Enzyme crystal structure reveals 'unexpected' genome repair functions
...nit of Transcription Factor IIH (TFIIH) functional assembly complex, might play in changing conformations for TFIIH's alternate roles in either transcription or DNA repair. The XPB crystal structures developed by the researchers identified unexpected functional domains for XPB that, according to the study, h...Rice bioengineers pioneer techniques for knee repair
...would be making entire articular end caps via self assembly I would have said you were crazy," said Athanasiou. "The fact that we can do this is an indication of how far the discipline of tissue engineering has progressed." Unlike cartilage, most tissues in our bodies including skin, blood vessels and bone ...A new focus for the mechanism of nerve growth
...known that such advance depends on the coordinated assembly of actin filament networks. This study implicates the molecular motor, myosin II, as a key part of the process of recycling the actin networks and ultimately sensing and directing nerve growth. Proteins in the Myosin family function as molecular mot...A balancing act between the sexes
...es. Balance is achieved through the activity of an assembly of proteins, called the dosage compensation complex (DCC)." In flies the DCC hyperactivates the male X-chromosome to double the amount of proteins it produces. Investigating how this hyperactivation is brought about Akhtar's group discovered that the...Chemists report progress in quest to use hydrogen as fuel for cars and electronic devices
... -- and an organic component; he can control their assembly into new structures nearly at will. How would hydrogen work in devices like cell phones, laptop computers and digital cameras? "Instead of a battery, one would have a medium such as MOF that stores hydrogen and releases it into a fuel cell," he said....Study suggests that publicly available genome data may contain small but significant errors
...r as an independent method for validating sequence assembly and indicating where errors need correction. Comparing data from their inferred probe maps to the available sequence assembly, the new method provides insights into the difficulties of establishing a canonical and accurate sequence or physica...UCLA biochemistry professor Sabeeha Merchant wins prestigious research award
...Smith Medal "for her pioneering discoveries in the assembly of metalloenzymes and the regulated biogenesis of major complexes of the photosynthetic apparatus in green algae," the National Academy of Sciences said. The medal has been presented every third year since 1979. The National Academy of Sciences is a ...UW scientists unravel critical genetic puzzle for flu virus replication
... systematic -- as opposed to a random -- method of assembly opens the door to the development of new antiviral drugs and the harnessing of benign influenza viruses as gene vectors to optimize vaccine production, Kawaoka says. "We need to have more antivirals for influenza," according to Kawaoka, "and as these...Master genetic switch found for chronic pain
...target their wiring--"form a genetic basis for the assembly of specific neural circuits for nociceptive information processing. "Finally, the identification of a core transcriptional control program for many of the ion channels and receptors known to transduce noxious stimuli has intriguing implications for t...Clawed frog helps Fanconi anemia research make leaps
... called geminin to the extract, which prevents the assembly of protein complexes essential to the beginning st...entist in Hoatlin's lab, is examining the order of assembly of Fanconi proteins on DNA and how the Fanconi proteins are activated in response to DNA damage. "W...Rutgers researchers create tiny chemical cages to enclose drug, pesticide molecules
...new, we've created new components and advanced the assembly process to increase the chance that they'll become practical," said Ralf Warmuth, associate professor of chemistry and chemical biology at Rutgers and lead researcher. "We've shown a way to securely link molecules together in a cage using an efficien...Academy honors 15 for major contributions to science
... was chosen "for her pioneering discoveries in the assembly of metalloenzymes and the regulated biogenesis of major complexes of the photosynthetic apparatus in green algae." The medal was established by a bequest of Helen P. Smith in memory of her husband and has been presented since 1979. J. LAWRENCE SMIT...The giant protein titin helps build muscles
...ups will now look for other examples. The terminal assembly complex investigated in this work, though, only covers a tiny part of the giant muscle protein titin, which possesses tens of thousands of amino acids in some isoforms. "There are probably hundreds or even thousands of more interactions down the road...Carnegie Mellon U. scientist receives NSF funding to build innovative mass spectrometer
...rotein particles. Woolford's lab is unraveling the assembly pathway of ribosomes, cellular components that make proteins. Ribosome assembly involves hundreds of proteins and intermediate protein complexes. Bier will also acquire samples fro...Recycling of aeronautics components
...the reduction in the number of parts needed in its assembly (fewer zones for riveting) and, finally, the reduction of maintenance operations over the useful lifespan of the craft. But there are certain limitations in their use such as the high costs of the raw material and of labour for the manufacture of lar...University of Alberta researcher unveils world's largest drug database
...act that the data were mostly paper-bound made the assembly of DrugBank both difficult and time-consuming. More than a dozen textbooks, several hundred journal articles, nearly 30 different electronic databases and at least 20 in-house or web-based programs were individually searched, accessed, compared, writ...SLU researchers uncover direct evidence on how HIV invades healthy cells
... studies of the effects of drugs in the process of assembly and disassembly of the viral DNA integrase complexes," Bera said.......ment of the heart tube cells is critical for heart assembly and proper shape, or morphology. The researchers found that mutation or misexpression of these proteins leads to misalignment of the heart tube and results in observed heart defects. "Although there is much interest in the understanding of the bas......l of Medicine) report on the pathway of human RISC assembly from pre-microRNAs (miRNAs), highlighting important differences from the siRNA-fueled RISC assembly pathway in Drosophila. The authors identified a protein complex between Dicer and Argo2 the "microR...Bacteria that cause tooth decay able to survive without important biochemical pathway
...ism by which proteins are chaperoned from cellular assembly lines, where they are made, to the protective outer surface of the cells, where they are inserted. Without a steady infusion of proteins, the membrane weakens and the cell - in this case, a bacterium - becomes unable to protect itself from harsh envi...