NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
...addressing the problem of protein stability. One approach will be to build on the work that has been done us...en used before, there has never been a generalized approach to creating such a scaffold. As part of the grant, the team plans to synthesize and test a matrix of...32 new grants made for innovative technology R&D
...g diode (LED) lamp package with an integrated chip approach that would more than quadruple the brightness and ...nics and optoelectronics applications, by using an approach that incorporates new techniques of crystal seed growth, coupled with advanced thermal gradient cont...Commandeering cellular machinery: recognition mechanism to detect small molecules
...e," Doyle said. "We are trying to generalize this approach to genetic selection. There is a lot of diversity we can work with in terms of different binding pockets and shapes, so this is only the first step."...A treatment, not a cure: Calcium silicate neutralizes an acidic stream
...r. Gene E. Likens, with colleagues, explores a new approach to restoring acidified streams, the addition of calcium silicate. The paper is the first to document the neutralizing effects of Wollastonite, a calcium silicate, on an acidic stream. The research was performed at the Hubbard Brook Experimental Fore...Daphne Koller named MacArthur Fellow
...dard deductive reasoning. The strength of this approach is that it has the ability to represent models of the world with significant complexity. "So far, most models have been fairly self-contained -- but the world does not work that way," Koller said. These models have already seen service in anal...Putting physiology into the Nobel Prize: 2004 marks 100th anniversary of Pavlov's award
...aps the most unusual aspect of Pavlov's career and approach to science, Smith believes, was that shortly after receiving his Nobel Prize in 1904, Pavlov would change his research program at the age of 55 andgo on to invent a new field research, e.g., the investigation of conditional reflexes that he actively ...Interactive health information system to detect Japanese encephalitis in Asia
... Asia. "Voxiva's innovative approach holds huge potential, because the system allows the information to be immediately available to all levels of the health system," said Dr. Julie Jacobson, PATH's Director of the Japanese Encephalitis Project. "Surveillance will be made easier by usin...Component of volcanic gas may have played a significant role in the origins of life on Earth
...uble problem is also deluded." One possible approach to the problem of life's origins is to ask the question scientifically rather than historically-- how can life emerge rather than how did life emerge. In order to address this, scientists try to determine experimentally what is chemically feasible an...T cell's memory may offer long-term immunity to leishmaniasis
...aused the disease. Their findings encourage a new approach to creating a vaccine against leishmaniasis and other immune cell mediated diseases such as tuberculosis and HIV/AIDS. Attempts to create a vaccine for leishmaniasis have long been stymied by the fact that the helper T cells, which coordinate the im...Taking the next step toward growing our own fuel
...gram will focus on an integrated multidisciplinary approach towards replacing the petroleum-based economy with a biobased economy that uses agricultural crops as the platform. "The U.S. has access to significant amounts of biobased resources, including those of the highly productive corn/soybean croppi...US Agency for International Development awards $34 million to Virginia Tech
...p and implement worldwide a replicable, integrated approach to pest management that will reduce agricultural losses, mitigate damage to natural ecosystems, and prevent contamination of food and water supplies. "The program will be designed around Regional IPM Centers of Excellence and cross-cutting global IPM...Children's Hospital Boston wins $2.5 million in health surveillance grants
...es Mandl. "Until now, there has been no agency to approach for major funding of public health research," he says. The pilot projects at Children's will further a new federal agenda to improve the nation's health information infrastructure. In July, Tommy Thompson, the U.S. Secretary of Health and Human Serv...Mitochondria findings may help beat wide range of disease
...both light and electron microscopy. This cell-free approach allowed researchers a first-ever glimpse into the sequence of events underlying outer and inner membrane fusion. What they discovered -- that mitochondria removed from their host-cell environment were nonetheless able to fuse -- surprised them beca...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...ness, a fundamental problem with this conventional approach is that the snapshots are not only taken at differ... toxic proteins and prevent neurodegeneration. The approach developed by the Finkbeiner group -- combining the use of a robotic microscope with powerful techniq...Study using robotic microscope shows how mutant Huntington's protein affects neurons
...l might be a more effective approach. "This approach provides a way to connect cellular changes to fate," says Dr. Finkbeiner. The automated microscope system could be applied to sort out many important questions about how cellular changes or abnormalities affect disease, he adds. He and his colleagu...Where in the brain decisions are made
... colleague Michael Dorris have used a game-playing approach to demonstrate that a region of the cortex called the lateral intraparietal (LIP) area is active when monkeys are making subjective internal decisions about the desirability of an action--in this case, moving their eyes to a target. According to the ...NHGRI seeks next generation of sequencing technologies
...technologies. This is a highly parallel sequencing approach that involves synthesizing short regions of identi...dual DNA molecules. This group will pursue a novel approach in which a nanopore is used to simultaneously detect electrical and fluorescent signals from many na...Surgeon General's report underscores the importance of new thinking on bone health
...eon General called for a coordinated public health approach that brings together a variety of public and private stakeholders in a collaborative effort to improve bone health. "The greatest challenge always has been to drive home the importance of osteoporosis prevention. For decades, too many people have no...Sniffing out the culprits of dust allergies
...earchers devised and used a novel combined-library approach for this purpose--a method that enabled simultaneo...s. This study demonstrates the utility of this new approach for quickly identifying active proteases involved in allergic responses or other disease processes a......s so far proved difficult to carry out -- a better approach may be a drug that assures the sustained, low-level MC4R activity that the researchers showed is essential for the protein to regulate appetite. "These findings provide a whole new way of thinking about how hormone receptors could cause disease, and ...