Scientists honored with 'Excellence in Clinical Research Award'
...neering researchers for their work in regenerating beta cells -- which are destroyed in type 1 diabetes --...atah Pharmaceuticals to further the development of beta cell regeneration; Tony Cruz, Ph.D., Chief Executive Officer and a founder of Toronto-based Transiti...JCI table of contents -- June 1, 2007
...of amyloid plaques, made up of the peptide amyloid beta (Abeta), in brain tissue. The role, if any, of inflammation in AD remains somewhat of a mystery. Although the levels of some proinflammatory proteins are elevated in AD brain tissue, whether these proteins have negative or positive effects is still u...American Chemical Society's Weekly PressPac -- May 30, 2007
.... In SCD, a mutation in the gene that encodes for beta globin results in abnormal hemoglobin that gives ...rs showed that SB-Tn system could transfer normal beta globin genes into cells. The system, named for a fish gene reawakened by other researchers in 1997 ...UCLA researchers reprogram normal tissue cells into embryonic stem cells
...then be prodded into becoming various cells types beta islet cells to treat diabetes, hematopoetic cells to create a new blood supply for a leukemia patient, motor neuron cells to treat Parkinsons disease. If we can recreate this in human cells, it has significant implications for regenerative therapi...Blocking beta1-integrin to treat cancer
...sgenic mice with insulinomas tumours of pancreatic beta cells, which metastasize in pancreas lymph nodes. When theauthors blocked beta1-integrin function in these mice, tumour cells started disseminating intolymphatic blood vessels because they were not attached to anything any more. However, thecells did...New clues to stroke role in Alzheimer's
...ecursor protein to form a shorter protein called A beta peptide. It is this A beta peptide that is the building block for the amyloid plaques that are a hallmark of AD. The research...Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
... form of amylin, a satiety hormone produced by the beta cells of the pancreas, which also produce insulin. Satiety hormones are commonly thought to control food intake by signaling to the brain when we are full, said Christian Weyer, M.D., the studys senior author and executive director of clinical rese...Paving the way toward a vaccine against Alzheimer's disease
...reatments is to destroy clumps of a protein called beta amyloid, which are found in the brains of people w...en down into pieces, some of which are the amyloid beta proteins. If the antibodies are not present, the proteins start clustering and ultimately kill the c...Cord blood may preserve insulin levels in children with type 1 diabetes
...e 1 diabetes. Together with our work, showing that beta cells producing insulin can be formed using cord blood, we are on track to help diabetes patients in the future. The first step, though, has to be quietening the immune system attack, and this is why the work in Gainesville is so important....Researchers find gene that spurs development of the epididymis
...gene for one component of a growth factor, inhibin beta A, is highly expressed in the part of the Wolffian...ses in response to a rise in testosterone. Inhibin beta A forms part of a protein, activin, that spurs a cascade of activity in certain cells. By staining...M. D. Anderson team identifies new oncogene for brain cancer
...GFBP2 combined with platelet-derived growth factor beta (PDGFB) results in a higher-grade form of the cancer than that caused by PDGFB alone. The high-grade tumors formed by the combination were indistinguishable in their shape and brain-invasive behavior from human oligodendrogliomas. The combination...JCI Table of Contents -- July 2, 2007
...is an autoimmune disease that specifically affects beta cells within the pancreas and researchers have long asked why only certain organs are targeted in autoimmune disease. In so-called NOD mice (an animal model of type 1 diabetes) T and B cells that infiltrate the pancreatic islets have been shown to ...Alzheimer's prevention role discovered for prions
...ormal prion protein on the successful formation of beta amyloid, the source of Alzheimers plaques. They found that beta amyloid did not form in cells with higher than usual levels of PrPc. In comparison, when the level o...Pumpkin: A fairytale end to insulin injections?
...iabetic rats, boosting levels of insulin-producing beta cells and insulin in the blood, reports Lisa Richards in Chemistry & Industry, the magazine of the SCI. A group, led by Tao Xia of the East China Normal University, found that diabetic rats fed the extract had only 5% less plasma insulin and 8% f......s. For example, detection of neutrinoless double beta decay, which can be done at Homestakes SUSEL, is the only way to determine whether neutrinos are their own anti-particle, said Lesko, a veteran neutrino researcher with Berkeley Labs Nuclear Science Division. To fully understand the neutrino, Lesk...JCI table of contents: July 12, 2007
...g of many molecules to platelet integrin alpha-IIb beta 3, and blockade of this binding is effective in th...er, chronic use of oral drugs that block alpha-IIb beta 3 activation have not proved beneficial in preventing recurrent blood clots. In a study appearing on...Gene discovered for type 1 diabetes in children
...which the immune system destroys insulin-producing beta cells in the pancreas and makes patients dependent on frequent insulin injections to keep the bodys blood sugar under control. As the project continues, the study team expects to identify additional genes (perhaps as many as 15 or 20) thought to inte...JCI table of contents: July 19, 2007
...n resistance, diabetes, abnormal insulin-producing beta cells, high cholesterol, and excess fat deposition in the abdomen and liver. The results show that insulin resistance and resultant effects, owing to a specific defect in muscle PKC-lambda, is sufficient to cause abdominal obesity and other abnormali...New clue into how diet and exercise enhance longevity
...receptor substrates, Irs2, in liver and pancreatic beta cells, we thought more Irs2 would be good for you,...th, survival and insulin secretion from pancreatic beta cells. In earlier work, the researchers had found that knocking out both copies of the Irs2 gene ...Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
...attacks and destroys insulin and insulin-producing beta cells in the pancreas. Insulin is a hormone that is needed to convert sugar, starches and other food into energy. Insulin typically is given through shots and not pills so the hormone can go straight into the bloodstream. In Daniells method, plant...