Key mechanism in genetic inheritance during cell division identified
...ngly facilitates the oligomerization process, ring assembly seems to be an intrinsic property of the Dam1 complex, as we have been able to induce self-assembly into rings in the absence of microtubules." The formation of rings around the microtubules by the purified Dam1 complex that the Berkeley collaborator...How do cells travel through our bodies?
... shape. Cells carefully regulate the breakdown and assembly of actin fibers because if they are cast off at the wrong time and place, for example in a tumor, cancerous cells may spread throughout the body and form metastases. It was already known that n-cofilin can break down actin fibers in the test tube, b...Timing is everything: First step in protein building revealed
...1, a step necessary to let it continue reading the assembly instructions. Even though yeast are the most primitive relatives of humans, the protein-building machinery, or ribosomes, of each are quite similar. "The idea is to really know at the molecular level how life is put together," says Jon Lorsch, Ph.D.,...DNA molecules used to assemble nanoparticles
...f-concept experiment," Choi said. But now that the assembly system has been worked out, other forms of dendrimer clusters are in the works. "If you wanted to make a therapeutic that targeted five drugs to five different cells, it would be 25 synthesis steps the traditional way," Baker said. At two to three ...Scientists find common roots for thousands of plant compounds
...ss can be likened to a manufacturing plant with an assembly line that makes a car part, such as a steering wheel. Some of those steering wheels remain on-site to be added to cars manufactured at that plant. Additional steering wheels are transported to another plant that, instead of making its own steering wh...The Louis-Jeantet-Prize for Medicine 2005
...l GTPases known as Rho and Rac, locally modify the assembly of the cytoskeleton and thereby control both cell-cell adhesion and cell migration. Since tumour invasion requires an inhibition of cell-cell adhesion and an increase of the cell's migratory activity, Alan Hall's work is of great importance for the u...Fox Chase Cancer Center scientists discover key proteins linked to aging and cancer
...n, age. The findings focus on the composition and assembly of key chromosomal protein complexes involved in shutting down reproduction of aging cells. The report by molecular and cell biologist Peter D. Adams, Ph.D. and his colleagues appears in the January 2005 issue of Developmental Cell. "In the lab, agi...MIT team aims to mend broken hearts
... out, electrical stimulation was crucial for rapid assembly of functional tissue," said Milica Radisic, MIT PhD 2004, who will be joining the faculty of the University of Toronto next year. After only eight days of cultivation, single cells grew into a tissue "with a remarkable level of structural and functio...Chicken genomic sequence yields insight into vertebrate evolution
...of vertebrate evolution. The whole genome sequence assembly of the Red Jungle Fowl (Gallus gallus), the ancestor of domestic chickens, has been publicly available since March, 2004, when it was initially deposited into the GenBank database for use by researchers around the world ( www.ncbi.nlm.nih.gov/genome/...Spider silks, the ecological materials of tomorrow?
...d what mechanical properties result from different assembly processes could allow the manufacture of artificial spider silks with special characteristics such as great strength or biochemical activity. "The future objective might not be to prepare identical copies of natural silk fibers, but rather to capture...Identifying the path to infection
...configuration might be necessary to coordinate the assembly and secretion of the adhesive. This is consistent with other membrane proteins that perform similar functions. "Our finding provides new insight into how the adhesive protein is assembled and secreted, but we need to know more about this proces...Crucial evolutionary link points to origins of modern cells
...hree-dimensional structure of this large molecular assembly in its entirety. For the PLoS Biology paper, Rout and colleagues focused on a group of seven proteins that form the Nup84 complex in the yeast NPC. NPCs are uniformly located throughout the membrane that bounds the nucleus of a eukaryotic cell...Mail-order drugs exposed to extreme heat become less effective
...EST 2004, the 70th annual international scientific assembly of the American College of Chest Physicians (ACCP), formoterol, a common inhaled asthma medication, delivered less than half of its expected dosage and showed significant physical changes after being exposed to 150F for 4 hours. "Inhaled medications ...Bovine genome sequence available
...ses in the next several months. Sequencing and assembly of the bovine genome began in December 2003, led b...tion and to model human disease. The initial assembly is based on 3.3-fold coverage of the bovine genome and by 2005, a 6-fold sequence coverage will be a......g Center in Houston carried out the sequencing and assembly of the genome. Additional work aimed at uncovering... Columbia Cancer Agency in Vancouver. The initial assembly is based on 3.3-fold coverage of the bovine genome. Researchers can access the sequence data through......ree-standing single-wall carbon nanotube electrode assembly containing an immobilized noble-metal catalyst to enable compact proton exchange membrane fuel cells with superior performance and longer lifetimes while simplifying manufacturing. Corning Incorporated (Corning, N.Y.) Scalable Planar Solid-Oxi...