Modified mushrooms may yield human drugs
...ure." To create transgenic mushrooms, researchers attached a gene that confers resistance to hygromycin, an antibiotic, to circular pieces of bacterial DNA called plasmids, which have the ability to multiply within a bacterium known as Agrobacterium. The hygromycin resistance gene is a marker gene to hel...Targeting key proteins of carcinogenesis
...ded the cell can re-activated them by cleaving the attached Ub. In this way the cell can quickly and dynamically react on external signals. The discovery provides the basis for novel therapeutic approaches that are more specific than drugs like Bortezomib. For an effective therapeutic use there is still a ...Surprising origin of cell's internal highways
..."I've seen that there are lots of microtubules not attached to the centrosome," said Kaverina, assistant professor of Cell and Developmental Biology and senior author on the paper. "So I am trying to look at their origins." The Golgi has been suspected to function as an MTOC, explained Kaverina. However, c...Giant magnetocaloric materials could have large impact on the environment
...s, the researchers found significant magnetization attached to the germanium ions. This is surprising and important, said Argonne physicist Daniel Haskel, who led the research team. Germanium was expected to be non-magnetic. Its magnetization is induced by the hybridization, or mixing, of otherwise non-magn...Gannet population under threat from global warming
...e Northumbrian coast, using satellite transmitters attached to the birds, to gather information about their movements. Gannets have been forced to travel as far as the Norwegian coast to find food a round trip of over 1000km, said Dr Hamer. They compensate by flying faster to make sure they dont leave thei...A possible mechanistic link between stress and the development of Alzheimer tangles
...neurodegenerative conditions, phosphate groups are attached to tau. As a result, tau looses its grip on the microtubules, and starts to collapse into insoluble protein fibers, which ultimately cause cell death. Previous studies had shown that extreme physiological stress, such as plunging mice into ice wate...Bacteria ferry nanoparticles into cells for early diagnosis, treatment
...e's Birck Nanotechnology Center. The researchers attached nanoparticles to the outside of bacteria and linke...to 200 nanometers - or billionths of a meter - are attached to the bacteria with "linker molecules." "The use of commercially available polystyrene nanopartic...Blocking beta1-integrin to treat cancer
... intolymphatic blood vessels because they were not attached to anything any more. However, thecells did not elicit metastasis and were unable to form tumours they stopped growing andbecame senescent. The authors suggest that the ablation of beta1-integrin function, and the resultinginduction of cellular se...Cellular message movement captured on video
...lizing paxillin with dyes that stain cells rigidly attached to microscope slides. Those snapshots of fixed cells cant reveal paxillin movement. We can now see the dynamics of how paxillin and other proteins move inside the cell with new fluorescent labels and live-cell video microscopy, said Chien, director...Math that powers spam filters used to understand how brain learns to move our muscles
...inciple; they predict which key words are probably attached to mail you dont want and learning as they go to fine tune what they exclude from your in-box. The computer model, Shadmehr says, almost precisely duplicates the results of experiments that tested the ability of monkeys to visually track rapid fla...Some forest birds can survive in agricultural countryside with limited habitat conservation
...ntification number. Using false-eyelash glue, they attached a radio-transmitter with a battery life of one-to-three months. The team tagged and tracked a total of 156 birds during the study. "We had a Pathfinder packed with 10 people and gear," he recalled. "A couple times we had people hanging onto the out...UVa researcher studying disease that cripples newborns
...d), his team created a new kind of mouse model. It attached many added CTG repeats to the DNA of a gene that made the muscles in mice glow green under a microscope. This enabled easy observation of what occurred as the DNA converted into RNA and, subsequently, into the proteins that determine the function of ...From the deep -- Researchers find new species of sea anemone
... high-tech equipment like underwater video cameras attached to remotely operated vehicles (ROVs). Deep sea ROVs are also equipped with robotic arms and suction devices that are used to collect species. "It's like a submarine that's manned from the surface," said Daly, who plans to head to Monterey Canyon la...Researchers create model of cancer-preventing enzyme, study how it works
...o the mitochondrial membrane, not allow them to be attached to oxygen to create highly reactive superoxides. Tanner and White said they hope to continue to study proline dehydrogenase and the molecules that can inactivate it. They also plan to examine another protein they suspect works in collaboration with...Magnetic computer sensors may help study biomolecules
... biomolecules such as proteins or DNA strands were attached to the magnetic particles, the spin-valve array could apply torsional forces strong enough to alter the structure or shape of the biomolecules. The NIST group is now working on a microfluidic chip that will accomplish this electronically, which would...Vaccine prevents prion disease in mice
...ld stimulate the mice's immune system, researchers attached prion proteins to a genetically modified strain of Salmonella. For the study, the mice were orally vaccinated with a safe, attenuated Salmonella strain, which expressed the prion protein. Then they were divided into two groups those who had high ...The brain is more adept at using the nose than previously realized
...tion," Kay said. For the study, the researchers attached electrodes to the brains of four rats and trained them to distinguish different odors. The electrodes followed the oscillations of the cells in the olfactory bulbs. The oscillations act as a means to carry complex information between cells, Beshel ...News tips from the Journal of Biological Chemistry
... through a mechanism by which methyl molecules are attached to DNA. The cells of a given tissue can expres...that genes are repressed when methyl molecules are attached to them a process called methylation but such studies have not shown that all genes are repressed ...Map predicting spread of avian flu
...south, close to the German and Belgian border (see attached figure). The authors suggest local control measures are unlikely to be able to halt an unfolding epidemic in these areas. The paper, published in the Open Access journal PLoS Computational Biology, arrives at these conclusions through a computatio......hin eggs, thousands of membrane-bound vesicles are attached to the plasma membrane. Within seconds after fertilization, the contents of these vesicles are rapidly released. Previous research has shown that special proteins kept these vesicles tethered to the eggs membrane. What about the membranes? What do th...