Tag: "atherosclerotic" at biology news
WPI professor to represent American Mathematical Society at exhibition on science funding
...g of the growth, progression, and rupture of human atherosclerotic
plaque. Plaque is a medical condition closely related to most forms of cardiovascular diseases, the leading cause of death in the developed world. Tang's research is aimed at developing diagnostic tools that physicians can use to determine which arte...
Combining molecular imaging technologies to stop/prevent heart attacks
...way to determine the amount of inflammation within atherosclerotic
plaque and the chances of plaque causing a future ...ase. "This work features the enhanced imaging of atherosclerotic
plaquesusing a novel combination of technologies," said Josef Machac, SNM's Scientific Program Commi...
JCI table of contents -- June 1, 2007
...nst risks of thickened and hardened arteries In atherosclerotic
cardiovascular disease, arteries thicken and harden to such a severe degree that they may become clogged, causing the formation of a clot (thrombosis). The protein thrombin is a known trigger of thrombosis and researchers have wondered whether thromb...
Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism
...ble of the initial vascular lesions typical of the atherosclerotic
process. The mechanism involved in the vascular le... for proteins involved in different aspects of the atherosclerotic
process (lipid metabolism, inflammation, adhesion molecules, etc.). For the first time, the study sh...
Spotlight on liver disease: Improving today's treatments
...However, the direct influence of NAFLD on coronary atherosclerotic
disease (CAD, plaque build up in arteries) has not...ated ALT/AST ratio in women could predict coronary atherosclerotic
disease that is independent of the metabolic syndrome and serum C-reactive protein concentration," s...
JCI table of contents: February 15, 2006
...d vessel. One factor that determines how easily an atherosclerotic
plaque forms is the shear stress that the blood fl...pression pattern influences the development of the atherosclerotic
plaque. LSS was shown to induce the production of more IP-10, GRO-alpha, and fractalkine than OSS, w...
JCI table of contents: January 2, 2007
...olved in the body's response to the development of atherosclerotic
plaques a build-up of cholesterol and fatty mater... monocytes give rise to the macrophages present in atherosclerotic
plaques; (ii) there is differential expression of chemokine receptors on the surface of these cell s...
Two drugs may stabilize plaques in atherosclerosis
...tigating for lupus for several years may stabilize atherosclerotic
plaque in the walls of arteries and help avert hea...ood cell. These inflammatory proteins can make the atherosclerotic
plaque unstable. Mishra said. The macrophages were taken from normal mice and the experiments were d...
Malaria drug may treat metabolic syndrome's many symptoms
...t the cumulative contribution of its components to atherosclerotic
risk, the researchers said. An alternative view is that atherosclerosis, insulin resistance, and the component clinical features of the metabolic syndrome share a common unifying mechanism, they added. Evidence hinting at a unified mechanism came a ...
Link identified between age, cardiovascular disease
...in healthy vessels. If the vessels are narrowed by atherosclerotic
lesions the problem is further exacerbated. High blood pressure is often the result, which in turn can lead to heart attacks, strokes, and death. Some of the most common high blood pressure medications, in fact, function by helping to address this lo...
Computing catches up with theory
...ots, whether they result from blood vessel injury, atherosclerotic
plaque or an artificial medical device....
Orange juice beverage fortified with plant sterols lowers indicators of heart disease risk
...als. For example, C-reactive protein is present in atherosclerotic
lesions, and some studies suggest it may actively ...ontribute to the progression and/or instability of atherosclerotic
plaques. The American Heart Association and Centers for Disease Control and Prevention now recommend...
Nanotechnology enables low-dose treatment of atherosclerotic plaques
... inhibit the growth of new blood vessels that feed atherosclerotic
plaques -- was sent directly to the base of plaque...of fumagillin, concentrating it at the site of the atherosclerotic
plaque. In this study, the single dosage of fumagillin each rabbit received was 50,000 times lower ...
JCI table of contents: July 20, 2006
...mall face and jaw, pinched nose, osteoporosis, and atherosclerotic
vascular disease. Currently, there are less than 50 known cases of HGPS in the world and most progeria patients die at around 13 years of age. HGPS is caused by a mutation in the Lamin A gene (LMNA) that results in the synthesis of a mutant prelamin ...
Understanding of cell protection mechanism points to therapies to prevent heart attacks and strokes
...d use gene therapy to deliver the HO-1 gene to the atherosclerotic
plaques," says Dr. Melo. "Our laboratory is actively pursuing the development and preclinical testing of these new gene therapies using sophisticated viral vector systems, which are highly responsive to the pathological conditions of the plaque its...
Beyond lipids: understanding the mechanics of atherosclerosis
...anges in blood vessel cells that could explain why atherosclerotic
lesions form preferentially at branches of coronar...ches to treatment. "We've known for decades that atherosclerotic
lesions develop preferentially at vessel branches rather than along unbranched vessels, but we've no...
ACS News Service weekly press package - May 30, 2006
... compounds called "atheronals" that are present in atherosclerotic
plaques removed from patients with blood vessel di...of processes regarded as critical for formation of atherosclerotic
plaques, they found. The Biochemistry report raises the possibility that atheronals may originate in...
Targeted drug delivery now possible with 'pHLIP' peptide
...such as tumors, infarcts, stroke-afflicted tissue, atherosclerotic
lesions, sites of inflammation or infection, or damaged tissue resulting from trauma." Normal cells are surrounded by an environment with a constant pH of about 7.4, while tumor cells and sites of inflammation actively pump protons out and create an...
New testing method developed to assess safety, health risks of nanomaterials
...rticles, this injury can translate into asthma and atherosclerotic
heart disease. Using this model, Nel's laboratory has developed a series of tests to assess nanoparticle toxicity in non-biological environments as well as in tissue cultures and animal models. "We can use the strong scientific foundatio...
JCI table of contents: December 22, 2005
...roteinase-9 (MMP-9) in the macrophages of advanced atherosclerotic
lesions in mice. The authors found that macrophages secreting an autoactivating form of MMP-9 enhanced elastin breakdown in the surrounding extracellular matrix that physically stabilizes the plaque, and consequently induced plaque rupture. MMP-9 and...