32 new grants made for innovative technology R&D
...an be used to treat a wide range of infectious and autoimmune diseases, in cancer treatments, to address the growing threat of antibiotic resistance, and to provide potential therapeutic agents in the event of a bioterrorist attack. RheoGene, Inc. (Norristown, Pa.) Novel Technologies for Adult Stem Cell ...Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry
...e to invading microbes, it may also play a role in autoimmune diseases. Hershko has been a summer investigator at the Marine Biological Laboratory since 1991. He was drawn to the MBL when he became interested in learning more about the role that ubiquitin plays in the cell division cycle. "Many important ...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
...the efficacy of anti-cancer vaccines or preventing autoimmune diseases. Autoimmune diseases are those in which t...latory T cells prevents the destructive effects of autoimmune diseases, such as diabetes type 1, which occurs when effector T cells mount an attack on the cells o...Gene-altered mouse is model for rare autoimmune syndrome
...y Medical Center have mimicked a little-understood autoimmune disorder in humans. In the puzzling disorder, call...mises early development of T cells and produces an autoimmune response. Importantly, said Zhuang, genetic analysis can be further applied to this animal mo...Genetic data crunching achieves milestone at Stanford
...ut what the immune system attacks in patients with autoimmune diseases and to pinpoint genes involved in multiple sclerosis. Sherlock estimates the database now supports 400 campus researchers doing work on 30 different organisms (more are added as needed), and he believes it to be the world's largest academic ...JCI table of contents November 1, 2004
...ics a self antigen can accelerate but not initiate autoimmune diabetes AUTHOR CONTACT: Matthias G. von Herrath La Jolla Institute for Allergy and Immunology, 10355 Science Center Dr, San Diego, CA 92121, USA Phone: 858-558-3671; Fax: 858-558-3579; E-mail: matthias@liai.org View the PDF of this article at: ht...In a tiny squid, bacterial toxin governs organ development
...hat their influence is responsible for suppressing autoimmune disease and allergies. In contrast, there are probably no more than 100 species of bacteria that cause serious illness in humans. The implications that humans are awash in benign and beneficial microbes raises new conce...By impounding iron, FHC foils cell suicide, fuels inflammation
...ting, infection after infection, which can lead to autoimmune diseases, such as arthritis, in which left-over warrior cells that no longer have an enemy turn on the self. The researchers focused on NF-kB, a family of transcription factors -- proteins that turn on or off specific genes. The NF-kB family plays a...IRCM scientist demonstrates basic active mechanism of immune-system cells
... a study that could revolutionize the treatment of autoimmune diseases, such as juvenile diabetes, lupus, and rh...own as B lymphocytes or B cells. In subjects with autoimmune diseases, these lymphocytes, which are also normally responsible for fighting infection, are hyperac...Other highlights in the November 17 JNCI
...rr virus (EBV)-positive lymphomas in patients with autoimmune diseases by reactivating latent EBV and by the drug's immunosuppressive properties, according to a new study. EBV is a human herpesvirus that is found in more than 90% of the adult population. The virus establishes a lifelong persistent infection of ...New protein structure may aid in design of therapeutics for autoimmune disease
...these cases would disable the T cells and halt the autoimmune reaction. Currently, several PKC inhibitors are be...es, including T cell leukemias and T cell mediated autoimmune and respiratory diseases such as asthma."...Racial disparities noted in immune system genes
... include premature labor, transplant rejection and autoimmune disorders such as multiple sclerosis and scleroderma again, all more common among African Americans. Specifically, scientists compared genetic data on 179 African-American and 396 white women who sought prenatal care and delivered uncomplicated, sin...Stem cells may hold promise as multiple sclerosis cure
... Italy. Multiple sclerosis (MS) is a chronic, autoimmune disease characterized by the destruction of myelin...cells into the tail vein of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis characterized by nearly identical bra...JCI table of contents, December 1 2004
... to joint destruction. Considered by some to be an autoimmune disorder where immune complexes are formed in the ...the levels of which are augmented in patients with autoimmune and inflammatory diseases. Another proinflammatory agent, TNF-a, stimulates IL-1 expression and vice...Common lineage suggested for viruses that infect hosts from all three domains of life
...iseases, including cancer, cardiovascular disease, autoimmune disorders, and infectious diseases. Founded in 1892 as the first institution of its kind in the nation, The Wistar Institute today is a National Cancer Institute-designated Cancer Center -- one of only eight focused on basic research. Discoveries at ...Discovery about Vitamin C explains its metabolic value
...es such as heart disease, Alzheimer's disease, and autoimmune disorders. The toxic products produced by fat oxidation may not only be relevant to genetic damage and cancer, researchers believe, but are also very reactive compounds that damage proteins. For instance, there's a protein in LDL, the "bad" cholester...Gene vaccine for Alzheimer's disease shows promising results
...s also occurred in a handful of patients. Some had autoimmune responses that caused encephalitis. The key in the UT Southwestern study was finding another way to vaccinate patients without stimulating the body's own immune cytotoxic T cells, said Dr. Roger Rosenberg, a study author and director of the Alzheimer...UT Southwestern researchers locate gene family involved in determining potential for acquiring lupus
... the potential for acquiring lupus, a debilitating autoimmune disease that affects more than one million America...ases." Systemic lupus erythematosus (SLE) is an autoimmune disease causing the immune system to attack the body's own tissue and organs, including the joints, ...Genes tied to abnormal immune response in mice with lupus
... other potentially harmful foreign invaders. In an autoimmune disease, like SLE, the immune system loses its abi...a subset of SLAM/CD2 genes are associated with the autoimmune response observed in SLE mice. "Given our association of variations in the SLAM/CD2 cluster with l......s at Harvard Medical School. Crohn's Disease is an autoimmune inflammatory disorder of the gastrointestinal tract and is histologically characterized by inflammation, epithelial ulceration, fissure formation, and stenosis of segments of the entire gastrointestinal tract. The disease leads to significant morbidi...