligonucleotides throughout all brain regions affected in the major neurodegenerative diseases and t...Protein from the wrong side of the tracks aids cancer virus
... the virus's DNA molecule. Such genes are known as antisense genes, and they have been observed in only a few r...alled the sense strand. The opposite strand is the antisense strand, and it generally carries no genetic information. But HTLV-1 is a rare exception. Of its eig...Gold nanoparticles could improve antisense cancer drugs
EVANSTON, Ill. --- In the fight against cancer, antisense drugs, which prevent genes from producing harmful ... now have demonstrated a new method for developing antisense drugs that outperform conventional antisense agents. The findings will be published May 19 in the jo...News tips from The Journal of Neuroscience
...o the PO/AH. Chicks whose BDNF was knocked down by antisense treatment during the critical period had persistent difficulty in regulating body temperature, and chicks that received heat conditioning during the critical period fared worse than those that did not. 3. Retinal Gain Control Felice A. Dunn, Thuy D...Ocean virus identified in human blood samples
...oPharma has investigated their proprietary NeuGene antisense as an anti-Vesiviral treatment, and is currently conducting further research and development," said Patrick Iversen, a co-author on the study and senior vice president of research and development at the company. Researchers say that Vesivirus has nat...News tips from the Journal of Neuroscience
...oach, REST translation was blocked by a morpholino antisense oligonucleotide (MoXREST). Activation of dnXREST resulted in decreased expression of several neuronal genes at the late blastula stage. But perhaps more importantly, XREST was required for neuroectodermal patterning during gastrulation, pointing to a...JCI table of contents, February 16, 2006
...epatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. AUTHOR CONTACT: Gerald I. Shulman Yale Medical School, New Haven, Connecticut, USA Phone:(203)785-5447; Fax:(203)737-4059; E-mail: gerald.shulman@yale.edu View the PDF of this article...Gene-specific Ebola therapies protect non-human primates from lethal disease
...technology firm. According to the study's authors, antisense drugs are useful against viral diseases because th...irus." Working with a class of compounds known as antisense phosphorodiamidate morpholino oligomers, or PMOs, the team first performed a series of studies to id...Alcoholism research reveals promising new approach to treating Alzheimer's disease
...version of Peptides. "We found that we can develop antisense which is a molecular compound to cross the blood...ity research has found that scientists can develop antisense to cross the blood brain barrier and lower levels of amyloid beta protein in mice. Banks tested whet...Understanding IGF-1: Jefferson researcher sees drug potential in targeting enzyme
...s ago, for example, Dr. Baserga and his group used antisense therapy to target the IGF-1 receptor, which killed cancer cells in mice but didn't work as well in people. However, clinical trials are just beginning, he says, and he is still hopeful that other approaches will work in humans. In the meantime, pharm...Other highlights in the September 7 JNCI
...Centre, and colleagues, has found that OGX-011, an antisense oligonucleotide to clusterin, is well tolerated and reduces expression of clusterin--a protein that promotes cell survival--in prostate tumors. Contact: Papinder Rehncy, BC Cancer Agency, 604-877-6261, prehncy@bccancer.bc.ca Also in the September ...Mammalian transcriptome mapped, and it makes antisense
...ical research, medicine, and biotechnology because antisense genes are likely to participate in the control of ...e transcriptome project is that there are far more antisense genes than anyone ever knew. Some genes have been known for a long time to have antisense counterpar......lter liver insulin action. Here, the authors used antisense technology to block insulin receptor expression in mice, but this approach did not modify rates of glucose production by the liver. An accompanying commentary by Alan Cherrington discusses both papers. Cherrington writes, "taken at face value, these...