Tag: "atrophy" at biology news

Mitochondria findings may help beat wide range of disease

...ells die, resulting in diseases ranging from optic atrophy (the most common inherited form of blindness), to Charcot-Marie-Tooth disease (a disease in which nerves in the hands, feet and lower legs die off), to Parkinson's and Alzheimer's diseases (which arise from neurodegenerative cell death), and evento s...

Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases

... activation is sufficient to cause skeletal muscle atrophy in vivo and that blockage of the NF-kB pathway can ameliorate atrophy suggests a new set of drug targets for chemical intervention during cachexia, cancer, AIDS and other...

Early life stress can inhibit development of brain-cell communication zones, UCI study finds

...ups have found that chronic stress causes dendrite atrophy in adults, but it is not known if CRH plays a role. Yuncai Chen, Roland A. Bender, Kristen L. Brunson and Jrn K. Pomper from the Baram group at UCI collaborated with Dimitri E. Grigoriadis of Neurocrine and Wolfgang Wurst of the Max Planck Institute...

Study demonstrates Cenestin reduces sleep disturbances/night sweats in post-menopausal women

...t flashes and night sweats) and vulvar and vaginal atrophy (vaginal itching and dryness) associated with menopause. The pilot study enrolled 19 post-menopausal females between 45 and 60 years of age who experienced an average of two incidences of night sweats and/or hot flashes per night. The wome...

Muscle loss from space travel, prolonged inactivity linked to two genes

...to identify therapeutics that could inhibit muscle atrophy caused by a chronic reduction in muscle use. Such...y. Our ongoing research shows that the process of atrophy might be partially moderated by something as straightforward as aspirin or other non-steroidal anti-...

Columbia researchers identify drug as therapeutic candidate for spinal muscular atrophy

...a protein lacking in patients with spinal muscular atrophy (SMA), a fatal pediatric genetic disease. It is the scientists' hope that the discovery will lead to additional developments and even a treatment for SMA, a neurodegenerative disease that is the leading genetic killer of children younger than 2 i...

JCI table of contents, December 15 2004

...12/1774 . Gene therapy improves spinal muscular atrophy in mice Spinal muscular atrophy is one of the most common genetic diseases leading to death in childhood. Characterized by muscle we...

Gene with broad role also causes prevalent, inherited nerve disorder

...dependent. The underlying defect in CMT is muscle atrophy due to a lack of stimulation from the nerves. That lack of stimulation stems from one of two underlying causes, which define the two primary forms of the disease: CMT type 1 and 2. In CMT type 1, the speed of the nerve impulse slows due to degradati...

Highlights of chemical society national meeting in San Diego, March 13-17

...he human body, including bone density loss, muscle atrophy and immune system stress. Now, NASA scientists have developed a new analytical system that will allow them to explore the effects of space on gene expression in microorganisms, which could lead to new ways to prevent and treat the potentially debilit...

Chronic inflammation caused by too little stomach acid leads to gastric cancer

...cess begins with chronic gastritis, which leads to atrophy of the stomach lining, followed by abnormal tissue changes and, finally, the development of malignant cells. "Now we have a mouse model that we can use to isolate the different genetic steps in human gastric cancer," Merchant says. "We've identified ...

Applied NeuroSolutions biomarker may predict Alzheimer's disease progression

...tic assay, shows great promise in predicting brain atrophy in patients with Alzheimer's disease, according to...levels may be used to predict progression of brain atrophy in AD patients. In the study of 22 Alzheimer's disease patients, all underwent Magnetic Resonance Im...

U of MN researchers reverse memory loss in mice

...d memory loss that worsens over time and had brain atrophy similar to what a person with Alzheimer's disease goes through. The researchers further designed the mice so that the transgene that causes these symptoms could be "turned off." Transgenes are genes from one organism that have been incorporated int...

Big differences in duplicated DNA distinguish chimp and human genomes

...an developmental disorders such as spinal muscular atrophy and Prader-Willi syndrome. Parts of those duplicated segments have only single copies in the chimp genome, and it is possible that the chimpanzee is therefore not predisposed to the same diseases as a human. About two-thirds of human-only duplication...

A Jekyll-and-Hyde enzyme's role in Alzheimer's

...es showed that these mice showed significant brain atrophy and loss of hippocampal neurons. The researchers also showed that the two-week pulse of p25 did not cause neurodegeneration and had long-lasting effects on enhancing memory. Studies of electrophysiological activity in the brains of the mice showed th...

Link discovered between depression and changes in the brain in Alzheimer's disease

...ry-related temporal lobes. MDD is likely to caused atrophy of the hippocampus, the area where the largest amounts of plaques and tangles form in patients with AD, the authors write. To assess how MDD might affect the development of AD, Michael A. Rapp, MD, PhD and colleagues at the Alzheimer's Disease Resea...

'Smart' genetic therapy helps the body to heal itself

...loping therapies for patients with spinal muscular atrophy (SMA). This is a relatively common inherited dis...e spinal cord patients develop muscle weakness and atrophy of the legs, arms and trunk. In patients with SMA the survival motor neuron genes (SMN1) is deleted,...

Purdue researchers find 'switch' for skeletal-muscle atrophy

...rug-treatment methods to arrest the type of muscle atrophy often caused by muscle disuse, as well as aging an...Pond said. "In addition, muscle weakness caused by atrophy during aging can lead to serious falls and bone loss. Exercise is the most beneficial strategy to tr...

A sweet solution for Alzheimer's disease?

...ry tangles. The brain becomes inflamed and neurons atrophy and die. It's not completely clear what kind of amyloid peptide (monomers, oligomeric aggregates, or fibrillar aggregates) is responsible for the onset of disease, said St George-Hyslop of the University of Toronto. "Because we were able to show tha...

Injection may prevent infertility in men receiving cancer chemotherapy

...of the testes of Taxol-injected mice showed severe atrophy and empty seminiferous tubules, where the sperm-producing cells are contained", said Mr. Carmely. "In contrast, we saw only minimal testicular damage in the group that had previously been injected with AS101, and we could also find mature sperm. Inj...

Epilepsy drug eases symptoms of inherited disorder that weakens muscles

...rug valproate to treat seven adult spinal muscular atrophy (SMA) patients. Clinicians offered the drug to patients on the basis of research conducted elsewhere that showed the drug increased levels of a key protein in cell cultures. "The treatment has been fairly successful," says lead author Chris Weihl, M....

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