Tag: "beta" at biology news
Finding an Alzheimer's switch
...isease invades the brain is the so-called "amyloid beta
protein cascade," in which a protein called APP is...ely unknown.) If the portion of APP clipped by the beta
form of secretase is further clipped by a third form, gamma secretase, the resulting fragments are a...
The fat connection
... remains in the bloodstream, the insulin-producing beta
cells in the pancreas compensate by stepping up production. Eventually this leads to beta
cell exhaustion, reduced insulin output and the appearance of full-blown diabetes. Elevated fat in t...
National Institute on Aging awards UCI $9 million to continue Alzheimer's disease research
... first that early accumulation of a protein called beta
amyloid within the neurons of transgenic mice is the trigger for the onset of memory decline in Alzheimer's disease. Established in 2000, the ADRC program is committed to pioneering research initiatives that use the latest computer technology to col...
JCI table of contents June 1, 2005
...MENTARY: TITLE: Understanding globin regulation in beta
thalassemia: it's as simple as alpha, beta, gamma, delta AUTHOR CONTACT: Arthur Bank Columbia University, New York, NY USA Phone: 212-305-4186; Fax: 212-923-2090; E-mail: firstname.lastname@example.org View the PDF of this article at: https://www.the-jci.org...
JCI table of contents July 1, 2005
...ww.the-jci.org/article.php?id=24307 ONCOLOGY TGF beta
system sees cancer coming TGF beta1 is a protein ...motion effects. Although it is clear that the TGF beta
type II receptor (TGFbetaRII) is required for TGF beta1-mediated tumor suppression, studies regardin...
Researchers get first peek at amyloid's spine
...r lower-resolution models, such as the two stacked beta
sheets composed of the main chain of amino acids. ...ino acid its unique identity and hold the pairs of beta
sheets in formation. Nelson expected to see only the ends of the side chains reaching out and touch...
Joslin scientists confirm link between PKC enzyme and kidney disease in diabetes
... activation of a specific form of the PKC enzyme - beta
2 - to the abnormal kidney changes and oxidative s...ls - was three times higher in the nondiabetic PKC beta
2 transgenic mice than in normal mice. These findings demonstrate that chronic activation of the PKC...
The making and breaking of microtubules
...t identical tubulin proteins, dubbed the alpha and beta
forms. During polymerization the dimers stack end ...e growth. When GTP binds to a particular locus on beta
tubulin (the E-site or exchangeable site) polymerization occurs: tubulin dimers pile onto the protof...
JCI table of contents July 1, 2005
...University establish the role of LXR alpha and LXR beta
as regulators of renin. The data provide informat...ent of novel selective modulators of LXR alpha and beta
for several disorders including hypertension and heart failure. TITLE: Liver X Receptors alpha and...
Living with salt
...which is commercially grown as a source of natural beta
carotene, has been investigated at the Weizmann Institute for over 30 years. Yet, the secrets of its exceptionally successful adaptation to salt remained unresolved. In a recent paper published in the Proceedings of the National Academy of Sciences, ...
Joslin-chaired study shows new compound may decrease vision loss in diabetes
...pothesize that activation of PKC -- especially the beta
isoform -- is the major signaling pathway stimulated by hyperglycemia (high blood glucose associated with diabetes). In diabetic animal models, the lab also showed that abnormal activation of PKC is an important factor in decreasing blood flow to the...
Pinpointing a culprit molecule in Alzheimer's disease
...hat, when clipped by enzymes, produces the amyloid beta
(Ab) peptide that clusters into the amyloid plaque... The clipping of APP produces two types of amyloid beta
peptide--one 40 amino acid units long (Ab40) and one 42 units long (Ab42). Circumstantial evidence h...
JCI Table of contents August 1, 2005
...ut is good for the gallstones Four years ago, the beta
klotho gene in mice and its human homologue were i...enotypes in mice. However, the precise function of beta
Klotho has been unknown. In a new study appearing on August 1 in The Journal of Clinical Investiga...
Joslin researchers discover new gene for type 2 diabetes using DNA chips
...strate that reducing the level of the ARNT gene in beta
cells in culture also produced defects in glucose-... and impaired functioning of the insulin-producing beta
cells in the pancreas. Both of these have some element of genetic programming. In 2 to 5 percent of...
New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
...by which time destruction of the insulin-producing beta
cells of the pancreas has already progressed signi...ystem mistakenly attacks its own insulin-producing beta
cells and eventually kills them. Early in this process, white blood cells called T lymphocytes infil...
Quicker, cheaper DNA sequencing goal of UH profs with $4.2 million NIH grant
...t. Subsequently, this instrument will be used for beta
testing by various Houston researchers, whose feedback will be incorporated into future phases of technology development. Such strides will eventually increase the scope and scale of research that addresses genomic contributions to such common disea...
One shot: A molecular movie of events that enable sperm to penetrate egg's coating
...late exocytosis--to regulate the insulin-producing beta
cells of the pancreas to prevent diabetes or to get neurotransmitters released in the brain at the right time or concentration," Mayorga pointed out. "Those are all examples of regulated exocytosis, and AE is a simple model they can use."...
Researchers gain support from Merck Sharp & Dohme for novel area of diabetes research
...t up this year to advance current understanding of beta
cell research which is crucial to advancing treatm...portant areas of advancement in diabetes research, beta
cell function, survival and regeneration. The EFSD has entered into many partnerships but this is t...
Researchers discover how compounds prevent viruses from entering cells
...different classes of defensins, theta-defensin and beta
defensin. Membranes--the outer covering of cells and of many kinds of viruses--are coated with a layer of molecules called glycoproteins. The glycoproteins protrude from the membranes' surface, in somewhat the same way bristles stick out of a hair...
Clearing jams in copy machinery
...tigator, now shows that one of these proteins, the beta
sliding clamp, serves as a toolbelt from which the...isms such as humans have more). As the ring-shaped beta
sliding clamp works its way along the DNA double helix, a network of proteins work together to unwin...
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