Tag: "autoimmunity" at biology news

Antibody-altering protein found in developing B cells

... cells may offer a new direction for research into autoimmunity and other diseases. ...

JCI Table of Contents -- July 2, 2007

...ition 16 of insulin B chain) restored anti-insulin autoimmunity in mice that lacked native insulin genes. In addit...sulin B:923 for the development of anti-islet cell autoimmunity in a mouse model of type 1 diabetes. TITLE: Priming and effector dependence on insulin B:923 pepti...

Cord blood may preserve insulin levels in children with type 1 diabetes

...roviding some immunotherapy and downregulating the autoimmunity these patients have, Haller said. Realistically, we hope to protect whats left of their insulin-production for an extended period of time. We think the immune regulation hypothesis is more likely than the hypothesis that stem cells are forming insuli...

Burroughs Wellcome Fund awards $14M to support physician-scientists

...ersity of California-Davis gC399tr an inhibitor of autoimmunity Eric Matthew Morrow, M.D., Ph.D. Harvard Medical School Identification of autism genes in special founder populations using high-density SNP microarrays Christopher Newton-Cheh, M.D. Harvard Medical School Genomic dissection of QT interval du...

Minuscule molecules pack a powerful punch

...nt an effective immune response, susceptibility to autoimmunity and susceptibility to infection. "This dramatic finding reflects a large amount of work by collaborating groups," said Professor Allan Bradley, Director of the Wellcome Trust Sanger Institute. "Showing that knocking out a microRNA has such dramatic...

Link found between immune system and high plasma lipid levels

...or untoward consequences of combating pathogens or autoimmunity remains to be determined." ...

Researchers discover connection between allergic diseases and autoimmune diseases

...ly where the "relaxation" in the control of B cell autoimmunity takes place. "In association with other UW laboratories, we also have begun to study drugs that can counter some of these effects. One such drug helps to prevent autoimmune kidney disease in a related animal model," said Rawlings....

JCI table of contents -- March 1, 2007

...resent in newborn children are protective and that autoimmunity arises as a result of defects in the maturation of the immune system later in life. TITLE: Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics AUTHOR CONTACT: Irun R. Cohen Weizmann Institut...

Cells passed from mother to child during pregnancy live on and make insulin

...en in the belief that maternal cells might trigger autoimmunity in the child, has now taken an interesting new twist, for the maternal cells might even be helping the child to repair injury. In this study, published in the January 22 issue of the Proceedings of the National Academy of Sciences, Dr Kathleen Gil...

Cracking open the black box of autoimmune disease

...n human health, but on a strictly molecular level, autoimmunity is a black box," says Young. "When we discover the molecular mechanisms that drive these conditions, we can migrate from treating symptoms to developing treatments for the disease itself."...

JCI table of contents -- January 11, 2006

...g function is likely to contribute to the systemic autoimmunity from which individuals lacking WASp suffer. TITLE: Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis AUTHOR CONTACT: David J. Rawlings University of Washington School of Medicine, Seattle, Washington, USA. Phone: (206...

Regulatory T cells require WASp if they are to prevent self-destruction

...g function is likely to contribute to the systemic autoimmunity from which individuals lacking WASp suffer....

UCLA neuroscience research leads to a possible treatment for type 1 diabetes

... in a medical journal showing a connection between autoimmunity to an unknown protein in insulin-producing cells and diabetes. Kaufman surmised that this unknown protein was in fact GAD, the protein he had studied in Tobin's lab. To study the possible connection between GAD and diabetes, Kaufman again worked wi...

JCI table of contents: September 1, 2006

...ed immune responses that occur in individuals with autoimmunity and in individuals who reject a transplant. The th...34 AUTOIMMUNITY: Virus pulls the trigger for autoimmunity Autoimmune diseases are caused by cells of the immune system (in particular, B cells and T cells)...

JCI table of contents: August 1, 2006

... IMMUNOLOGY A designer approach to regulating autoimmunity in diabetes Type 1 diabetes is an autoimmune disorder in which the body's own immune system attacks the beta cells of the pancreas, destroying or damaging them sufficiently to reduce or impair insulin production. Therefore, shutting down the auto...

Efforts to replicate controversial diabetes therapy bring partial success

...stem cells, which had matured into beta cells once autoimmunity was controlled." Despite the inability of any of the three teams to replicate that aspect of the study, the authors were encouraged by their other successes. "Our studies confirm that autoimmune diabetes can be reversed," they conclude, "and that su...

Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice

...ng "cured" of their hyperglycemia as well as their autoimmunity against beta cells. However, none of the teams fou...slet recovery in the 'cured' mice is that when the autoimmunity was suppressed, beta-cell growth was permitted -- or even promoted -- exceeding death of the beta ce...

JCI table of contents, March 16, 2006

...astatin and glatiramer acetate in treatment of CNS autoimmunity AUTHOR CONTACT: Scott S. Zamvil University of California, San Francisco, California, USA Phone: (415) 502-7395; Fax: (415) 502-8512; E-mail: zamvil@ucsf.neuroimmunol.org View the PDF of this article at: https://www.the-jci.org/article.php?id...

Faulty immune-priming cells start autoimmunity

...tissues rather than foreign bodies. "We knew that autoimmunity in general can be caused when dendritic cells are ...ocytes to attack. Previously, many people thought autoimmunity occurred through apoptosis because of accumulating lymphocytes or white blood cells key elements of ...

JCI table of contents, February 16, 2006

...d T cells was able to induce complete remission of autoimmunity in mice with established disease. The researchers suggest that APRIL blockade may be better therapy for diseases caused by short-lived antibody-producing B cells. In addition, the authors state that these results have implications for the therapeutic...

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