Bacteria research offers hope for new vaccine against meningococci
...ia cells use to adhere to the receptors) could not attach to mucous linings. Thanks to the new system the research team has developed, it is now possible to rapidly and effectively monitor the function of various vaccine candidates and new drugs, obviating the numerous costly and time-consuming tests that...Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
...g system works by producing proteins that directly attach to the cell-division genes, hindering their activity. Yet another protein they identified works, instead, by dismantling messenger RNA carrying instructions for making cell division proteins from the genes to the cell's protein-production machinery. ...Scientists expand microbe 'gene language'
... with their hosts. For example, all must initially attach to the host. PAMGO, from the beginning, tailored the new terms so they would be useful for describing both benign and pathogenic microbes in plant or animal hosts. "Having a common set of terms to describe genes of pathogenic and beneficial microbe...Bacterial walls come tumbling down
...mily of enzymes that remove sugars from lipids and attach them to other sugars. This process is used in a wide range of biochemical reactions, including allergic responses and cell signaling in cancer....Notorious cancer gene may work by destroying messenger
...boratory, wanted to learn how PMR1 is activated to attach to mRNAs. They found that activation occurs when PMR1 is momentarily joined by an unidentified enzyme. Contact with this enzyme changes the properties of PMR1, and this enables it to join with, or bind to, its target mRNA. Peng then used monocl...MIT biologists solve vitamin puzzle
... don't require B12 to survive, and the plants they attach themselves to don't need it either, so he speculates that synthesizing B12 may enable the bacteria to withstand "challenges" made by the plants during the formation of the symbiotic relationship. More than 30 genes are involved in vitamin B12 synth...Targeting tumors the natural way
...iving systems instead involves binding agents that attach only weakly to any single target receptor, and thus stick to cells only when several receptors are displayed together. These weak "multivalent" interactions cut down on cases of mistaken identity, because if the agent contacts the wrong cell type, it...DNA layer reduces risk of reserve parts being rejected
...ting. A method therefore had to be found to firmly attach the DNA to the implant surface. Van den Beucken used the Layer-by-Layer deposition technique (see Figure 1) to produce a multilayer coating. This coating was tested in cell cultures and animal experiments for its safety, immune response, bone attachm......hey have nearly identical modes of action and even attach to the same receptor on the cell wall. However, interferon gamma is different. It has its own receptor and, in addition to its immediate antiviral actions, is involved in a number of crucial activities in the immune system, including a step known as ...Widely used iron nanoparticles exhibit toxic effects on neuronal cells
...tly to a tumor. Magnetic nanoparticles designed to attach to cancerous tissue can also be made to heat up by using a remote, alternating magnetic field, thereby selectively killing cancer cells in a process called magnetic hyperthermia. Many researchers throughout the world are also studying the use of i...Switching genes to overdrive improves muscular dystrophy symptoms in mice
...nctions (NMJ) sites on muscle fibers where nerves attach and signal the fibers to contract. Part of the reason that exercise builds stronger muscles is that it increases PGC-1alpha activity. Conversely, disease or lack of exercise reduces PGC-1alpha activity, causing a loss of NMJ function and weakening, o...Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
...ontent/full/2007/8/pdb.prot4738 ) describes how to attach a small tag, called GST (glutathione- S -transferase), to a specific protein of interest. This is accomplished by growing bacteria that contain the DNA sequence for the GST tag adjacent to the gene for the protein of interest. When the bacteria grow,...Plastic with changeable conductivity developed by chemical engineer
... far, they have learned that the higher mass acids attach to the plastic in longer chains, and induce a less-ordered internal structure (crystallinity) within the plastic. Understanding how the structure of this polyaniline material changes when its conductivity changes will be crucial for selecting the ...Little lifesavers -- Nanoparticles improve delivery of medicines and diagnostics
...echniques for improving drug delivery, which is to attach molecules to drugs to make them more water soluble. "Our advance is to use this technique and turn it around so the drugs stay inside our particles until we want them to leave," he said. Beyond using size alone to target cancer cells, the team is w...Weizmann Institute scientists discover a key player in embryonic muscle development
... by an external signal once myoblasts identify and attach to each other. Only when it receives this signal does WIP hook the actin fibers in the skeleton up to the myoblast recognition protein, allowing cell fusion to proceed. The WIP protein has been conserved evolutionarily. In other words, versions of ...Cheaper, better disease treatments expected from faster approach to developing antibodies
...ges result in slightly altered antibodies that may attach more strongly to a disease protein. The interactio...ab, to identify the bacteria-bound antibodies that attach best to the PA. Van Blarcom then took those bacteria and grew large numbers of them to begin refinin...Award lectures for ASBMB's 2007 Annual Meeting
...ther through small molecules called coenzymes that attach to the enzymes' surfaces, but quino-enzymes display coenzymes inside their structure. Klinman will describe some of the unexpected features of these quino-enzymes. MONDAY, APRIL 30 Fritz Lipmann Lectureship - 8:30 a.m.-9:30 a.m., Ballroom C "P...Krber Prize to ETH Zurich Professor Seeberger
...ttack them: cancer-producing helicobacter bacteria attach themselves to the glycans in the gastric mucous membrane; flu viruses bind to the glycans on the lungs. Vaccine to come In order to develop a carbohydrate-based vaccine, researchers must first determine which glycans are typical for the disease of ...Why do oysters choose to live where they could be eaten?
... when they get their one chance to select where to attach themselves to the bottom," said University of Maryland Center for Environmental Science Chesapeake Biological Laboratory researcher Dr. Mario Tamburri. "Our research shows that oyster larvae are willing to risk predation by adult oysters to cash in o...... K. Menon describe how a lipid that helps proteins attach to cell membranes is made. The protein, called glycosylphosphatidylinositol (GPI), is important because people with defective GPI can develop seizures, have heart attacks, and acquire a hemolytic condition in which red blood cells are destroyed. Also...