Scientists discover that three molecules may be developed into new Alzheimer's drugs
...said Kosik. "This means that many phosphate groups attach to tau--modify it--and cause it to become dysfunctional." The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, facilitating the disease process. The researchers set out to find a way to inhibit this enzyme, to keep...Alzheimer's disease; new approach, new possibilities?
...us mouse models, they demonstrate that the plaques attach primarily onto the blood vessels. The vessels show clear structural damage, so that the strictly-controlled separation between blood vessels and brain is compromised and leakage occurs. A new model as a first step towards a treatment? Under normal...Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue
...teresting ways we can do this. For example, we can attach an antibody to a carbon nanotube to target a particular kind of cancer cell." One example is lymphoma, or cancer of the lymphatic system. Like many cancers, lymphoma cells have well-defined surface receptors that recognize unique antibodies. When att...Enzyme action creates protein linked to Alzheimer's disease
... nicastrin from latching on to APP. If APP doesn't attach to nicastrin, APP remains intact and harmless. Meanwhile, nicastrin would be free to bind all the other essential proteins that it works on. "We want to find a particular way to block the recognition of APP but not the others," Dr. Yu said....Gene therapy advance treats hemophilia in mouse models
...ified virus. This hybrid vehicle could more easily attach to certain liver cells and allow the genes within the vehicle to enter the cells. The genes then caused the liver cells to make the protein that prevents bleeding. The researchers also modified the vehicle so that it would express these therapeutic ...Nitric oxide could extend fertility
...ity of ooplasmic microtubules (the structures that attach to chromosomes and guide them to different parts of a cell during division), increase the release of cortical granules (the molecules responsible for preventing egg fertilization by more than one sperm) and delay other signs of aging. In addition t...Immune system has evolved to prevent autoimmune disease
...es, or epitopes, where antibodies could mistakenly attach themselves to proteins in a healthy cell. The mutation response method employed by our adaptive immune system seems keyed to this number, producing antibodies that are statistically likely to mistakenly bond with healthy proteins slightly less than o...Clearing jams in copy machinery
...acles encountered in the replication process. They attach themselves at the same time to one beta sliding clamp. Pol III copies the original DNA, and acts as a proofreader to catch any misspellings and cuts any base that is wrong. But Pol III is a perfectionist, and can stall if it encounters a problem. Pol...Secrets to antibody's success against West Nile Virus surprise scientists
...ctations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops...o find that the antibody only seemed to be able to attach to 120 of the 180 copies of the target region in the complete viral envelope," says Grant Nybakken, ...New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
...hemagglutinin surface protein that helps the virus attach to cells and replicate properly. This gene seemed to be responsible for much of the severe lung damage reported in people infected with the Spanish flu. The three genes encoding the viral "polymerase" enzymes, which form the virus' basic replication ......e used. During this cut-and-paste operation, cells attach a group of molecules called the exon junction complex (EJC) to the RNA. An RNA made from a mutant gene usually has an EJC in the wrong position, which activates NMD and destroys the RNA before it can be used to make flawed proteins. Andreas Kulozik a...Geologists use biotools to understand geosystems
...wing through the soil, are those bacteria going to attach to a mineral surface or are they going to reach your well? Virginia Tech researchers are looking at the mobility of bacteria and of heavy metals in surface and ground water. Geosciences professor Michael Hochella Jr. will present recent findings at ...Electrical engineer works on personalizing medical treatment
...sample of a cancer patient. The RNA molecules then attach to their corresponding DNA genes. The more RNA segments that attach to a gene, the more that gene will glow or fluoresce, which is called gene expression. The expressio...Study finds protein is required for human chromosome production
...reaction, Dominski had enough time to irreversibly attach the RNA cutting protein, or nuclease, to the RNA itself using ultraviolet light as a cross-linking agent. Once attached to the RNA, the long-sought-after nuclease was trapped, allowing its subsequent identification. The discovery that the RNA cutting...Nanoparticle created as diagnostic, therapeutic agent; brain tumors targeted
...e. Gibson has since created a multitude of ways to attach guest molecules to the fullerene host, so the fMFs can attach to disease sites in a variety of ways, perhaps as photodynamic therapy agents. Preliminary experimen...Researchers learn how blood vessel cells cope with their pressure-packed job
...e to the membranes in a manner similar to how they attach to underlying blood vessel tissue in the body. The... of adhesion sites where those stress fibers would attach to the cell membrane."These new results clearly show that Rho and physical stresses cooperate to pro...Gene variants predict heart muscle damage after cardiac surgery
... or other injury. ICAM-1 allows the white cells to attach to the inner lining of the blood vessels where they inflict damage. LBP regulates the body's response to bacteria normally living in the gastrointestinal tract that can release endotoxins into the bloodstream as a result of the action of the heart-lu...Battle to beat the bugs wins bio-firm top honour
...e been shown to attack the HIV virus before it can attach itself to the cell and so, in theory, could kill off the virus completely. "This way of fighting viruses outside the cell has been overlooked in the past and so a lot more research is needed. "Whether antiviral drugs will provide a cure on their own ...Figuring out the ups and downsand sidewaysof neural development
...rpendicular to the neuroepithelium. These spindles attach to the dividing chromosomes in the nucleus and drag the two copies apart, ensuring that each daughter cell has its fair share. In an article in the November 23, 2005, issue of Neuron, Mihaela igman and colleagues have pinpointed a key regulator of sp......s require a source for the methyl groups that they attach to DNA, and most often that source is a molecule c...masauskas and colleagues wanted the flexibility to attach more than just a simple methyl group. In this study, the scientists demonstrated that methyltransfer...