Common mechanisms for viral DNA replication
... In both cases, DNA binding is thought to initiate assembly of a complex of the full-length proteins on DNA. I...ding, we present a model describing the subsequent assembly events....Microtubule protein interactions visualized en masse
...cell's shape) become very short and dynamic before assembly of the mitotic spindle (the structure that pulls chromosomes apart). Although it is known that the CDK1 kinase induces this reorganization, the precise mechanisms that regulate such coordinated changes are not yet understood. There are two known m...TIGR researchers reveal tricks of common sexually transmitted infection
...me has never been described before and made genome assembly particularly difficult. Only one class of drugs, the 5-nitroimidazoles such as Flagyl, is approved for treatment of trichomoniasis, and T. vaginalis is developing resistance to them. The researchers identified mechanisms that may help the parasite ...Structure of iron regulatory protein-RNA complex solved
...n important metabolic enzyme called aconitase. The assembly and disassembly of the iron/sulfur cluster in the aconitase form appears to be an effective mechanism for regulating IRP1 activity. "We found that when IRP1 releases the iron/sulfur cluster and opens up to bind RNA, it undergoes an extraordinary, u...Treatments for urinary infections leave bacteria bald, happy and vulnerable
...parts of the pili from the inner membrane to their assembly site on the outer membrane. Hultgren's group determined the crystal structure of this protein and analyzed it to learn which regions of the protein needed to be blocked off by a pharmaceutical to prevent the chaperone from doing its job. To synthesi...Study gives clues about how deadly bacterium gains foothold
...two functions from working in part by blocking the assembly of certain enzymes. After a few hours, the bacteria can escape the compartment instead of being killed, which leaves it able to replicate and cause harm," Allen said. The researchers now seek to identify how the bacteria prevent neutrophils from m...Genetic variation: We're more different than we thought
...numbers or orientations, when comparing the Celera assembly to the public human genome sequence. The entire human genome is thought to contain about 3 billion nucleotides. The discovery of an abundance of DNA variation puts a whole new spin on the study of genetic disease. Most research has focused on small ...Yale Cell Biologist Joel Rosenbaum, to receive Prestigious Wilson Award
... in the cell body to the tip of the flagella where assembly takes place. Finally, in 1992, using new high-re...een an IFT particle gene that would block flagella assembly in Chlamydomonas when mutated and produce PKD in the mouse model seemed remote. Few had paid attent...U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
...e vaccines. The pathway can be thought of as an assembly line with a switch to turn it on, says Zhou. "If the switch is turned on, the pathway enables efficient production of more viruses. But only the NS1 protein can turn on the switch." The researchers are investigating genes and proteins of the influ...Carnegie Mellon scientist plays key role in unveiling sea urchin genome
...ird of the total genomic material critical for the assembly of the genome and for the accurate prediction of where genes lie within the DNA sequence. The Ettensohn lab was also one of 15 labs to annotate sets of genes that comprise the sea urchin genome. Initially, computers assembled the genome sequence and...News tips from the Journal of Neuroscience
...n protein interactions that lead to maturation and assembly of the fly neuromuscular junction. 2. Sensory Input and Olfactory Bulb Circuits Carolyn A. Marks, Kai Cheng, Diana M. Cummings, and Leonardo Belluscio Noses come in all shapes and sizes, but the internal wiring is remarkably consistent across s...Interdisciplinary grant to Yale: Creating nanodevices for delivery of vaccines
...de variety of antigens of clinical importance, and assembly of different combinations of recognition and antigen modules for a broad-spectrum potent vaccine response....Pulmonary hypertension discriminates by race, gender
...EST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians (ACCP), revealed that racial disparities exist in pulmonary hypertension mortality and morbidity, with African-American women exhibiting the highest mortality rate when compared with all other groups. "Idi...Genetic disorder linked to rapid lung function decline in some World Trade Center rescue workers
...EST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians (ACCP), shows that World Trade Center rescue workers deficient in the A1AT protein who were exposed to environmental irritants had more rapid decline in lung function compared with exposed workers with norm...Discovery about evolution of fungi has implications for humans, says U of M researcher
...r various relations. McLaughlin is directing the assembly of a shared database of fungal structures obtained through electron microscopy, which produces detailed images that provide clues to the diversity of these organisms. The work is funded by a $2.65 million "Assembling the Tree of Life" grant from the ...Molecular 'signature' protects cells from viruses
...esired protein are put together there on a kind of assembly line. In this process the assembly line follows exactly the blueprint which is stored in the relevant RNA. This method has an Achille...Researchers make nanosheets that mimic protein formation
...ction between the forces governing S-layer protein assembly and the forces governing the nanoparticle assembly. That's when Glotzer's group, whose expertise is in computer modeling and simulation, became involved. "It's likely that the forces between S-layer proteins are highly anisotropic, and we suspected...Nanoparticle assembly enters the fast lane
UPTON, NY -- The speed of nanoparticle assembly can be accelerated with the assistance of the mole...ng disease. Learning how to control and tailor the assembly of these miniscule particles into larger functional systems remains a major challenge for scientists...NHGRI aims to make DNA sequencing faster, more cost effective
...racy, re-sequencing of highly variable genomes and assembly of never-before sequenced genomes. Dmitri V. Vezenov, Ph.D., Lehigh University, Bethlehem, Penn. ,$905,000 (3 years),"Force Spectroscopy Platform for Label Free Genome Sequencing" This team will apply force spectroscopy, a technique used to und...Roger Kornberg to present Dickson Prize lecture at U of Pittsburgh's SCIENCE2006: Feel the Power
...tion encoded in DNA is transferred to the cellular assembly mechanism responsible for protein synthesis. Breakthroughs such as the discovery of the nucleosome the unit into which the DNA double helix and associated proteins called histones are compressed to fit within a cell's nucleus have resulted from Dr....