JCI table of contents: April 12, 2007
...nt tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated AUTHOR CONTACT: Alan D. D'Andrea Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. Phone: (617) 632-2112; Fax: (617) 632-5757; E-mail: alan_dandrea@dfci.harvard.edu . View the PDF of this art...Scientists discover role of enzyme in DNA repair
...rtant discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the bodys ability to repair damaged DNA. NIAMS and NCI are part of the National Institutes of Health (NIH). When DNA within a cell is damaged, the cells protective mechanism must do one of two things: repair ......ut non-curable cancer-predisposed human disorders: ataxia telangiectasia, ataxia telangiectasia-like disorder, and Nijmegen breakage syndrome. The proteins whose deficiency is re...