Abnormal fat metabolism underlies heart problems in diabetic patients
... developed defects in mitochondrial function which became worse when they were fasted a condition that, like diabetes, causes the heart to use lipids for fuel. A 16-hour fast caused significant problems with the mouse hearts' ability to pump blood, again implicating altered lipid metabolism, cardiolipin sc...Climate change and permafrost thaw alter greenhouse gas emissions in northern wetlands
...ere, as previously frozen plant and animal remains became susceptible to decay. This could serve as a positive feedback to climate change, where typically warming causes changes that release more greenhouse gases, which in turn causes more warming, and more emissions, and so on, she said. But what the......d other unique wildlife species. WCS also recently became the owner of Karukinka a protected area of over half a million acres in southern Chile on Tierra del Fuego a gift of Goldman Sachs in 2004 which contains some of the worlds last remaining wilderness areas at the southernmost tip of South America.....Proteaceae spread by continental drift and transoceanic dispersal
...ge of the fossil record of the Proteaceae, that it became possible to undertake this rigorous analysis. Sometimes science is about getting the right people with the right skills together in order to make advances....News tips from the Journal of Neuroscience
... active) Pak1 peaked at the same time that neurons became polarized with distinct axons and dendrites, at ~ 2--4 d in Vitro (DIV). Total Pak1, in contrast, reached a plateau at 4 DIV and beyond. Total and activated Pak1 were evenly distributed among multiple neurites before polarization, but once a neurit...Role of thyroid hormones in slumber under investigation at Rutgers
...ed his own understanding of his condition. Once he became aware of thyroid hormones effect on the brain, he saw connections to his own life and to unsolved problems related to the role of thyroid hormones in the nervous system. Martins previous research established that in the adult brain, thyroid hormone...Study: Sticking to the sand might not be such good, clean fun for beachgoers
...low of bacteria. They found that when the dry sand became submerged by seawater during the flooding tide, en...tal Protection Agency in 1986. In 1999, California became one of the first states to mandate weekly water quality tests during peak tourist season, which runs...Pregnant mothers join search for causes of autism
...the pilot phase of MARBLES will talk about why she became involved in the study. Irva Hertz-Picciotto, an expert on how environmental chemicals affect child development and MARBLES principal investigator, will share her inspiration for launching the study, insights from the pilot phase of the study,...Immunity in social amoeba suggests ancient beginnings
...f none of the early diverging organisms that never became multicellular developed this kind of signaling system, it would subtly strengthen our argument, he said. ...Unknotting DNA clue to cancer syndrome
...nd that when SGS1 was defective, yeast chromosomes became more promiscuous in combining with each other as they attempt to repair breaks in the DNA. Normally, to repair broken DNA, matching chromosomes associate so that an intact chromosome can act as a template for the damaged one. The DNA strands are th...JCI table of contents: August 1, 2007
...igation mice lacking AMPK function in POMC neurons became obese because they reduced their energy expenditure and increased their food intake after fasting. By contrast, mice lacking AMPK function in AgRP neurons showed age-dependent decrease in body weight. Surprisingly, these effects were mediated by an i...'The Man Who Saved The Sea Turtles'
...an wildlife -- and to encounter sea turtles, which became his lifes work. From a conservation standpoint, perhaps his greatest discovery was that a beach known as Tortuguero in Costa Rica is the most important nesting site of the endangered green turtle in the entire Western Hemisphere, Davis said. In doc...Does EPA have an adequate strategy to oversee nanotechnologies?
...at EPA. He also wrote the original version of what became the Toxic Substances Control Act. What: Testimony before a public meeting on EPAs proposed Nanoscale Materials Stewardship Program When: Thursday, August 2, 2007, 9:00 a.m. 4:00 p.m. Where: Holiday Inn Rosslyn, Arlington, Virginia ...JCI table of contents -- July 26, 2007
...ells by dendritic cells was irregular and the mice became susceptible to the development of a multiple sclerosis-like autoimmune response. This is the first study demonstrating that macrophages in the marginal zone of the spleen regulate not only efficient clearance of dying cells, but also the selective en...MicroRNA works with Ago2 protein to regulate blood cell development
MicroRNAs became the stars of the RNA universe when, in 2001, scientists found that these short RNAs can control whether or not genes are expressed. This month, scientists at Rockefeller University and the Wellcome Trust cast new light on the genesis of these key bio...Scratch no more: Gene for itch sensation discovered
...n the spinal cord until now." In fact, Chen's team became interested in GRPR because they were looking for genes in the pain pathway. Among potential pain-sensing genes they identified, GRPR stood out because it is present in only a few nerve cells in the spinal cord known to relay pain and/or itch signals ...Monell researchers find metabolic defect in liver that can lead to obesity
... high-fat diet, the obesity-prone rats overate and became obese, gaining 36% more weight than resistant animals. Fat oxidation was further compromised due to a decreased ability to make CPT1A, the liver enzyme responsible for transporting fat into mitochondria. The inherited propensity to gain weight wh...New joint replacement material developed at MGH put to first clinical use
...ints were developed in the late 1960s, but it soon became apparent that hip implants could start loosening about 5 years after surgery and would eventually fail completely. A team led by William Harris, MD, DSc, now director emeritus of the MGH OBBL, investigated this complication and found that long-term f......s involved in the inflammatory and stress response became more active with age, while genes important for regulating gene expression and genomic integrity became less active. These results lend strong support to the notion that HSCs succumb to the wear and tear ......dothelial cells. When these PPAR-deficient animals became mothers, they appeared normal, but the milk they produced most certainly was not. "We were delighted and surprised by the discovery because it directly explores one of life's most common events - breast feeding. These findings will enhance the und...