Researchers rein in regulatory RNAs
...NA (dsRNA) molecules. A large proportion of these antisense RNAs represent non-coding RNAs. Thus, the researchers expect that these results will lead to a better understanding of roles of non-coding RNAs in gene regulation....JCI table of contents, April 1, 2005
...sorders. TITLE: Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1 AUTHOR CONTACT:Bei Zhang Merck Research Laboratories, Rahway, NJ USA Phone: (732) 594-1926; Fax: (732) 594-3750; E-mail: bei_zhang@merck.com View the PDF of this article at: ...MUHC researchers make cancer target breakthrough
... the growth of tumors." Researchers found that the antisense reduced lung and colon cancer tumors in both labor...tissue cultures and in mice. "Discovering that the antisense works in animal models is a major step forward, and gives us hope that this might also work in human...Tailing the cause of a rare heart disease
...als. In their experiments with the fish, they used antisense genetic techniques to reduce the fish's production of eya4 protein and measured the resulting changes to the heart. The treated fish developed swelling of the heart ventricle that suggested cardiac dysfunction. High-speed video of the fish's beating ...Carnegie Mellon scientist develops way to deliver promising genetic tool into living cells
...roteins, is the target of an emerging field called antisense therapy. "We found that we could modify PNAs so that they bind sequence-specifically to mRNA," Ly said. By binding to specific mRNAs, these agents could dampen the production of select disease-causing proteins, he added. First reported in the early 1...