Tag: "beta" at biology news
Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models
...myloid precursor protein (APP) releasing the toxic beta
amyloid fragments that clump together to form the ...s. One of the enzymes doing the cleaving is called beta
secretase or BACE1. And although the production of beta
amyloid occurs in all brains, healthy brains...
Study points to molecular origin of neurodegenerative disorders, including Huntington's disease
...o take on a specific shape in the protein called a beta
helix. Moreover, the tendency to form a beta
helix increases as glutamine tract length becomes longer. "In our simulations, when the length is 25...
Gene variants linked with increased risk of death among heart patients treated with beta-blockers
...and three-year mortality among patients prescribed beta
blocker therapy," the authors report. "For the 79 CG polymorphism, three-year mortality rates were 16 percent (35 deaths), 11 percent (27 deaths), and six percent (four deaths) for the CC, CG, and GG genotypes, respectively," they write. "For the A...
Study demonstrates how gene variant may contribute to cancer development
...ctober 5 issue of JAMA. Transforming growth factor beta
(TGF-beta) is a potent naturally occurring inhibitor of cell growth, according to background information in the article. It exerts its action by binding to type I (TGFBR1) and type II (TGFBR2) receptors located on the cell membrane. Increased cell gr...
Inherited gene change also found in spontaneous tumors
...ing growth factor beta. Transforming growth factor beta
normally slows the growth of cells known as epithelial cells, and may stimulate the growth of cancerous epithelial cells. (Epithelial cells line the ducts, passages and hollow organs of the body and are the cells in which most cancers arise.) This s...
GSA should stand for 'going strong again' for the UC Department of Geology as always
...ggregate global diversity increase. "This is where beta
diversity comes in," Miller continues. Students De...research. "My students and I have been focusing on beta
diversity, which can be viewed as measuring the amount of difference in the compositions of biotas i...
Low blood glucose levels may complicate gastric bypass surgery, study shows
... leaving them with inappropriately high numbers of beta
cells." Finally, after gastric bypass surgery, GL...ot immediate suggests that active expansion of the beta
cell mass contributed to the condition," Dr. Patti adds. Other researchers participating in the stud...
Molecular drug pump may help reduce risk of Alzheimer's
...), accelerates clearance from the brain of amyloid beta
(A-beta) peptide, the primary component of the plaques that are the hallmark of Alzheimer's disease. According to scientists, the new link is potent and intriguing enough to suggest several potential follow-up studies, including investigations of ho...
Tips from the Journals of the American Society for Microbiology
...ose responsible for the production of the cytokine beta
interferon while infection with HSV-1 did not. "H...sitive human neurons to become strong producers of beta
interferon. Journal of Virology, 79. 20: 12893-12904.)...
Alcoholism research reveals promising new approach to treating Alzheimer's disease
...entists believe that overproduction of the amyloid beta
protein in the brain causes Alzheimer's disease. P...he blood brain barrier and lower levels of amyloid beta
protein in mice. Banks tested whether the antisense theory could be generalized to reduce other brai...
Early cardiac screening necessary for muscular dystrophy patients
...15 years, 31 boys were started on ACE inhibitor or beta
blocker therapy. During the follow-up two patients remained stable with their dilated cardiomyopathy, eight showed improvement and 19 normalized both heart size and function. "This study also helped us realize that while some dystrophin-gene mutation...
SWI/SNF and erythropoiesis
...d may provide insight into common ailments such as beta
thalassemia and anemia."...
Two genetic traits giving Africans malaria protection lose effectiveness when they occur together
...-which is common in sub-Saharan Africa but, unlike beta
thalassemia, is not associated with major health problems--also helps people fight malaria. While not offering as much protection as the sickle trait, Williams said children with the thalassemia trait are less likely to die from a malaria infection ...
Scientists engineer mice to mimic Alzheimer's therapy
...emical reactions - create peptide fragments called beta
amyloid, also known as Abeta. The fragments clump together to form senile plaques, clogging the spaces between cells and damaging parts of the brain used for memory and decision-making. The mice were genetically engineered by scientists to respond to...
New cell transplantation technique restores insulin production in diabetics
...ts from the destruction of insulin-producing islet beta
cells in the pancreas. Insulin is necessary to metabolize sugar, which is the basic fuel that all cells need. With this minimally invasive technique, donor islet cells are injected into diabetic patients so that the new, healthy islet cells can resto...
Genetic key to growth of new arteries is identified
...ors of the study. The mice carried a marker gene, beta
galactosidase, that turns tissues blue. Different strains of the mice had different fragments of the MMP2 gene coupled to the so-called blue gene. Leg muscles turned blue only in the strain of mice with the specific gene fragment that turns on in res...
Gladstone researchers identify new drug target for Alzheimer's disease
... cultures, the scientists investigated how amyloid beta
proteins, which build up in the brain tissue of pe...boratory rats. Study findings showed that amyloid beta
could be prevented from causing neuronal cell death with a compound called resveratrol, which is als...
Bone quality regulator identified, suggests drug target
...e team explored whether transforming growth factor beta
(TGF-) regulates the properties of bone matrix because there were hints that it might. TGF- is known to play a role in the development of osteoblasts, cells that produce bone matrix. The researchers carried out their evaluation in five sets of mice ...
Roche and SystemsX collaborate in diabetes research
...t research project entitled Systems biology of the beta
cell-application to type 2 diabetes progression. T...velopment in diabetes as well as new biomarkers of beta
cell failure for diagnostics. Beta cells which are located in the isles of Langerhans in the pancrea...
Infectious agent thwarts typical defense mechanisms; Sheds light on immune system function
...rease of a chemical messenger called interleukin-1 beta
(IL-1B). IL-1B tells the rest of the immune system and the body that an invader is present, and increased levels of IL-1B trigger a fever one of the mechanisms the body uses to rid itself of some pathogens. IL-1B levels typically increase as the imm...
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