NHGRI seeks next generation of sequencing technologies
... The researchers will also develop a unique way to attach many thousands of DNA molecules site specifically to a surface to produce a high-throughput device for DNA sequencing by synthesis. Peter Williams, Ph.D., Arizona State University, Tempe $1.7 million (3 years) "Multiplexed Reactive Sequencing of DNA"...Molecule that helps DNA replicate may make good target for cancer therapy
...und. Next, multiple molecules of a certain protein attach to the strands to keep them from spontaneously sti...the specific sites on the DNA strands where it can attach and go to work. "The big question was, How is polymerase alpha recruited to the first site?" said Bi...Trojan-horse therapy blocks buildup of Alzheimer's plaque
...ed a series of small "linker" molecules that would attach to a molecule called FKBP, a family of chaperone proteins found naturally at high concentrations in the cell. Gestwicki attached the other end of the linker to a molecule called Congo red, which is known to selectively bind to A peptide. In test-tube...Research to explore revolutionary gene sequencing: Threading the molecular needle
...ide of the rings, Lindsay's technology proposes to attach the ring to the sensitive AFM tip, which would thread an anchored DNA molecule into the ring and pull it through, recording the subtle differences in the "bumps" resulting from the friction of the different DNA bases with the ring. The resulting da...... with SLPI to block annexin 2, the virus can still attach to the cell, but it hits a roadblock before it can begin to replicate itself. The block probably occurs, according to Wahl, at the membrane-fusion step that is required for the virus to deliver its genetic material into the cell. While more studies...JCI table of contents, November 15 2004
...Desmogleins, a family of proteins that function to attach one cell to its neighbor, when attacked by autoantobodies, become separated from each other causing burn-like lesions or blisters that do not heal. To date, four types of desmogleins have been described Dsg14 and in the November 15 issue of the Jou...Purdue researchers align nanotubes to improve artificial joints
...ies of experiments that bone cells in Petri dishes attach better to materials that possess smaller surface b...one-third more bone-forming cells, or osteoblasts, attach to carbon nanotubes that possess surface bumps about as wide as 100 nanometers, or billionths of a m...Isotron licenses ORNL cancer treatment technology
...m-252 sources for neutron brachytherapy and how to attach them to small-diameter wires. The work was performed in ORNL's Californium User Facility. "This is a perfect example of how collaborations between ORNL and the private sector can result in technology to make our lives better," said Alex Fischer...New study discovers why 'persister' cells never say die
...e out the infection." Biofilm infections, which attach to a surface while encased in a membrane, typically attack surgically implanted medical devices, such as mechanical heart valves or artificial joints. They can also take the form of periodontal disease, ear infections or fatal lung infections. The ...New weapon in germ warfare: 'Jamming' bacteria signals stops cholera
...ind is present and then change their behaviour and attach themselves to a surface on a host or in the environment. The seaweed, a red algal species found at a UNSW marine research site in Sydney's Botany Bay, produces the compounds to prevent bacteria from forming biofilms on its leaves. ...Laser scalpel opens way for nerve regeneration studies in worms
...ing on how fast the proximal end regrows, it might attach to the distal end. Otherwise, the distal end seems to deteriorate, and the nerve regeneration will proceed from the proximal end. However, we will need to do more detailed studies to determine whether regeneration is of the two cut axons, or due to a...Solving the mechanism of Rett Syndrome
... might cause Rett Syndrome was that, by failing to attach to methylated CpG dinucleotides, it would fail to repress inappropriate gene expression in the brain," says Kohwi-Shigematsu. For some genes, called imprinted genes, their expression status depends on whether the gene came from the materna...Scientists find impaired chromatin structure formation & imprinted gene involvement in Rett Syndrome
...in is not produced in a given cell, methyl groups attach to CpG dinucleotides, which are often clustered in areas of the gene called CpG islands. MECP2 then binds to these methylated CpG sites, shutting down the gene's production of its protein. Faulty over-expression of target genes caused by mutated Me...Needling chromosomes yields insights into cell division
... to be held together, because otherwise they don't attach to the apparatus called the spindle that distribut...e held together, then one replicated chromatid can attach to one pole and the other to the opposite pole. But if they are not held together, they attach indep...The Louis-Jeantet-Prize for Medicine 2005
... polarity and to organize cell-cell junctions that attach them firmly to neighbouring cells so that they form a cell layer. The cytoskeleton is also profoundly rearranged when cells migrate. Alan Hall receives the Louis-Jeantet Prize for his discovery that specific enzymes, small GTPases known as Rho and Ra...Erkki Ruoslahti of The Burnham Institute named recipient of 2005 Japan Prize
...nd molecular definition of the site at which cells attach to one another, the peptide RGD. Dr. Ruoslahti's discoveries in cancer biology are also relevant to a broad range of cell behaviors, which are involved in managing heart attack, stroke, osteoporosis, and angiogenesis. Dr. Ruoslahti earned his M....Deciphering the genetic babel of brain cells
...uorescent indicators, genes from the cell extracts attach to their complementary counterparts on the chips. Measurements of the fluorescence of each spot give scientists an indication of the activity of particular genes. As vital as they are to studies of individual types of cells, gene chips have proven to...Researchers find local environment directly influences adult stem cell reservoirs
...tromal cells, the non-stem cells that surround and attach to stem cells, release signals that are received and processed by stem cells and the daughters remaining in the niche. These molecular signals block certain genes from becoming active in the remaining stem cell daughters, preventing them from becom...Progress toward a new remedy for chronic urinary tract infections?
...investigated the way in which the E. coli bacteria attach themselves. This attachment takes place by means of a reaction between the protein 'Adhesine FimH' on the tips of the pili and special receptors on the wall of the urinary tract. The researchers hypothesized that they could prevent this binding by ad......which ordinarily infects T-cells, to hunt down and attach to P-glycoproteins -- molecules located on the surface of many cancer cells. The UCLA team is the first to prove that modified HIV will target and bind with P-glycoproteins. "P-glycoproteins cause big problems by making the cell resistant to che...